Patents by Inventor Vitaly J. Vodyanoy
Vitaly J. Vodyanoy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9132086Abstract: A composition, system and method for modifying an olfactory response to an odorant is disclosed. In some embodiments, the composition includes crystalline metal nanoparticles dispersed in an aqueous medium. The composition is applied to olfactory tissues using a suitable applicator or dispenser. The metal nanoparticles are believed to interact with a G-protein coupled to receptor located in the cilia to moderate (enhance or reduce) sensitivity or ability to smell particular odorants. In accordance with an embodiment of the invention, the composition includes one or more odorants.Type: GrantFiled: September 17, 2013Date of Patent: September 15, 2015Assignee: AUBURN UNIVERSITYInventors: Vitaly J. Vodyanoy, Nilmini Viswaprakash, Ludmila Petrovna Globa, Edward E. Morrison
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Patent number: 8778409Abstract: A composition, system and method for modifying an olfactory response to an odorant is disclosed. In some embodiments, the composition includes crystalline metal nanoparticles dispersed in an aqueous medium. The composition is applied to olfactory tissues using a suitable applicator or dispenser. The metal nanoparticles are believed to interact with a G-protein coupled to receptor located in the cilia to moderate (enhance or reduce) sensitivity or ability to smell particular odorants. In accordance with an embodiment of the invention, the composition includes one or more odorants.Type: GrantFiled: September 21, 2012Date of Patent: July 15, 2014Assignee: Auburn UniversityInventors: Vitaly J. Vodyanoy, Lewis G. Scharpf, Alexandre Samoylov, Nilmini Viswaprakash, Ludmila Petrovna Globa, Edward E. Morrison
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Publication number: 20140017338Abstract: A composition, system and method for modifying an olfactory response to an odorant is disclosed. In some embodiments, the composition includes crystalline metal nanoparticles dispersed in an aqueous medium. The composition is applied to olfactory tissues using a suitable applicator or dispenser. The metal nanoparticles are believed to interact with a G-protein coupled to receptor located in the cilia to moderate (enhance or reduce) sensitivity or ability to smell particular odorants. In accordance with an embodiment of the invention, the composition includes one or more odorants.Type: ApplicationFiled: September 17, 2013Publication date: January 16, 2014Applicant: Auburn UniversityInventors: Vitaly J. Vodyanoy, Nilmini Viswaprakash, Ludmila Petrovna Globa, Edward E. Morrison
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Patent number: 8298793Abstract: Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are misfolded or partially misfolded proteins surrounding a metallic nanocluster, termed “proteon nucleation center” (PNC). Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form.Type: GrantFiled: September 19, 2006Date of Patent: October 30, 2012Assignee: Auburn UniversityInventors: Vitaly J. Vodyanoy, Alexandre M. Saamoylov, Oleg M. Pustovyy
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Patent number: 8273381Abstract: A composition, system and method for modifying an olfactory response to an odorant is disclosed. In some embodiments, the composition includes crystalline metal nanoparticles dispersed in an aqueous medium. The composition is applied to olfactory tissues using a suitable applicator or dispenser. The metal nanoparticles are believed to interact with a G-protein coupled to receptor located in the cilia to moderate (enhance or reduce) sensitivity or ability to smell particular odorants. In accordance with an embodiment of the invention, the composition includes one or more odorants.Type: GrantFiled: March 27, 2008Date of Patent: September 25, 2012Assignee: Auburn UniversityInventors: Vitaly J. Vodyanoy, Lewis G. Scharpf, Jr., Alexandre Samoylov, Nilmini Viswaprakash, Ludmila Petrovna Globa, Edward E. Morrison
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Publication number: 20110284087Abstract: A system and method for passive collection of oil from water based on a density differential. A sealed column of water is elevated above the oil/water surface within a low pressure contained volume, and oil moves upward into the contained volume displacing the water due to the lower density of the oil. Filled containers of oil are exchanged for containers of water, or oil is transferred from the filled containers.Type: ApplicationFiled: May 18, 2011Publication date: November 24, 2011Applicant: AUBURN UNIVERSITYInventors: Vitaly J. VODYANOY, Timothy E. MOORE, Kenny V. BROCK, Oleg M. PUSTOVYY
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Patent number: 7872108Abstract: Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.Type: GrantFiled: April 22, 2008Date of Patent: January 18, 2011Assignee: Auburn UniversityInventors: Vitaly J. Vodyanoy, Alexandre M. Samoylov, Oleg M. Pustovyy
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Patent number: 7871772Abstract: Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.Type: GrantFiled: November 16, 2006Date of Patent: January 18, 2011Assignee: Auburn UniversityInventors: Vitaly J. Vodyanoy, Alexandre M. Samoylov, Oleg M. Pustovyy
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Patent number: 7759134Abstract: A magnetostrictive ligand sensor device (MLSD), system and method are provided having at least one magnetostrictive particle (MSP) to which is bound at least one binding element. The MSP may be dispersed in a sample containing a target ligand such that the target ligand binds thereto. A driver is also provided to emit a varying magnetic field such that the MSP produces a resonance response detectable by a measurement device configured to receive and detect changes in the resonance response that are due to alterations of the binding element. The MLSD and assays find use in identifying and quantitating ligands as well as chemicals and environmental conditions in a sample or patient.Type: GrantFiled: August 20, 2004Date of Patent: July 20, 2010Assignee: Auburn UniversityInventors: Bryan A. Chin, Zhongyang Cheng, Vitaly J. Vodyanoy, James Barbaree, Valery A. Petrenko, Tung-Shi Huang, Howard C. Wikle, III
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Patent number: 7670765Abstract: Methods and compositions for identifying and characterizing the affinity of one or more ligands of a peptide are provided. In particular, a “stripped phage ligand sensor device” (SPLSD) is provided comprising a sensor coupled to a binding element of interest. Binding elements of the invention comprise phage which in most embodiments express a peptide of interest on the phage surface. Assays using the SPLSD allow detection and quantitation of ligands. Also provided are improved methods for forming monolayers using phage. In particular, methods for the formation of monolayers using “stripped phage” are provided. Further provided are monolayers and Langmuir-Blodgett films formed by the methods of the invention as well as substrates having deposited thereon the films of the invention. The monolayers, films and substrates of the invention are useful as components of biosensors and/or chemosensors.Type: GrantFiled: November 27, 2006Date of Patent: March 2, 2010Assignee: Auburn UniversityInventors: Valery A. Petrenko, Vitaly J. Vodyanoy, Jennifer Cannon Sykora
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Patent number: 7604807Abstract: Compositions and methods for the reversible preservation of biological samples are provided. The compositions include natural polymers such as pullulan or acacia gum, including derivations and modifications thereof, which are usefull as a reversible preservation solution. A method is provided for using pullulan or Acacia Gum to isolate and reversibly preserve a biological specimen in a dormant state at room temperature for an extended period with minimal damage to the specimen. The compositions and methods disclosed may also be used to create reversibly preserved biological specimens and biological receptors for use in biosensors.Type: GrantFiled: January 27, 2006Date of Patent: October 20, 2009Assignee: Auburn UniversityInventors: Vitaly J. Vodyanoy, James M. Barbaree, Bryan A. Chin, William Charles Neely, Suram T. Pathirana, Timothy D. Braden
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Patent number: 7564623Abstract: An illumination system for a microscope, including a light source for generating light to illuminate a sample for microscopic observation, at least one collimating lens for collimating light generated by the light source, and a darkfield condenser for receiving collimated light and directing a hollow cone of light onto the sample under observation. The system optionally includes an adapter for enhancing economy of light transmission from the light source to the specimen, the adapter having a centrally disposed spacer and a plurality of optical fibers surrounding the spacer, to generate a hollow cylinder of light for transmission to the darkfield condenser. The system provides improved resolution and contrast, and is well suited for adaptation to fluorescence microscopy techniques.Type: GrantFiled: April 15, 2005Date of Patent: July 21, 2009Assignee: Auburn UniversityInventors: Vitaly J. Vodyanoy, Oleg M. Pustovyy
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Patent number: 7542203Abstract: The present invention is a dark field illumination system including a light source which is fixed on an entrance slit of a condenser and an objective aligned with the condenser such that the objective and the condenser are adjusted to find a focus spot on a sample. The present invention essentially uses structured illumination to achieve an improved illumination system. The present invention also includes a system and method wherein the objective is coupled to an iris and aligned with the condenser such that when the iris is closed only dark field images are produced, and when the iris is open, direct entrance of light is allowed into the objective and bright field illumination is produced.Type: GrantFiled: July 14, 2006Date of Patent: June 2, 2009Assignee: Auburn UniversityInventors: Vitaly J. Vodyanoy, Oleg M. Pustovyy, Arnold Vainrub
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Patent number: 7473550Abstract: Compositions and methods for the reversible preservation of biological samples are provided. The compositions include Acacia Gum, including derivations and modifications thereof which are useful as a reversible preservation solution. A method is provided for using Acacia Gum to isolate and reversibly preserve a biological specimen in a dormant state at room temperature for an extended period with minimal damage to the specimen. The compositions and methods disclosed may also be used to create reversibly preserved biological specimens and biological receptors for use in biosensors.Type: GrantFiled: March 7, 2005Date of Patent: January 6, 2009Assignee: Auburn UniversityInventors: Vitaly J. Vodyanoy, James M. Barbaree, Bryan A. Chin, William Charles Neely, Suram T. Pathirana, Timothy D. Braden
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Publication number: 20080262206Abstract: Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.Type: ApplicationFiled: April 22, 2008Publication date: October 23, 2008Applicant: Auburn UniversityInventors: Vitaly J. Vodyanoy, Alexandre M. Samoylov, Oleg M. Pustovyy
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Patent number: 7267993Abstract: Methods and compositions for identifying and characterizing one or more ligands of a peptide are provided. In particular, the invention provides a phage ligand sensor device (PLSD) comprising a sensor coupled to a binding element of interest. Binding elements of interest comprise phage displaying at least one foreign peptide. The PLSD and assays find particular use in identifying and characterizing ligand-peptide interactions.Type: GrantFiled: November 7, 2002Date of Patent: September 11, 2007Assignee: Auburn UniversityInventors: Valery A. Pentrenko, Vitaly J. Vodyanoy, Alexandre M. Samoylov, Iryna Sorokulova, Viswaprakash Nanduri, Bryan A. Chin, James M. Barbaree, W. Charles Neely
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Patent number: 7138255Abstract: Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.Type: GrantFiled: September 30, 2003Date of Patent: November 21, 2006Assignee: Auburn UniversityInventors: Vitaly J. Vodyanoy, Alexandre M. Samoylov, Oleg M. Pustovyy
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Patent number: 7106503Abstract: A direct-view optical microscope system is provided which uses high-energy light from a phenomenon known as non-resonant Raman scattering to illuminate a living biological specimen. One embodiment of the system combines two discrete light sources to form a combined incident light source for the microscope. The system includes a method and apparatus for modulating the intensity of the scattered light when two light waves are combined to produce the incident light. By varying the frequency of the two source light waves, the intensity of the combined Raman-scattered light can be modulated to achieve finer resolution.Type: GrantFiled: February 28, 2005Date of Patent: September 12, 2006Assignee: Auburn UniversityInventors: Vitaly J. Vodyanoy, William Charles Neeley
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Patent number: 7022514Abstract: Compositions and methods for the reversible preservation of biological samples are provided. The compositions include Acacia Gum, including derivations and modifications thereof which are useful as a reversible preservation solution. A method is provided for using Acacia Gum to isolate and reversibly preserve a biological specimen in a dormant state at room temperature for an extended period with minimal damage to the specimen. The compositions and methods disclosed may also be used to create reversibly preserved biological specimens and biological receptors for use in biosensors.Type: GrantFiled: November 30, 2001Date of Patent: April 4, 2006Assignee: Auburn UniversityInventors: Vitaly J. Vodyanoy, James M. Barbaree, Bryan A. Chin, William Charles Neely, Suram T. Pathirana, Timothy D. Braden
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Patent number: 6992819Abstract: A direct-view optical microscope system is provided which uses high-energy light from a phenomenon known as non-resonant Raman-scattering to illuminate a biological specimen. One embodiment of the system combines two discrete light sources to form a combined incident light source for the microscope. The system includes a method and apparatus for modulating the intensity of the scattered light when two light waves are combined to produce the incident light. By varying the frequency of the two source light waves, the intensity of the combined Raman-scattered light can be modulated to achieve finer resolution. In one embodiment, the system provides illumination and observation of microscopic agglutination events between pathogenic antigens and specific antibodies, for prompt detection and identification in the field.Type: GrantFiled: June 13, 2003Date of Patent: January 31, 2006Assignee: Auburn UniversityInventor: Vitaly J. Vodyanoy