Patents by Inventor Vittorio SEBASTIANO

Vittorio SEBASTIANO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENERATION OF PRIMORDIAL GERM CELLS AND METHODS OF USING THE SAME
    Publication number: 20230242871
    Abstract: Provided herein are, inter alia, compositions and methods for generating a population of PGCs with improved efficiencies and line-to-line consistency. Inductive signals are temporally dynamic: WNT activation for 12 hours incipiently differentiates primed hPSCs into posterior epiblast, while subsequently, sharp WNT inhibition together with BMP activation specifies PGCs. hPSC-derived PGCs can be easily purified by virtue of their CXCR4+PDGFR?-GARP-surface-marker profile.
    Type: Application
    Filed: May 28, 2021
    Publication date: August 3, 2023
    Inventors: Vittorio Sebastiano, Kyle M. Loh, Gugene Kang
  • TRANSIENT CELLULAR REPROGRAMMING FOR REVERSAL OF CELL AGING
    Publication number: 20210010034
    Abstract: Provided herein are methods and compositions useful in cellular rejuvenation, tissue engineering, and regenerative medicine. Compositions and methods for rejuvenating aged cells and tissues to restore functionality are disclosed. In particular, cells are rejuvenated by transient exposure to non-integrated mRNAs encoding reprogramming factors to rejuvenate cells while retaining cells in a differentiated state.
    Type: Application
    Filed: March 13, 2019
    Publication date: January 14, 2021
    Inventors: Vittorio SEBASTIANO, Tapash J. SARKAR