Patent number: 4387096
Abstract: New derivatives of 1,3-thiazolidin-4-yl carboxylic acid of the general formula I ##STR1## wherein: R represents hydrogen, (C.sub.1-4)alkyl,aralkyl, phenyl, phenyl substituted by a halogen atom or a methoxy group, formyl, acyl, trimethylsilyl;R' represents hydrogen, a pharmaceutically acceptable inorganic or organic cation, (C.sub.1-4)alkyl, 2,2,2-trichloroethyl, acetonly, benzyl, benzyl substituted by nitro or methoxy, phenyl, nitrophenyl, benzhydryl or trimethylsilyl;R' may also represent a radical capable of providing metabolic activation in vivo selected from acetoxymethyl, pivaloyloxymethyl, phthalidyl, benzoyloxymethyl, 5-indanyl, a group of formula ##STR2## or a group of formula ##STR3## in which R" stands for (C.sub.1-4)alkyl, (C.sub.5-6)cycloalkyl or aryl; A represents hydrogen, halogen, N.sub.3, OH, NH.sub.2 ; or a quaternary N-atom, particularly ##STR4## in this case R' is a negative charge); or a O--CO--NH.sub.2 group; or a group of the formula OR"', O--COR"', NH--CO--R"' or SR"', where R"' is (C.
Type:
Grant
Filed:
July 1, 1981
Date of Patent:
June 7, 1983
Assignee:
Ausonia Farmaceutici s.r.l.
Inventors:
Michele di Schiena, Vittoria Orru