Patents by Inventor Vivian A. Fonseca

Vivian A. Fonseca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250064978
    Abstract: Provided are recombinant adeno-associated virus (rAAV) vectors comprising a transgene to express Pax4; virions comprising said vectors (rAAV virions); methods of their production; methods of their use, including methods for treating diabetes, increasing insulin production and transdifferentiating ?-cells to ?-cells; pharmaceutical compositions and kits including same.
    Type: Application
    Filed: November 30, 2022
    Publication date: February 27, 2025
    Inventors: Michael Hughes, Sandeep Dhall, Hongju Wu, Vivian A. Fonseca
  • Publication number: 20190357853
    Abstract: The present disclosure provides for diabetes risk engine systems and methods for predicting diabetes progression and mortality in a patient with type 2 diabetes mellitus, for the U.S. population, including the building, relating, assessing, and validating outcomes (BRAVO) risk engine. The BRAVO risk engine includes a diabetes-related events module to predict an occurrence of one or more events, a risk factors module to predict a progression of risk factors, a mortality module to predict an occurrence of mortality, and a display interface configured to display the predicted risk of diabetes-related events or mortality. Risk equations for predicting diabetes-related microvascular and macrovascular events, hypoglycemia, mortality, and progression of diabetes risk factors were estimated using the data from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. The BRAVO risk engine preferably includes risk factors including severe hypoglycemia and common U.S.
    Type: Application
    Filed: May 24, 2019
    Publication date: November 28, 2019
    Inventors: Lizheng Shi, Vivian A. Fonseca, Hui Shao
  • Publication number: 20080306126
    Abstract: A method of lowering homocysteine level of an individual and of reducing the vascular pathology associated therewith, by administering a ligand of the peroxisome proliferator activate receptor gamma. The peroxisome proliferator activated receptor preferably may be rosiglitazone.
    Type: Application
    Filed: January 4, 2005
    Publication date: December 11, 2008
    Inventors: Vivian A. Fonseca, Dennis B. McNamara