Patents by Inventor Viyyoor Girijavallabhan

Viyyoor Girijavallabhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
    Publication number: 20060173016
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: March 31, 2006
    Publication date: August 3, 2006
    Inventors: Timothy Guzi, Kamil Paruch, Michael Dwyer, Ronald Doll, Viyyoor Girijavallabhan, Lawrence Dillard, Vinh Tran, Zhen He, Ray James, Haengsoon Park
  • 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
    Publication number: 20060142338
    Abstract: In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17?-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with type 3 17?-hydroxysteroid dehydrogenase using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: February 23, 2006
    Publication date: June 29, 2006
    Inventors: Timothy Guzi, Yi-Tsung Liu, Ronald Doll, Anil Saksena, Viyyoor Girijavallabhan, Jonathan Pachter
  • Substituted 5-carboxyamide pyrazoles and [1,2,4]triazoles as antiviral agents
    Publication number: 20060111411
    Abstract: The present invention provides compounds of formula I wherein X, Y, R1-R7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders using these compounds and compositions are also provided.
    Type: Application
    Filed: October 26, 2005
    Publication date: May 25, 2006
    Inventors: Alan Cooper, Hugh Zhu, James Wang, Jagdish Desai, Gerald Shipps, Patrick Curran, D. Allen Annis, Huw Nash, Viyyoor Girijavallabhan
  • Substituted 5-oxo pyrazoles and [1,2,4]triazoles as antiviral agents
    Publication number: 20060111412
    Abstract: The present invention provides compounds of formula I wherein X and R1-R7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders using these compounds and compositions are also provided.
    Type: Application
    Filed: October 26, 2005
    Publication date: May 25, 2006
    Inventors: Gerald Shipps, Tong Wang, Kristin Rosner, Patrick Curran, Alan Cooper, Viyyoor Girijavallabhan
  • 17 Beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
    Publication number: 20060069103
    Abstract: There are disclosed compounds of the formula (I): prodrugs thereof, or pharmaceutically acceptable salts of the compounds or of said prodrugs which are useful as inhibitors of Type 3 17?-Hydroxysteroid Dehydrogenase. Also disclosed are pharmaceutical compositions containing said compounds and their use for the treatment or prevention of androgen dependent diseases.
    Type: Application
    Filed: November 14, 2005
    Publication date: March 30, 2006
    Inventors: Timothy Guzi, Kamil Paruch, Alan Mallams, Jocelyn Rivera, Ronald Doll, Viyyoor Girijavallabhan, Jonathan Pachter, Yi-Tsung Liu, Anil Saksena
  • Acylsulfonamide compounds as inhibitors of hepatitis C virus NS3 serine protease
    Publication number: 20060046956
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: August 25, 2005
    Publication date: March 2, 2006
    Inventors: Mousumi Sannigrahi, F. Njoroge, Viyyoor Girijavallabhan
  • Novel imidazopyridines as cyclin dependent kinase inhibitors
    Publication number: 20060030555
    Abstract: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: September 29, 2005
    Publication date: February 9, 2006
    Inventors: Michael Dwyer, Timothy Guzi, Kamil Paruch, Ronald Doll, Kartik Keertikar, Viyyoor Girijavallabhan
  • 17 Beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
    Publication number: 20060014755
    Abstract: There are disclosed compounds of the formula (I): prodrugs thereof, or pharmaceutically acceptable salts of the compounds or of said prodrugs which are useful as inhibitors of Type 3 17?-Hydroxysteroid Dehydrogenase. Also disclosed: are pharmaceutical compositions containing said compounds and their use for the treatment or prevention of androgen dependent diseases.
    Type: Application
    Filed: January 28, 2005
    Publication date: January 19, 2006
    Inventors: Timothy Guzi, Kamil Paruch, Alan Mallams, Jocelyn Rivera, Ronald Doll, Viyyoor Girijavallabhan, Jonathan Pachter, Yi-Tsung Liu, Anil Saksena
  • Novel compounds as inhibitors of hepatitis C virus NS3 serine protease
    Publication number: 20050288233
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: February 24, 2005
    Publication date: December 29, 2005
    Inventors: Srikanth Venkatraman, F. Njoroge, Melissa Blackman, Wanli Wu, Latha Nair, Ashok Arasappan, Stephane Bogen, Kevin Chen, Mousumi Sannigrahi, Frank Bennett, Viyyoor Girijavallabhan
  • Novel substituted prolines as inhibitors of hepatitis C virus NS3 serine protease
    Publication number: 20050272663
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: May 18, 2005
    Publication date: December 8, 2005
    Inventors: Ashok Arasappan, F. Njoroge, Viyyoor Girijavallabhan
  • Novel inhibitors of hepatitis C virus NS3 protease
    Publication number: 20050267043
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: February 24, 2005
    Publication date: December 1, 2005
    Inventors: Stephane Bogen, Weidong Pan, Sumei Ruan, Kevin Chen, Ashok Arasappan, Srikanth Venkatraman, Latha Nair, Mousumi Sannigrahi, Frank Bennett, Anil Saksena, F. Njoroge, Viyyoor Girijavallabhan
  • Novel compounds as inhibitors of hepatitis C virus NS3 serine protease
    Publication number: 20050245458
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: February 24, 2005
    Publication date: November 3, 2005
    Inventors: Ashok Arasappan, F. Njoroge, Angela Padilla-Acevedo, Kevin Chen, Frank Bennett, Mousumi Sannigrahi, Stephane Bogen, Srikanth Venkatraman, Edwin Jao, Anil Saksena, Viyyoor Girijavallabhan
  • Novel ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus
    Publication number: 20050222047
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: February 24, 2005
    Publication date: October 6, 2005
    Inventors: Kevin Chen, F. Njoroge, Mousumi Sannigrahi, Latha Nair, Weiying Yang, Bancha Vibulbhan, Srikanth Venkatraman, Ashok Arasappan, Stephane Bogen, Frank Bennett, Viyyoor Girijavallabhan
  • 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis C virus NS3 serine protease
    Publication number: 20050197301
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: February 24, 2005
    Publication date: September 8, 2005
    Inventors: F. Njoroge, Srikanth Venkatraman, Ashok Arasappan, Francisco Velazquez, Viyyoor Girijavallabhan
  • Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
    Publication number: 20050176648
    Abstract: The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: March 24, 2005
    Publication date: August 11, 2005
    Applicant: Schering-Plough Corporation
    Inventors: Anil Saksena, Viyyoor Girijavallabhan, Stephane Bogen, Raymond Lovey, Edwin Jao, Frank Bennett, Jinping McCormick, Haiyan Wang, Russell Pike, Yi-Tsung Liu, Tin-Yau Chan, Zhaoning Zhu, Ashok Arasappan, Kevin Chen, Srikanth Venkatraman, Tejal Parekh, Patrick Pinto, Bama Santhanam, F. Njoroge, Ashit Ganguly, Henry Vaccaro, Scott Kemp, Odile Levy, Marguerita Lim-Wilby, Susan Tamura
  • Depeptidized inhibitors of hepatitis C virus NS3 protease
    Publication number: 20050164921
    Abstract: The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: November 19, 2004
    Publication date: July 28, 2005
    Inventors: F. Njoroge, Srikanth Venkatraman, Viyyoor Girijavallabhan
  • Novel imidazopyrazines as cyclin dependent kinase inhibitors
    Publication number: 20050130980
    Abstract: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: January 31, 2005
    Publication date: June 16, 2005
    Inventors: Kamil Paruch, Timothy Guzi, Michael Dwyer, Ronald Doll, Viyyoor Girijavallabhan, Alan Mallams
  • Macrocyclic inhibitors of hepatitis C virus NS3-serine protease
    Publication number: 20050119168
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. The novel compounds typically include a 15-20 member macrocycle and have the general structure of structural Formula 1: wherein Z?, L?, M?, R1, X and D are defined herein.
    Type: Application
    Filed: September 23, 2004
    Publication date: June 2, 2005
    Inventors: Srikanth Venkatraman, F. Njoroge, Wanli Wu, Viyyoor Girijavallabhan, Brian McKittrick, Jing Su, Francisco Velazquez, Patrick Pinto
  • Novel peptidomimetic NS3-serine protease inhibitors of hepatitis C virus
    Publication number: 20050085425
    Abstract: The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: useful in the treatment or prevention or amelioration of one or more symptoms of hepatitis C.
    Type: Application
    Filed: August 24, 2004
    Publication date: April 21, 2005
    Inventors: Kevin Chen, F. Njoroge, Weiying Yang, Bancha Vibulbhan, Viyyoor Girijavallabhan, Srikanth Venkatraman, Francisco Velazquez
  • Novel farnesyl protein transferase inhibitors as antitumor agents
    Publication number: 20050059672
    Abstract: Disclosed are novel tricyclic compounds of the formula: and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are uses of the compounds of formula (I) for the manufacture of a medicament for the treatment of cancer.
    Type: Application
    Filed: August 4, 2004
    Publication date: March 17, 2005
    Inventors: Hugh Zhu, Alan Cooper, Jagdish Desai, James Wang, Dinanath Rane, Ronald Doll, F. Njoroge, Viyyoor Girijavallabhan