Abstract: The invention relates to a process for the production of middle-distillate hydrocarbon-containing bases from a feedstock comprising butanol and pentanol, with said process comprising at least: a) Isomerizing dehydration of said feedstock; b) Separation of the water that is present in said olefinic effluent; c) Purification of the organic liquid effluent coming from b); d) Selective oligomerization of a feedstock that comprises at least a portion of the purified organic effluent coming from c), to produce a first oligomerization effluent; e) Oligomerization of said first oligomerization effluent in such a way as to produce a second oligomerization effluent; f) Fractionation of said second oligomerization effluent into at least three products, a light product, an intermediate product and a distillate product; g) Oligomerization of at least a portion of said intermediate product; h) Hydrogenation of at least a portion of said distillate product.