Patents by Inventor Vivekananda Bal

Vivekananda Bal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PURIFICATION OF RECOMBINANT ADENO-ASSOCIATED VIRUS VECTORS FOR GENE THERAPY
    Publication number: 20240409957
    Abstract: Methods of purifying full capsids of recombinant adeno-associated virus vectors (rAAVs) from a solution containing a mixture of full and empty capsids are described. Typically, methods use crystallization reagents and conditions that preferentially crystalize full rAAV capsids over empty rAAV capsids. Specifically, crystallization reagents and conditions that preferentially crystalize full rAAV5 or rAAV8 capsids over their corresponding empty rAAV capsids are described. The resulting crystals containing mostly or exclusively full rAAV capsids are particularly suited for use in gene therapy. Methods of storing and reconstituting the crystals of full rAAV capsids in preparation for administering to a subject in need thereof are also provided.
    Type: Application
    Filed: June 3, 2024
    Publication date: December 12, 2024
    Inventors: Vivekananda Bal, Anthony J. Sinskey, Paul W. Barone, Richard D. Braatz, Stacy L. Springs