Patents by Inventor Vittorio Farina

Vittorio Farina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dideoxyinosine by enzymatic deamination of dideoxyadenosine
    Patent number: 5011774
    Abstract: A novel process utilizing adenosine deaminase to selectively produce .beta.-(D)-2',3'-dideoxyinosine in high yields from an .alpha.,.beta.-anomeric mixture. .beta.-(D)-2',3'-Dideoxyinosine so produced is useful as an antiviral and antibiotic agent.
    Type: Grant
    Filed: February 28, 1990
    Date of Patent: April 30, 1991
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Vittorio Farina, Daniel A. Benigni, Paul R. Brodfuehrer
  • 3-Unsaturated alkyl cephems from 3-triflyl cephems
    Patent number: 4870168
    Abstract: There is disclosed a process for the production of certain 3-hydrocarbyl-3-cephem derivatives wherein the hydrocarbyl group is selected from 1-alkenyl and conjugated and unconjugated 1-polyalkenyl, 1-alkynl, carbocyclic and heterocyclic aryl, and carbocyclic and heterocyclic arylmethyl and, in the case of the 1-alkenyl and conjugated 1-polyalkenyl derivatives, with substantially complete stereospecificity, by coupling a 3-triflyloxy cephem with a hydrocarbyltributylstannane in the presence of bis(dibenzylideneacetonyl)-palladium, a phosphine, and a metal halide such as, for example, zinc chloride. The 3-unsaturated alkyl-3-cephem derivatives so-produced are useful as broad-spectrum antibacterial agents.
    Type: Grant
    Filed: February 26, 1987
    Date of Patent: September 26, 1989
    Assignee: Bristol-Myers Company
    Inventors: Stephen R. Baker, Vittorio Farina, Chester Sapino, Jr.
  • Production of 3-allyl- and 3-butenyl-3-cephems
    Patent number: 4847373
    Abstract: There is disclosed a process for the production of certain 2-allyl- and 3-butenyl-3-cephem derivatives by coupling a 3-chloromethyl-3-cephem with a hydrocarbyltributystannane in the presence of bis(dibenzylideneacetonyl)-palladium and a phosphine. The 3-allyl- and 3-butenyl-3-cephem derivatives so-produced are useful as broad-spectrum antibacterial agents.
    Type: Grant
    Filed: February 26, 1987
    Date of Patent: July 11, 1989
    Assignee: Bristol-Myers Company
    Inventors: Stephen R. Baker, Vittorio Farina, Chester Sapino, Jr.