Abstract: A chip-based optical detection system for detecting a target component in a liquid sample is provided. The system comprises a fluid pathway disposed in an interior volume of the chip; an inlet fluidically connecting an external surface of the chip to the fluid pathway; an optical element at least partially defining the fluid pathway; and a flow controller configured to control a flow of the liquid sample through the fluid pathway. One or more capture components are immobilised on the optical element, one or more detection reagents are provided in a proximity of the capture components, and the flow controller is configured to control the flow of the liquid sample along the fluid pathway such that the detection reagents are brought into contact with the capture components via diffusion.

Abstract: An assay cartridge for detecting a target component in a liquid sample is provided. The cartridge comprises: a sample collection unit configured to introduce the liquid sample into the cartridge; a fluid pathway commencing at its proximal end at the sample collection unit and extending distally through the cartridge including: one or more capture components immobilised within the fluid pathway; one or more detection reagents provided within the diffusion distance of the capture components.

Abstract: An assay cartridge for detecting a target component in a liquid sample is provided. The cartridge comprises: a sample collection unit configured to introduce the liquid sample into the cartridge; a fluid pathway commencing at its proximal end at the sample collection unit and extending distally through the cartridge including: one or more capture components immobilised within the fluid pathway; one or more detection reagents provided proximally of or level with the capture components each contained within a liquid droplet.