Patents by Inventor Vlad E. Gregor

Vlad E. Gregor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
    Patent number: 8063225
    Abstract: Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.
    Type: Grant
    Filed: August 10, 2007
    Date of Patent: November 22, 2011
    Assignee: Chembridge Corporation
    Inventors: Vlad E. Gregor, Yahua Liu, Alexey Anikin, Danny Peter Claude McGee, Charles Mikel, Douglas Eric McGrath, Goverdhan Reddy Vavilala, Jason C. Pickens, Alexander Kadushkin, Luyong Jiang, Mohan Santhanam Thiruvazhi, Sergey Zozulya, Rajendran Vairagoundar, Tong Zhu, Alexander Chucholowski, Thomas Webb, Vidyasagar Reddy Gantla, Zheng Yan
  • Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
    Publication number: 20080171769
    Abstract: Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.
    Type: Application
    Filed: August 10, 2007
    Publication date: July 17, 2008
    Inventors: Vlad E. Gregor, Yahua Liu, Alexey Anikin, Danny Peter Claude McGee, Charles Mikel, Douglas Eric McGrath, Goverdhan Reddy Vavilala, Jason C. Pickens, Alexander Kadushkin, Luyong Jiang, Mohan Santhanam Thiruvazhi, Sergey Zozulya, Rajendran Vairagoundar, Tong Zhu, Alexander Chucholowski, Thomas Webb, Vidyasagar Reddy Gantla, Zheng Yan
  • Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
    Patent number: 7223759
    Abstract: The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of using such compounds in the treatment of bacterial infections in mammals, especially humans.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: May 29, 2007
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Yuefen Zhou, Dionisios Vourloumis, Vlad E. Gregor, Geoffrey C. Winters, Thomas Hermann, Benjamin Ayida, Zhongxiang Sun, Douglas Murphy, Klaus B. Simonsen
  • Large scale sorption-driven solid state chromatography
    Patent number: 5811665
    Abstract: A system for preparative sorption driven chromatographic separation of organic compounds comprising a chromatographic element having a focusing zone in a porous tip with a vertex having a first diameter for receiving sample and solvent and a base having a wider second diameter, and an elongated resolving zone of at least the second diameter is disclosed. The system may further include a porous solvent transfer block for transferring solvent from a source to the tip. A method of chromatographically isolating an organic compound using the system is disclosed.
    Type: Grant
    Filed: September 11, 1996
    Date of Patent: September 22, 1998
    Assignee: Alanex Corporation
    Inventors: Vlad E. Gregor, Scott Schreckengaust
  • Quinazoline derivatives as acetylcholinesterase inhibitors
    Patent number: 5486512
    Abstract: A method of treating cognitive deficiencies is described by administering a quinazoline derivative of the general formula ##STR1## wherein A represents ##STR2## in which n is 1-10, P is a bond or (CH.sub.2).sub.m in which m is 0-10, and M is .dbd.O, .dbd.S, .dbd.NR, .dbd.CRR', ##STR3## novel compounds of the above are also described as well as methods of manufacture and pharmaceutical compositions.
    Type: Grant
    Filed: March 17, 1994
    Date of Patent: January 23, 1996
    Assignee: Warner-Lambert Company
    Inventor: Vlad E. Gregor
  • Substituted alpha-amino acids having pharmaceutical activity
    Patent number: 5175153
    Abstract: The present invention is novel substituted .alpha.-amino acids, pharmaceutical compositions, method of use, and preparations therefore having utility for treating disorders which benefit from blockade of aspartate and glutamate receptors.
    Type: Grant
    Filed: October 14, 1988
    Date of Patent: December 29, 1992
    Assignee: Warner-Lambert Company
    Inventors: Christopher F. Bigge, James T. Drummond, Vlad E. Gregor, Graham Johnson, Michael R. Pavia
  • Antibacterial benzo(chalcogeno)[4,3,2-cd]indazoles
    Patent number: 4604390
    Abstract: Substituted 2H-[1]benzopyrano[4,3,2-cd]indazoles, 2H-[1]benzothiopyrano[4,3,2-cd]indazoles, and 2H-[1]benzoselenino[4,3,2-cd]indazoles have demonstrated pharmacological activity against a broad spectrum of Gram-positive and Gram-negative bacteria, yeasts, and fungi, as well as activity against the L1210 and P388 murine leukemia cells lines.Pharmaceutical compositions containing the compounds and methods of employing the compounds in methods of treating bacterial or fungal infections and of inhibiting the growth of neoplasms in mammals are also disclosed.
    Type: Grant
    Filed: May 24, 1985
    Date of Patent: August 5, 1986
    Assignee: Warner-Lambert Company
    Inventors: Edward F. Elslager, Leslie M. Werbel, Daniel F. Ortwine, Donald F. Worth, Howard D. H. Showalter, David B. Capps, Ellen M. Berman, Vlad E. Gregor, Anthony D. Sercel