Abstract: The invention describes new chiral stationary phases containing a 4-amino-3,5-dinitrobenzoic unit modified with chiral groups and spacer groups. The invention includes the process for the preparation of said stationary phases starting from 4-halogenated derivative of 3,5-dinitrobenzoic acid, chiral selectors obtainable as intermediates in the aforesaid process, and the use of the chiral stationary phases in the separation of enantiomers.

Abstract: The invention describes new hyaluronan derivatives where the hydroxyl groups are esterified or carbamoylated in amounts ranging from 0.01% to 100% and the carboxyl groups are either totally or partially esterified with alcohols or are in the form of salt.

Abstract: The invention describes new chiral stationary phases containing a 4-amino-3,5-dinitrobenzoic unit modified with chiral groups and spacer groups. The invention includes the process for the perparation of said stationary phases starting from 4-halogenated derivative of 3,5-dinitrobenzoic acid, chiral selectors obtainable as intermediates in the aforesaid process, and the use of the chiral stationary phases in the separation of enantiomers.

Abstract: The present invention describes new chiral stationary phases and optically active compounds therein contained. The optically active compounds contained in the stationary phases are represented by the formula of structure (I), containing at least one asymmetric carbon atom, and a substituent acting as a spacer. The stationary phases of the present invention are useful in the preparation of chromatographic columns useful for the separation of enantiomers.

Abstract: A method for manufacturing S-3-(4'-tert-butyl)-phenyl-2-methyl propylamines having the structure I ##STR1## where NR.sub.1 R.sub.

Abstract: A method for preparing N(1)-alkylated-5-phenyl-7-substituted deoxy-1,4-benzodiazepines utilizing a polyphosphoric acid alkyl ester of the formula: ##STR1## wherein R.sub.3 is an alkyl radical with up to 4 carbon atoms as the alkylating agent, is described.

Abstract: A process for preparing 5-nitroimidazole compounds of ##STR1## where R and R.sub.1 are each alkyl from 1 to 4 carbon atoms, A is oxygen and n is 1, allowing for improved yields of the final products, is described.

Abstract: Optically active intermediates of the formula: ##STR1## in the S optical configuration wherein R.sub.1 is selected from the group consisting of hydrogen, halogen, nitro and trifluoromethyl, R.sub.2 is selected from the group consisting of hydrogen and C.sub.1-4 lower alkyl, and R.sub.3 is selected from the group consisting of C.sub.1-4 lower alkyl, hydroxy C.sub.1-4 lower alkyl, phenyl, hydroxyphenyl, benzyl, hydroxybenzyl, or 3'-methyleneindolyl, and A is a protective group, and their preparation is described. These compounds are useful in the preparation of corresponding optically active 1,4-benzodiazepines.

Abstract: Compositions, useful as tranquilizers containing, as active ingredient, an optically active compound having the formula: ##STR1## having an asymmetric carbon atom in position 3 having the S configuration and wherein R.sub.1 is selected from the group consisting of hydrogen, halogen, nitro, and trifluoromethyl groups, R.sub.2 is selected from the group consisting of hydrogen and C.sub.1-4 lower alkyl groups and R.sub.3 is selected from the group consisting of C.sub.1-4 lower alkyl, hydroxy C.sub.1-4 lower alkyl, phenyl, hydroxyphenyl, benzyl, hydroxybenzyl, and 3'-methyleneindolyl groups, is described.They are obtained by reaction of a compound having the formula ##STR2## with a compound of the formula wherein A is a protective group.The compounds of formula I have sedative and tranquilizing properties.

Abstract: A process is disclosed for preparing optically active 1,4-diazepine-2-ones by reacting an acid chloride-hydrochloride of an optically active .alpha.-amino acid with a substituted o-amino benzophenone, to form an intermediate product and subsequently cyclizing the intermediate product to form the desired 1,4-diazepine-2-one. The process is carried out in inert organic or aqueous-organic solvents. The process eliminates the need for using .alpha.-amino acids having bound to the amino group a protective group which must be removed before cyclization.

Abstract: Optically active compounds having the formula ##STR1## having an asymmetric carbon atom in position 3 having the S configuration and wherein R.sub.1 is selected from the class consisting of hydrogen, halogen, nitro, and trifluoromethyl groups, R.sub.2 is selected from the group consisting of hydrogen and C.sub.1-4 lower alkyl groups and R.sub.3 is selected from the group consisting of C.sub.1-4 lower alkyl, hydroxy C.sub.1-4 lower alkyl, phenyl, hydroxy phenyl, benzyl, hydroxy benzyl, and 3'-methyleneindolyl groups.They are obtained by reaction of a compound having the formula ##STR2## with a compound of the formula wherein A is a protective group.The compounds of formula I have sedative and tranquilizing properties.

Abstract: A process for the production of piperazine derivatives including the formation of compounds having the general formula ##STR1## wherein Y is a halogen atom, SO.sub.3 H.sup.-, SO.sub.4.sup.-.sup.- or another anion. The compounds exhibit cytostatic, cancer retardant and tranquilizing properties.