Patents by Inventor Vivian Hook

Vivian Hook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240181068
    Abstract: Pharmaceutical compositions comprising a peptidic inhibitor of cathepsin B, such as Z-Arg-Lys-AOMK (Z-R-K-AOMK). Methods for inhibiting neutral pH cathepsin B activity, comprising administering to a subject in need an effective amount of a peptidic inhibitor of cathepsin B. Methods for treatment or prevention of a disease comprising administering to a subject in need an effective amount of a peptidic inhibitor of cathepsin B. Methods of producing pH-selective peptide-AMC substrates and novel peptidic-AOMK inhibitors of cathepsin B.
    Type: Application
    Filed: February 17, 2022
    Publication date: June 6, 2024
    Inventors: Anthony O'Donoghue, Vivian Hook, Michael Yoon, Dennis Wolan
  • Publication number: 20100216875
    Abstract: The invention is directed to a method of treating Alzheimer's disease. The method comprises administering a cysteine protease inhibitor to a patient and thereby affecting the disease. In a preferred method, the cysteine protease inhibitor is a cathepsin B inhibitor. A preferred method causes a reversal in the progression of the Alzheimer's disease, especially an improvement in cognitive deficit. A preferred method also causes a reduction in A?. The method includes using a reversible or irreversible cysteine protease inhibitor or a combination thereof.
    Type: Application
    Filed: December 17, 2007
    Publication date: August 26, 2010
    Inventors: Gregory Hook, Vivian Hook, Robert Ternansky