Patents by Inventor Vladi{acute over (m)}ir Oremus

Vladi{acute over (m)}ir Oremus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,3-disubstituted ureas as ACAT inhibitors, and method of preparing thereof
    Patent number: 6444691
    Abstract: The invention relates to 1,3-disubstituted ureas of general formula (I) where R1 is an aryl, R2 is nitro and/or amino, and X is oxygen and/or sulfur, and the method of preparing thereof which consists in treating aromatic amines with isocyanates. Isocyanates may be formed in situ and the reaction carried out in toluene, at 80° C. If the nitro group is formed, it is reduced with hydrogen in the presence of palladium catalyst to the amino group. The obtained 1,3-disubstituted ureas are inhibitors of the activity of the acyl co-enzyme A: cholesterol acyltransferase (ACAT) enzyme, and may be used to inhibit cholesterol esterification and absorption in hypercholesterolemia.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: September 3, 2002
    Assignee: Solvakofarma, a.s.
    Inventors: Vladi{acute over (m)}ir Oremus, Vendelín {haeck over (S)}mahovský, Viera Fáberová, Ivan Kakalík, {haeck over (L)}udmila Schmidtová, Marián Zemánek