Patents by Inventor Vivek Halan

Vivek Halan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240010733
    Abstract: The present disclosure relates to novel anti-CLEC2D antibodies and related compositions and methods of use thereof. These antibodies are used as therapeutics, and in prognostic and diagnostic applications in various cancers and other diseases.
    Type: Application
    Filed: May 8, 2023
    Publication date: January 11, 2024
    Inventors: Kavitha Iyer RODRIGUES, Maloy GHOSH, Sunit MAITY, Yogendra Manjunath Bangalore MUNIRAJU, Sathyabalan MURUGESAN, Sanghamitra BHATTACHARJEE, Vivek HALAN, Subhra Parakash CHAKRABARTY, Ashvini Kumar DUBEY, Anurag TIWARI, Kirthana Mysore Vasudevarao SINDHE, Pallavi LAHIRI, Sahana Bhima RAO, Prachi, Shruti SRIVASTAVA, Rao Shreesha RAMESH, Bharath Ravindra SHENOY, Nikitha MARKANDA, Bhagyashree DIKEY, Bairavabalakumar NATARJAN
  • Patent number: 11827710
    Abstract: The present disclosure relates to novel anti-CLEC2D antibodies and related compositions and methods of use thereof. These antibodies are used as therapeutics, and in prognostic and diagnostic applications in various cancers and other diseases.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: November 28, 2023
    Assignee: Zumutor Biologics Inc.
    Inventors: Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Yogendra Manjunath Bangalore Muniraju, Sathyabalan Murugesan, Sanghamitra Bhattacharjee, Vivek Halan, Subhra Prakash Chakrabarty, Ashvini Kumar Dubey, Anurag Tiwari, Kirthana Mysore Vasudevarao Sindhe, Pallavi Lahiri, Sahana Bhima Rao, Prachi, Shruti Srivastava, Rao Shreesha Ramesh, Bharath Ravindra Shenoy, Nikitha Markanda, Bhagyashree Dikey, Bairavabalakumar Natarajan
  • Patent number: 11549119
    Abstract: The present disclosure relates to vectors for cloning and expressing genetic material including but not limiting to antibody gene or parts thereof and methods of generating said vectors. Said vectors express the antibody genes in different formats such as Fab or scFv as a part of intertransfer system, intratransfer system or direct cloning and expression in individual display systems. In particular, phage display technology is used to clone and screen potential antibody genes in phagemid which is followed by the transfer of said genes to yeast vector for further screening and identification of lead molecules against antigens. The present vectors have numerous advantages including uniquely designed inserts/expression cassettes resulting in efficient and smooth transfer of clonal population from phage to yeast vectors resulting in efficient library preparation and identification of lead molecules.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: January 10, 2023
    Assignee: ZUMUTOR BIOLOGICS, INC.
    Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Divya Unnikrishnan, Yogendra Manjunath Bangalore Muniraju, Sathyabalan Murugesan, Pavithra Mukunda, Bhargav Prasad, Veeresha Kamanagowda, Sanghamitra Bhattacharjee, Pravin Kumar Dakshinamurthy, Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar Natarajan, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath Ravindra Shenoy, Sahana Bhima Rao, Subhra Prakash Chakrabarty, Ashvini Kumar Dubey, Amir Khan, Ankurina Sharma, Rashmi Sharma, Anurag Tiwari, Santosh Kumar, Shivani Patel, Nikitha M
  • Patent number: 11548937
    Abstract: The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and non-fucosylated protein products, specifically antibodies from the cell. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. The method of the present disclosure targets the Fut8 gene and GMD gene in a cell. Such products are used in developing therapeutics and biomarkers, and in diagnosis and prognosis of diseases.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: January 10, 2023
    Assignee: Zumutor Biologics Inc.
    Inventors: Bhargav Prasad, Divya Unnikrishnan, Jahnabi Hazarika, Kavitha Iyer Rodrigues, Maloy Ghosh, Pavithra M, Pravin Kumar D, Sanghamitra Bhattacharjee, Sathyabalan M, Sankaranarayanan Srinivasan, Sohang Chatterjee, Sunit Maity, Veeresha K, Vivek Halan, Yogendra Manjunath B. M., Anuradha Hora, Bairavabalakumar N, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath R Shenoy, Rajeshwari Pendse, Prabhat Kumar Pathak, Anisha Kurup, Sahana Bhima Rao
  • Patent number: 11384354
    Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a human naïve antibody gene expression library encompassing a pool of nucleic acid sequences derived from a natural antibody repertoire comprising humoral immunity from healthy and genetically diverse human populations. More specifically, the method employs a combination of phage and/or yeast antibody surface display concept which allows to screen large antibody library size and facilitates better folding of antibody structure. The present disclosure also relates to a human naïve antibody library generated by employing the process of the present disclosure, a set of primers employed in the method and application(s) of said antibody library.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: July 12, 2022
    Assignee: ZUMUTOR BIOLOGICS INC.
    Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Divya Unnikrishnan, Yogendra Manjunath Bangalore Muniraju, Sathyabalan Murugesan, Pavithra Mukunda, Bhargav Prasad, Veeresha Kamanagowda, Sanghamitra Bhattacharjee, Pravin Kumar Dakshinamurthy, Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar Natarajan, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath Ravindra Shenoy, Sahana Bhima Rao, Subhra Prakash Chakrabarty, Ashvini Kumar Dubey, Amir Khan, Anurag Tiwari, Santosh Kumar, Shivani Patel, Nikitha M
  • Patent number: 11267899
    Abstract: The present disclosure relates to methods of obtaining cell with disrupted fucosylation and obtaining afucosylated protein. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology in a protein producing cell line to produce afucosylated protein. The resulting protein, specifically the resulting monoclonal antibody is completely afucosylated and reveals higher degree of antibody dependent cellular cytotoxicity.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: March 8, 2022
    Assignee: Zumutor Biologics Inc.
    Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Divya Unnikrishnan, Jahnabi Hazarika, Yogendra Manjunath Bangalore Muniraju, Sathyabalan Murugesan, Pavithra Mukunda, Bhargav Prasad, Veeresha Kamanagowda, Sanghamitra Bhattacharjee, Pravin Kumar Dakshinamurthy, Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar Natarajan, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath Ravindra Shenoy, Sahana Bhima Rao, Subhra Prakash Chakrabarty, Ashvini Kumar Dubey, Amir Khan, Ankurina Sharma
  • Patent number: 11230706
    Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a synthetic antibody gene expression library built on pool of consensus nucleic acid sequences by using codon replacement technology. The present disclosure also relates to a synthetic antibody library generated by employing the method of the present disclosure and application(s) of said antibody library.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: January 25, 2022
    Assignee: ZUMUTOR BIOLOGICS, INC.
    Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Divya Unnikrishnan, Yogendra Manjunath Bangalore Muniraju, Sathyabalan Murugesan, Pavithra Mukunda, Bhargav Prasad, Veeresha Kamanagowda, Sanghamitra Bhattacharjee, Pravin Kumar Dakshinamurthy, Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar Natarajan, Karthika Nair, Aswini Thanigaivel, Maliwalave Amol, Bharath Ravindra Shenoy, Sahana Bhima Rao, Subhra Prakash Chakrabarty, Ashvini Kumar Dubey, Amir Khan, Ankurina Sharma, Rashmi Sharma, Anurag Tiwari, Santosh Kumar, Shivani Patel, Nikitha Markanda
  • Publication number: 20200339666
    Abstract: The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and non-fucosylated protein products, specifically antibodies from the cell. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. The method of the present disclosure targets the Fut8 gene and GMD gene in a cell. Such products are used in developing therapeutics and biomarkers, and in diagnosis and prognosis of diseases.
    Type: Application
    Filed: July 6, 2020
    Publication date: October 29, 2020
    Inventors: Bhargav Prasad, Divya Unnikrishnan, Jahnabi Hazarika, Kavitha Iyer Rodrigues, Maloy Ghosh, Pavithra M, Pravin Kumar D, Sanghamitra Bhattacharjee, Sathyabalan M, Sankaranarayanan Srinivasan, Sohang Chatterjee, Sunit Maity, Veeresha K, Vivek Halan, Yogendra Manjunath B.M., Anuradha Hora, Bairavabalakumar N, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath R Shenoy, Rajeshwari Pendse, Prabhat Kumar Pathak, Anisha Kurup, Sahana Bhima Rao
  • Publication number: 20200291120
    Abstract: The present disclosure relates to novel anti-CLEC2D antibodies and related compositions and methods of use thereof. These antibodies are used as therapeutics, and in prognostic and diagnostic applications in various cancers and other diseases.
    Type: Application
    Filed: February 10, 2020
    Publication date: September 17, 2020
    Inventors: Kavitha Iyer RODRIGUES, Maloy GHOSH, Sunit MAITY, Yogendra Manjunath Bangalore MUNIRAJU, Sathyabalan MURUGESAN, Sanghamitra BHATTACHARJEE, Vivek HALAN, Subhra Prakash CHAKRABARTY, Ashvini Kumar DUBEY, Anurag TIWARI, Kirthana Mysore Vasudevarao SINDHE, Pallavi LAHIRI, Sahana Bhima RAO, Prachi, Shruti SRIVASTAVA, Rao Shreesha RAMESH, Bharath Ravindra SHENOY, Nikitha MARKANDA, Bhagyashree DIKEY, Bairavabalakumar NATARAJAN
  • Publication number: 20200283757
    Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a human naïve antibody gene expression library encompassing a pool of nucleic acid sequences derived from a natural antibody repertoire comprising humoral immunity from healthy and genetically diverse human populations. More specifically, the method employs a combination of phage and/or yeast antibody surface display concept which allows to screen large antibody library size and facilitates better folding of antibody structure. The present disclosure also relates to a human naïve antibody library generated by employing the process of the present disclosure, a set of primers employed in the method and application(s) of said antibody library.
    Type: Application
    Filed: December 21, 2015
    Publication date: September 10, 2020
    Inventors: Sohang CHATTERJEE, Kavitha Iyer RODRIGUES, Maloy GHOSH, Sunit MAITY, Divya UNNIKRISHNAN, Yogendra Manjunath BANGALORE MUNIRAJU, Sathyabalan MURUGESAN, Pavithra MUKUNDA, Bhargav PRASAD, Veeresha KAMANAGOWDA, Sanghamitra BHATTACHARJEE, Pravin Kumar DAKSHINAMURTHY, Vivek HALAN, Sankaranarayanan SRINIVASAN, Anuradha HORA, Bairavabalakumar NATARAJAN, Karthika NAIR, Aswini THANIGAIVEL, Amol MALIWALAVE, Bharath Ravindra SHENOY, Sahana Bhima RAO, Subhra Prakash CHAKRABARTY, Ashvini Kumar DUBEY, Amir KHAN, Anurag TIWARI, Santosh KUMAR, Shivani PATEL, Nikitha M
  • Patent number: 10752674
    Abstract: The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and non-fucosylated protein products, specifically antibodies from the cell. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. The method of the present disclosure targets the Fut8 gene and GMD gene in a cell. Such products are used in developing therapeutics and biomarkers, and in diagnosis and prognosis of diseases.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: August 25, 2020
    Assignee: Zumutor Biologics Inc.
    Inventors: Bhargav Prasad, Divya Unnikrishnan, Jahnabi Hazarika, Kavitha Iyer Rodrigues, Maloy Ghosh, Pavithra M, Pravin Kumar D, Sanghamitra Bhattacharjee, Sathyabalan M, Sankaranarayanan Srinivasan, Sohang Chatterjee, Sunit Maity, Veeresha K, Vivek Halan, Yogendra Manjunath B. M., Anuradha Hora, Bairavabalakumar N, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath R Shenoy, Rajeshwari Pendse, Prabhat Kumar Pathak, Anisha Kurup, Sahana Bhima Rao
  • Publication number: 20200149032
    Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a synthetic antibody gene expression library built on pool of consensus nucleic acid sequences by using codon replacement technology. The present disclosure also relates to a synthetic antibody library generated by employing the method of the present disclosure and application(s) of said antibody library.
    Type: Application
    Filed: January 19, 2017
    Publication date: May 14, 2020
    Inventors: Sohang CHATTERJEE, Kavitha IYER RODRIGUES, Maloy GHOSH, Sunit MAITY, Divya UNNIKRISHNAN, Yogendra MANJUNATH BANGALORE MUNIRAJU, Sathyabalan MURUGESAN, Pavithra MUKUNDA, Bhargav PRASAD, Veeresha KAMANAGOWDA, Sanghamitra BHATTACHARJEE, Pravin KUMAR DAKSHINAMURTHY, Vivek HALAN, Sankaranarayanan SRINIVASAN, Anuradha HORA, Bairavabalakumar NATARAJAN, Karthika NAIR, Aswini THANIGAIVEL, MALIWALAVE Amol, Bharath RAVINDRA SHENOY, Sahana BHIMA RAO, Subhra PRAKASH CHAKRABARTY, Ashvini KUMAR DUBEY, Amir KHAN, Ankurina SHARMA, Rashmi SHARMA, Anurag TIWARI, Santosh KUMAR, Shivani PATEL, Nikitha MARKANDA
  • Publication number: 20190119691
    Abstract: The present disclosure relates to vectors for cloning and expressing genetic material including but not limiting to antibody gene or parts thereof and methods of generating said vectors. Said vectors express the antibody genes in different formats such as Fab or scFv as a part of intertransfer system, intratransfer system or direct cloning and expression in individual display systems. In particular, phage display technology is used to clone and screen potential antibody genes in phagemid which is followed by the transfer of said genes to yeast vector for further screening and identification of lead molecules against antigens. The present vectors have numerous advantages including uniquely designed inserts/expression cassettes resulting in efficient and smooth transfer of clonal population from phage to yeast vectors resulting in efficient library preparation and identification of lead molecules.
    Type: Application
    Filed: April 6, 2017
    Publication date: April 25, 2019
    Inventors: Sohang CHATTERJEE, Kavitha Iyer RODRIGUES, Maloy GHOSH, Sunit MAITY, Divya UNNIKRISHNAN, Yogendra Manjunath Bangalore MUNIRAJU, Sathyabalan MURUGESAN, Pavithra MUKUNDA, Bhargav PRASAD, Veeresha KAMANAGOWDA, Sanghamitra BHATTACHARJEE, Pravin Kumar DAKSHINAMURTHY, Vivek HALAN, Sankaranarayanan SRINIVASAN, Anuradha HORA, Bairavabalakumar NATARAJAN, Karthika NAIR, Aswini THANIGAIVEL, Amol MALIWALAVE, Bharath Ravindra SHENOY, Sahana Bhima RAO, Subhra Prakash CHAKRABARTY, Ashvini Kumar DUBEY, Amir KHAN, Ankurina SHARMA, Rashmi SHARMA, Anurag TIWARI, Santosh KUMAR, Shivani PATEL, Nikitha M
  • Publication number: 20190112358
    Abstract: The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and non-fucosylated protein products, specifically antibodies from the cell. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. The method of the present disclosure targets the Fut8 gene and GMD gene in a cell. Such products are used in developing therapeutics and biomarkers, and in diagnosis and prognosis of diseases.
    Type: Application
    Filed: November 13, 2015
    Publication date: April 18, 2019
    Inventors: Bhargav Prasad, Divya Unnikrishnan, Jahnabi Hazarika, Kavitha Iyer Rodrigues, Maloy Ghosh, Pavithra M, Pravin Kumar D, Sanghamitra Bhattacharjee, Sathyabalan M, Sankaranarayanan Srinivasan, Sohang Chatterjee, Sunit Maity, Veeresha K, Vivek Halan, Yogendra Manjunath B. M., Anuradha Hora, Bairavabalakumar N, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath R Shenoy, Rajeshwari Pendse, Prabhat Kumar Pathak, Anisha Kurup, Sahana Bhima Rao
  • Patent number: 10077434
    Abstract: The present disclosure relates to developing cell lines where specific biological pathways are modified, particularly by modifications in the enzymes of the cell. The present disclosure develops protein expression systems wherein specific modification of glycan chain of the protein is achieved, which produces non-fucosylated proteins, including non-fucosylated antibodies. The non-fucosylated proteins are used in developing therapeutic monoclonal antibodies and biomarkers, and in diagnosis and prognosis of various diseases. The present disclosure employs the Transcription Activator like Effector Nuclease (TALEN) technology for inactivating fucosylation in a cell.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: September 18, 2018
    Assignee: Zumutor Biologics Inc.
    Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Rajeshwari Pendse, Divya Unnikrishnan, Yogendra Manjunath B. M., Jahnabi Arika, Sathyabalan M., Pavithra M., Bhargav Prasad, Veeresha K., Prabhat Kumar Pathak, Sanghamitra Bhattacharjee, Pravin Kumar D., Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar N., Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath R. Shenoy, Anisha Kurup
  • Publication number: 20180171028
    Abstract: The present disclosure relates to methods of obtaining cell with disrupted fucosylation and obtaining afucosylated protein. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology in a protein producing cell line to produce afucosylated protein. The resulting protein, specifically the resulting monoclonal antibody is completely afucosylated and reveals higher degree of antibody dependent cellular cytotoxicity.
    Type: Application
    Filed: May 13, 2016
    Publication date: June 21, 2018
    Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Divya Unnikrishnan, Jahnabi Hazarika, Yogendra Manjunath Bangalore Muniraju, Sathyabalan Murugesan, Pavithra Mukunda, Bhargav Prasad, Veeresha Kamanagowda, Sanghamitra Bhattacharjee, Pravin Kumar Dakshinamurthy, Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar Natarajan, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath Ravindra Shenoy, Sahana Bhima Rao, Subhra Prakash Chakrabarty, Ashvini Kumar Dubey, Amir Khan, Ankurina Sharma
  • Publication number: 20170306305
    Abstract: The present disclosure relates to developing cell lines where specific biological pathways are modified, particularly by modifications in the enzymes of the cell. The present disclosure develops protein expression systems wherein specific modification of glycan chain of the protein is achieved, which produces non-fucosylated proteins, including non-fucosylated antibodies. The non-fucosylated proteins are used in developing therapeutic monoclonal antibodies and biomarkers, and in diagnosis and prognosis of various diseases. The present disclosure employs the Transcription Activator like Effector Nuclease (TALEN) technology for inactivating fucosylation in a cell.
    Type: Application
    Filed: July 30, 2015
    Publication date: October 26, 2017
    Applicant: Zumator Biologics, Inc.
    Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Rajeshwari Pendse, Divya Unnikrishnan, Yogendra Manjunath B. M., Jahnabi Arika, Sathyabalan M., Pavithra M., Bhargav Prasad, Veeresha K., Prabhat Kumar Pathak, Sanghamitra Bhattacharjee, Pravin Kumar D., Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar N., Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath R. Shenoy, Anisha Kurup