Patents by Inventor Viviane Van Dorsselaer

Viviane Van Dorsselaer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzimidazole derivatives, preparation and therapeutic use thereof
    Publication number: 20030203893
    Abstract: The invention relates to benzimidazole derivatives of general formula 1
    Type: Application
    Filed: January 30, 2003
    Publication date: October 30, 2003
    Inventors: Francis Barth, Daniel Bichon, Frank Bolkenius, Viviane Van Dorsselaer
  • Difluoro statone analogs
    Patent number: 6114380
    Abstract: This invention relates to novel difluoro statone analogs, to the processes and intermediates useful for their preparation and to their use as anti-viral agents.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: September 5, 2000
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Daniel Schirlin, Viviane Van Dorsselaer, Celine Tarnus
  • Inhibitors of .beta.-amyloid protein production
    Patent number: 5977074
    Abstract: This invention relates to compounds and pharmaceutical compositions, and methods for inhibiting or preventing the amyloid protein deposits in the brain which are associated with Alzheimer's disease and aged Down's syndrome patients. More particularly, it relates to the treatment of Alzheimer's disease.
    Type: Grant
    Filed: March 28, 1996
    Date of Patent: November 2, 1999
    Assignee: Merrell Pharmaceuticals, Inc.
    Inventors: Barbara Cordell, Daniel Schirlin, Norton P. Peet, Jeffrey N. Higaki, Viviane Van Dorsselaer, Michael R. Angelastro
  • Difluoro statone antiviral analogs
    Patent number: 5948778
    Abstract: This invention relates to novel statone antiviral analogs, to the processes and intermediates useful for their preparation and to their use as antiviral agents.
    Type: Grant
    Filed: May 19, 1998
    Date of Patent: September 7, 1999
    Assignee: Merrel Pharmaceuticals Inc.
    Inventors: Viviane Van Dorsselaer, Daniel Schirlin, Celine Tarnus
  • Difluoro statone antiviral analogs
    Patent number: 5831094
    Abstract: The present invention relates to difluorostatone derivatives useful as antiviral agents.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: November 3, 1998
    Assignee: Merrell Pharamceuticals Inc.
    Inventors: Viviane Van Dorsselaer, Daniel Schirlin, Celine Tarnus
  • Difluoro statone analogs
    Patent number: 5717093
    Abstract: This invention relates to novel difluoro statone analogs, to the processes and intermediates useful for their preparation and to their use as anti-viral agents.
    Type: Grant
    Filed: December 18, 1995
    Date of Patent: February 10, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Daniel Schirlin, Viviane Van Dorsselaer, Celine Tarnus
  • Anti-viral compounds
    Patent number: 5716973
    Abstract: This invention relates to novel difluoro statone analogs, to the processes and intermediates useful for their preparation and to their use as anti-vital agents.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: February 10, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Daniel Schirlin, Viviane Van Dorsselaer, Celine Tarnus
  • Difluoro statone analogs
    Patent number: 5559140
    Abstract: This invention relates to novel difluoro statone analogs, to the processes and intermediates useful for their preparation and to their use as anti-viral agents.
    Type: Grant
    Filed: June 30, 1993
    Date of Patent: September 24, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Daniel Schirlin, Viviane Van Dorsselaer, Celine Tarnus
  • Decarboxylase-inhibiting fluorinated pentane diamine derivatives
    Patent number: 4446151
    Abstract: Novel fluorinated diamine derivatives are inhibitors of ornithine decarboxylase enzyme and have the following general Formula I: ##STR1## wherein: R.sub.c represents hydrogen or carboxy;R.sub.1 represents hydrogen or C.sub.1 -C.sub.6 alkyl;Z represents methylene or oxygen;m and n each represent 0 or 1 but m+n=1; andp represents 1 or 2.
    Type: Grant
    Filed: August 11, 1982
    Date of Patent: May 1, 1984
    Assignee: Merrell Toraude et Compagnie
    Inventors: Fritz Gerhart, Viviane Van Dorsselaer
  • Fluorinated diaminopentene derivatives
    Patent number: 4423073
    Abstract: Novel fluorinated alkenylene diamine derivatives are inhibitors of ornithine decarboxylase enzyme and have the following general Formula I: ##STR1## wherein: R.sub.c represents hydrogen or --COR.sub.5, where R.sub.5 is as defined below;R.sub.1 represents hydrogen or C.sub.1 -C.sub.6 alkyl;one of R.sub.2 and R.sub.3 represents hydrogen and the other represents C.sub.1 -C.sub.6 alkyl.R.sub.5 represents hydroxy or C.sub.1 -C.sub.8 alkoxy; andp represents 1 or 2.
    Type: Grant
    Filed: August 11, 1982
    Date of Patent: December 27, 1983
    Assignee: Merrell Toraude et Compagnie
    Inventors: Fritz Gerhart, Viviane Van Dorsselaer
  • Preparation of fluorinated methyl aminoalkanoic acids and novel process intermediates
    Patent number: 4353828
    Abstract: Fluorinated alkenylamines of the Formula V ##STR1## wherein n represents 0, 1, 2 or 3; R.sub.1 represents hydrogen or C.sub.1 -C.sub.10 alkyl and Y represents (a), when n represents O, CH.sub.2 F, (b), when n represents 1, CH.sub.2 F or CHF.sub.2, or (c) when n represents 2 or 3, CH.sub.2 F, CHF.sub.2 or CF.sub.3 are novel process intermediates. They are obtained by hydrolysis and subsequent reduction of the corresponding alkenyl fluorinated methyl ketimine magnesium halides, which are novel compounds resulting from reaction of the corresponding alkenyl magnesium halides with the corresponding fluorinated acetonitriles. The fluorinated alkenylamines of Formula V are oxidized while the amino group is protected to provide, after removal of the amine protecting group, the corresponding fluorinated methyl aminoalkanoic acids which are useful pharmacological or anti-bacterial agents.
    Type: Grant
    Filed: July 21, 1980
    Date of Patent: October 12, 1982
    Assignee: Merrell Toraude et Compagnie
    Inventors: Philippe Bey, Fritz Gerhart, Viviane Van Dorsselaer