Abstract: The present disclosure provides devices, systems, and methods for optimizing blood glucose level regulation by predicting blood glucose levels based on personalized blood glucose regulation models. In some exemplary embodiments, a computer-implemented method of blood glucose level regulation includes collecting a first plurality of data sets associated with an individual from a database, generating a personalized blood glucose regulation model for the individual, receiving a second plurality of data sets associated with the individual, and generating predicted blood glucose levels for the individual using the personalized blood glucose regulation model and the second plurality of data sets.