Abstract: A minimally invasively implanted anchor support for securing a medical device to a heart wall including an anchoring member and an expandable distal anchor retraint which is implanted through the anchoring member, through the heart wall, and expands on the opposing heart wall side to anchor a medical device. A single-stage anchor system includes the distal flange and a two-stage anchor system includes the distal flange and a proximal flange which cooperates with the distal flange to secure a medical device to the heart wall and methods of a single-stage anchor system and a two-stage anchor system.

Abstract: A minimally invasive and steerable leaflet grasper for intracardiac implantation into a heart chamber for grasping a heart leaflet and modifying the leaflet. The leaflet grasper includes a proximal control knob for controlling the distal grasping end of the leaflet grasper having a grasping arm, gripper, and laceration element for securing the leaflet and modifying the leaflet. The method includes using a single leaflet grasper to secure and lacerate the leaflet.

Abstract: A method of endovascularly delivering and implanting a medical assembly for minimally invasively implanting an atrial sealing skirt in the heart at an atrial sealing skirt deployment site, sealing the top brim against a respective atrial floor of the heart, and anchoring the atrial sealing skirt on an intracardiac wall at an implantation site and tethering the anchor and the sealing skirt.

Abstract: A medical assembly and methods for endovascularly implanting a valve in the heart having a valve and an anchor assembly for positioning and restraining the valve. An anchor delivery system introduces and implants the anchor into the implantation site and a valve delivery system introduces and seals the valve at the deployment site. The present invention also relates to methods of implantation of the medical assembly and the valve.

Abstract: A minimally invasively implanted anchor support for securing a medical prosthesis device with a tether to an implanted anchor. The anchor support includes a lock cap for connecting to the anchor, a tether swivel connected to the lock cap, a tock cone within the tether swivel and a tether collar on a proximal end of the tether swivel. An anchor support delivery system cooperates with the anchor support for securing to the lock cap.

Abstract: An endovascular medical assembly and method for restoring chordal support to a leaflet of a heart valve by implanting artificial chordae tendinea in the heart. A chord is inserted into the heart endovascularly with a leaflet grasper which pierces the leaflet and implants the chord through the leaflet. An anchor assembly is implanted into an intracardiac wall and has anchor lines extending therefrom. The chord and an anchor line are assembled by a line gathering member and the tension of the chord is adjusted and secured. The chord is, thus, secured to the anchor assembly to support the leaflet.

Abstract: A medical assembly implanting a transcatheter heart valve in the heart at a valve deployment site and related methods of implantation and delivery. An anchor is endovascularly introduced into the heart and implanted to a cardiac wall with an anchor delivery system and delivery cable. A second delivery system introduces a tether which coupled to the implanted anchor and a transcatheter heart valve. The transcatheter heart valve includes either a top or bottom brim which is positioned to conform to the atrial floor at the deployment site.

Abstract: A medical assembly implanting a transcatheter heart valve in the heart at a valve deployment site and related methods of implantation and delivery. An anchor is endovascularly introduced into the heart and implanted to a cardiac wall with an anchor delivery system and delivery cable. A second delivery system introduces a tether which coupled to the implanted anchor and a transcatheter heart valve. The transcatheter heart valve includes either a top or bottom brim which is positioned to conform to the atrial floor at the deployment site.

Abstract: A minimally invasively implanted anchor support for securing a medical prosthesis device with a tether to an implanted anchor. The anchor support includes a lock cap for connecting to the anchor, a tether swivel connected to the lock cap, a tock cone within the tether swivel and a tether collar on a proximal end of the tether swivel. An anchor support delivery system cooperates with the anchor support for securing to the lock cap.

Abstract: A tether locking assembly for implanted cardiac medical devices, such as an artificial heart valve to replace the native heart valve, and which are secured at the implantation site by anchoring tethers secured to an intracardiac member, such as an intracardiac wall. The tether locking assembly includes at least one atrial positioning rod, at least one conduit, and a detachable lock. The detachable lock includes first and second hypotubes and a locking clip. The hypotubes are positioned within the positioning rod central lumen.

Abstract: Anchor assemblies for endovascular introduction and implantation for tethering a replacement heart valve to a cardiac wall. An anchor delivery system introduces the assembly. The anchor may be either implanted with a tether connected thereto or implanted and then connected to a tether. If the latter, a tether assembly is mounted to the implanted anchor to connect the anchor to the valve. The anchors may be implanted into any cardiac wall including the interventricular septum or the epicardial space and the valve may replace the mitral or tricuspid valve.

Abstract: Anchor assemblies for endovascular introduction and implantation for tethering a replacement heart valve to a cardiac wall. An anchor delivery system introduces the assembly. The anchor may be either implanted with a tether connected thereto or implanted and then connected to a tether. If the latter, a tether assembly is mounted to the implanted anchor to connect the anchor to the valve. The anchors may be implanted into any cardiac wall including the interventricular septum or the epicardial space and the valve may replace the mitral or tricuspid valve.

Abstract: An atrial sealing skirt for transcatheter valves and an atrial sealing skirt with an integrated valve to reduce paravalvular regurgitation, with or without the presence of intracardiac leads. The atrial sealing skirt includes a top brim which is positioned to conform to the atrial floor at the deployment site.

Abstract: A minimally invasively implanted anchor support for securing a medical device to a heart wall including an anchoring member and an expandable distal anchor restraint which is implanted through the anchoring member, through the heart wall, and expands on the opposing heart wall side to anchor a medical device. A single-stage anchor system includes the distal flange and a two-stage anchor system includes the distal flange and a proximal flange which cooperates with the distal flange to secure a medical device to the heart wall and methods of a single-stage anchor system and a two-stage anchor system.

Abstract: An endovascular medical assembly and method for restoring chordal support to a leaflet of a heart valve by implanting artificial chordae tendinea in the heart. A chord is inserted into the heart endovascularly with a leaflet grasper which pierces the leaflet and implants the chord through the leaflet. An anchor assembly is implanted into an intracardiac wall and has anchor lines extending therefrom. The chord and an anchor line are assembled by a line gathering member and the tension of the chord is adjusted and secured. The chord is, thus, secured to the anchor assembly to support the leaflet.

Abstract: A method for endovascularly implanting a valve in the heart having a medical assembly including a replacement heart valve and an anchor assembly for positioning and restraining the valve. The method includes endovascularly introducing an anchor delivery system for anchoring the heart valve to replace the native heart valve and for endovascularly introducing a valve delivery systems for implanting the valve at the implantation site to replace a native heart valve.

Abstract: A medical assembly for endovascularly implanting a valve in the heart having a valve and a valve delivery systems for implanting and securing the valve. The valve delivery system introduces and seals the valve at the deployment site.

Abstract: A method of endovascularly delivering and implanting a medical assembly for minimally invasively implanting an atrial sealing skirt in the heart at an atrial sealing skirt deployment site, sealing the top brim against a respective atrial floor of the heart, and anchoring the atrial sealing skirt on an intracardiac wall at an implantation site and tethering the anchor and the sealing skirt.

Abstract: A medical assembly and methods for endovascularly implanting a valve in the heart having a valve and an anchor assembly for positioning and restraining the valve. An anchor delivery system introduces and implants the anchor into the implantation site and a valve delivery system introduces and seals the valve at the deployment site. The present invention also relates to methods of implantation of the medical assembly and the valve.

Abstract: A medical assembly implanting an atrial sealing skirt in the heart at an atrial sealing skirt deployment site and related methods of implantation and delivery. An anchor is endovascularly introduced into the heart and implanted to a cardiac wall with an anchor delivery system and delivery cable. A second delivery system introduces a tether which coupled to the implanted anchor and an atrial sealing skirt. The atrial sealing skirt includes a top brim which is positioned to conform to the atrial floor at the deployment site. The sealing skirt may be integrated with a valve or serve as a receptacle.