Patents by Inventor Vito Graziano

Vito Graziano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10065989
    Abstract: The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: September 4, 2018
    Assignees: The Broad Institute Inc., President and Fellows of Harvard College, Rijksuniversiteit Groningen
    Inventors: Walter F. Mangel, Paul Blainey, Vito Graziano, Andreas Herrmann, William J. McGrath, Antonius Martinus Van Oijen, Xiaoliang Sunney Xie
  • Publication number: 20170062407
    Abstract: A power transistor device such as, e.g., a power MOS device includes a control line for controlling a device current flowing through the device. The device includes a plurality of cells contributing respective fractions of the device current with a plurality of control terminals each adapted to control current flow through one of the cells. The device includes respective decoupling resistors between the control line and the control terminals. Upon failure of one of the cells, the other non-failed cells can be rendered nonconductive by a switch-off control signal applied via the control line.
    Type: Application
    Filed: March 31, 2016
    Publication date: March 2, 2017
    Inventors: Rosario Ruggeri, Vito Graziano
  • Publication number: 20150210738
    Abstract: The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.
    Type: Application
    Filed: January 13, 2015
    Publication date: July 30, 2015
    Inventors: Walter F. MANGEL, Paul BLAINEY, Vito GRAZIANO, Andreas HERRMANN, William J. MCGRATH, Antonius Martinus VAN OIJEN, Xiaoliang Sunney XIE
  • Patent number: 6084286
    Abstract: An integrated device comprises a high-voltage transistor and a low-voltage transistor in an emitter-switching configuration integrated in a chip (400) of semiconductor material comprising a buried P-type region (120) and a corresponding P-type contact region (405) which delimit a portion of semiconductor material within which the low-voltage transistor is formed. The contact region (405) has a network structure such as to divide this portion of semiconductor material into a plurality of cells (410) within each of which there is an elemental P-type base region (425) and an elemental N-type emitter region (430) of the low-voltage transistor. The elemental regions (425) and (430) of the various cells (410) are electrically connected to one another by means of surface metal contacts.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: July 4, 2000
    Assignee: SGS-Thomsom Microelectronics, S.r.l.
    Inventors: Natale Aiello, Vito Graziano, Atanasio La Barbera, Stefano Sueri
  • Patent number: 5986411
    Abstract: The present invention relates to an integrated circuit adapted to perform the function of a diode of the DIAC type, the circuit having an input terminal and an output terminal. The circuit includes a first input transistor having a first terminal connected to a fixed voltage reference, a second terminal, and a control terminal coupled to the input terminal of the circuit. The circuit further includes second and third transistors in a current mirror configuration, each having a first terminal for coupling to the input terminal of the circuit, and a second terminal, and associated control terminals connected together and coupled to the second terminal of the first input transistor, the second terminal of the second transistor being connected to the control terminal of the first transistor.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: November 16, 1999
    Assignee: SGS-Thomson Microelectronics S.r.l.
    Inventors: Stefano Sueri, Atanasio La Barbera, Natale Aiello, Vito Graziano
  • Patent number: 5828244
    Abstract: A driver circuit delays the turning on of a MOS transistor by utilizing the time-wise pattern of the circuit input signal rather than generating a delay within the circuit itself. A threshold type of circuit element is arranged so that no current flows toward or from, depending on the type of the MOS transistor, the control terminal before the voltage at the circuit input exceeds a predetermined value. This is achieved, for example, by coupling a Zener diode serially to the control terminal. Where the input signal is of a kind which increases with a degree of uniformity, the time required to exceed that threshold will correspond to the desired delay. Thus, the driver circuit can match the dynamic range of the input signal automatically.
    Type: Grant
    Filed: July 30, 1996
    Date of Patent: October 27, 1998
    Assignees: SGS-Thompson Microelectronics S.r.l., Consorzio per la Ricerca sulla Microelettronica nel Mezzogiorno
    Inventors: Sergio Palara, Vito Graziano
  • Patent number: 5804866
    Abstract: A method and device for maintaining junction isolation between a second region that is normally clamped at a reference potential, contained within a first region of an opposite type of conductivity whose potential is subject to large inertial swings. The junction is ensured even when the potential of the first region moves toward and beyond the reference potential to which the second region is clamped, by connecting the second region to the reference potential by a switch, and causing the switch to open which places the second region in a floating state, leaving it free to track the potential excursion of the first region. The switch is closed after the potential of the first region has returned to a normal value. A comparator senses a shift of the potential of the second region from the reference potential to which it is clamped. The shift is dynamically induced by the capacitive coupling of the two regions, and triggers off the clamping switch.
    Type: Grant
    Filed: March 21, 1996
    Date of Patent: September 8, 1998
    Assignee: Consorzio per la Ricerca sulla Microelettronica nel Mezzogiorno
    Inventors: Natale Aiello, Vito Graziano
  • Patent number: 5763934
    Abstract: The present invention relates to an electronic device integrated monolithlly on a semiconductor material comprising a substrate having a first conductivity type in which are formed first and second diffusion regions of a second conductivity type. The substrate and the first and second diffusion regions defining a base region, a collector region and an emitter region of a parasitic transistor. The second diffusion region includes a third diffusion region having conductivity of the first type to provide in the second diffusion region a resistive path placed in series with the emitter region of the parasitic transistor while backfeeding it negatively and taking it to saturation with a resulting reduction of its current gain and limitation of the maximum current due thereto.
    Type: Grant
    Filed: December 24, 1996
    Date of Patent: June 9, 1998
    Assignee: Co.Ri.M.Me-Consorzio per la Ricerca sulla Microelectronica nel
    Inventors: Natale Aiello, Vito Graziano
  • Patent number: 5712776
    Abstract: A start up circuit causes a MOS transistor to be turned on by sensing local electrical quantities thereof, specifically the potential at the drain terminal of the MOS transistor. A small current is injected into the control terminal of the MOS transistor when the potential at the drain terminal is high. For the purpose, an electric network is arranged to couple these two terminals together.
    Type: Grant
    Filed: July 30, 1996
    Date of Patent: January 27, 1998
    Assignees: SGS-Thomson Microelectronics S.r.l., Consorzio per la Ricerca sulla Microelettronica nel Mezzogiorno
    Inventors: Sergio Palara, Vito Graziano