Patents by Inventor Vivek Mittal

Vivek Mittal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9927444
    Abstract: Methods of determining cancer progression or cancer relapse in a subject at risk for cancer progression or cancer relapse, the methods comprising: obtaining a sample from said subject; measuring the level of VEGFR1+ hematopoietic progenitor cells (HPCs) and/or VEGFR2+ endothelial progenitor cells (EPCs) in said sample; and taking additional samples and conducting additional measurements of HPCs and/or EPCs at one or more later time points. From the measurements, it can be determined whether there is a surge in the level of HPCs and/or EPCs in at least one later measurement, relative to an earlier measurement. A surge in the level of HPCs and/or EPCs indicates increased risk of progression or relapse of said subject's cancer.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: March 27, 2018
    Assignee: Cornell University
    Inventors: Linda Vahdat, Shahin Rafii, Rakhi Naik, Maureen Lane, Vivek Mittal
  • Patent number: 9512425
    Abstract: As described herein, increased expression of microRNA-708 reduces migration and metastasis of cancer cells.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: December 6, 2016
    Assignee: Cornell University
    Inventors: Vivek Mittal, Seongho Ryu
  • Publication number: 20150275210
    Abstract: As described herein, increased expression of microRNA-708 reduces migration and metastasis of cancer cells.
    Type: Application
    Filed: October 23, 2013
    Publication date: October 1, 2015
    Inventors: Vivek MITTAL, Seongho RYU
  • Publication number: 20150017091
    Abstract: The establishment and growth of metastatic tumors can be detected and inhibited by the methods and compositions described herein. As illustrated herein, agents that inhibit the expression or activity of versican, for example, in bone marrow cells effectively halt the growth and establishment of metastatic tumors at distal sites from a primary tumor site. In general, the primary tumor is unaffected by versican inhibitors but metastasis is substantially eliminated.
    Type: Application
    Filed: August 16, 2012
    Publication date: January 15, 2015
    Inventors: Vivek Mittal, Ding Cheng Gao
  • Patent number: 8865159
    Abstract: This invention provides methods of treating tumors and other conditions characterized by abnormal neoangiogenesis by inhibiting bone marrow-derived endothelial progenitor cells.
    Type: Grant
    Filed: January 4, 2008
    Date of Patent: October 21, 2014
    Assignee: Cold Spring Harbor Laboratory
    Inventors: Vivek Mittal, Daniel J. Nolan, Dingcheng Gao, Albert S. Mellick
  • Publication number: 20140134190
    Abstract: Methods of determining cancer progression or cancer relapse in a subject at risk for cancer progression or cancer relapse, the methods comprising: obtaining a sample from said subject; measuring the level of VEGFR1+ hematopoietic progenitor cells (HPCs) and/or VEGFR2+ endothelial progenitor cells (EPCs) in said sample; and taking additional samples and conducting additional measurements of HPCs and/or EPCs at one or more later time points. From the measurements, it can be determined whether there is a surge in the level of HPCs and/or EPCs in at least one later measurement, relative to an earlier measurement. A surge in the level of HPCs and/or EPCs indicates increased risk of progression or relapse of said subject's cancer.
    Type: Application
    Filed: February 24, 2012
    Publication date: May 15, 2014
    Applicant: Cornell University
    Inventors: Linda Vahdat, Shahin Rafii, Rakhi Naik, Maureen Lane, Vivek Mittal
  • Publication number: 20100284907
    Abstract: This invention provides methods of treating tumors and other conditions characterized by abnormal neoangiogenesis by inhibiting bone marrow-derived endothelial progenitor cells.
    Type: Application
    Filed: January 4, 2008
    Publication date: November 11, 2010
    Inventors: Vivek Mittal, Daniel J. Nolan, Dingcheng Gao, Albert S. Mellick
  • Publication number: 20080300145
    Abstract: In mammalian systems, RNA interference (RNAi)-based suppression of target gene expression may be activated by delivery of RNAi probes such as double stranded small interfering RNA (siRNA) molecules or short hairpin RNAs (shRNAs), where the RNAi probe sequence is homologous to the target-gene. A reliable and quantitative method is provided for the rapid and efficient identification of RNAi probes that are most effective in providing RNAi-mediated suppression of target gene expression. This method may be used for high-throughput screens to identify effective RNAi probes.
    Type: Application
    Filed: October 30, 2007
    Publication date: December 4, 2008
    Applicant: Cold Spring Harbor Laboratory
    Inventors: Vivek Mittal, Rajeev Kumar
  • Publication number: 20050164210
    Abstract: The invention provides, among other things, regulated polymerase III expression systems and related compositions. The invention provides, in part, expression systems in which the expression is inducible, and systems which express inhibitory RNA molecules, such as hairpin RNA molecules. The invention also provides related methods, such as methods of inhibiting expression of a gene.
    Type: Application
    Filed: January 23, 2004
    Publication date: July 28, 2005
    Inventors: Vivek Mittal, Sunita Gupta, Gregory Hannon, Patrick Paddison, Eric Julien, Winship Herr
  • Publication number: 20050042641
    Abstract: In mammalian systems, RNA interference (RNAi)-based suppression of target gene expression may be activated by delivery of RNAi probes such as double stranded small interfering RNA (siRNA) molecules or short hairpin RNAs (shRNAs), where the RNAi probe sequence is homologous to the target gene. A reliable and quantitative method is provided for the rapid and efficient identification of RNAi probes that are most effective in providing RNAi-mediated suppression of target gene expression. This method may be used for high-throughput screens to identify effective RNAi probes.
    Type: Application
    Filed: May 25, 2004
    Publication date: February 24, 2005
    Applicant: Cold Spring Harbor Laboratory
    Inventors: Vivek Mittal, Rajeev Kumar