Patents by Inventor Vivek Kumbhari

Vivek Kumbhari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Endoscopic gastric mucosal ablation/resection/exclusion (A/R/E) as a minimally invasive weight loss approach
    Patent number: 11147578
    Abstract: The present invention is directed to a method of endoscopically ablating/resecting/excluding (A/R/E) the mucosa of the gastric fundus and body. The method of the present invention is intended to cause cellular death to the X/A-like, ghrelin producing and other hormone cells. This is in contrast to present methods to provide only transient ischemia. The use of the method of the present invention results in a more permanent and robust method of reducing ghrelin and other hormone levels. In addition, a method according to the present invention can be used to induce scarring of the gastric fundus which will reduce gastric accommodation of excess food and result in early satiety.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: October 19, 2021
    Assignee: The Johns Hopkins University
    Inventors: Vivek Kumbhari, Anthony N. Kalloo, Mouen A. Khashab, Andreas Oberbach
  • ORGAN DIRECTED GENE DELIVERY
    Publication number: 20200345867
    Abstract: Intrabiliary hydrodynamic injection of nucleic acid for in vivo gene therapy for treatment of liver or pancreas disease and other disorders.
    Type: Application
    Filed: April 30, 2020
    Publication date: November 5, 2020
    Inventors: Florin M. Selaru, Vivek Kumbhari, Ling Li
  • ENDOSCOPIC GASTRIC MUCOSAL ABLATION/RESECTION/EXCLUSION (A/R/E) AS A MINIMALLY INVASIVE WEIGHT LOSS APPROACH
    Publication number: 20170367723
    Abstract: The present invention is directed to a method of endoscopically ablating/resecting/excluding (A/R/E) the mucosa of the gastric fundus and body. The method of the present invention is intended to cause cellular death to the X/A-like, ghrelin producing and other hormone cells. This is in contrast to present methods to provide only transient ischemia. The use of the method of the present invention results in a more permanent and robust method of reducing ghrelin and other hormone levels. In addition, a method according to the present invention can be used to induce scarring of the gastric fundus which will reduce gastric accommodation of excess food and result in early satiety.
    Type: Application
    Filed: December 8, 2015
    Publication date: December 28, 2017
    Inventors: Anthony N. Kalloo, Mouen A. Khashab, Vivek Kumbhari, Andreas Oberbach
  • Dual Balloon Biliary Stone Extraction Device
    Publication number: 20150150572
    Abstract: The present invention is directed to a method and apparatus for selective guide wire cannulation of a bile duct, removal of biliary calculi, and delivering hydrodynamic gene delivery are also provided. There is provided a method for straightening the terminal common bile duct to allow biliary calculi to be removed, assisting in creation of a gastoejunostomy, and selective guidewire cannulation. A method for isolating a segment of biliary epithelium for hydrodynamic gene delivery is also provided, in which a segment of the bile duct is isolated and plasmids (oncogenic or therapeutic) are injected under pressure to allow entry into cholangiocytes. There is also provided a method for isolating the cystic duct or left/right intrahepatic ducts to allow the insertion of a guide wire and subsequent therapy. A single catheter platform may be used to perform the above procedures.
    Type: Application
    Filed: December 4, 2014
    Publication date: June 4, 2015
    Inventors: Vivek Kumbhari, Mouen Khashab, Florin Selaru