Patents by Inventor Vladimir A. Kuksa

Vladimir A. Kuksa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the treatment of diabetic retinopathy and other ophthalmic diseases
    Patent number: 11795136
    Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: October 24, 2023
    Assignee: ACUCELA INC.
    Inventors: Claes Olof Bavik, Susan Hayes Henry, Ryo Kubota, Vladimir A. Kuksa
  • Inhibitors of VAP-1
    Patent number: 11787791
    Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: October 17, 2023
    Assignee: ACUCELA INC.
    Inventors: Mark W. Orme, Edison S. Zuniga, Vladimir A. Kuksa, Russell Stuart Craft, Eduardo Moreno Saveedra, Johannes Wilhelm Georg Meissner, Jacobus Antonius Joseph den Hartog, Albert Cornelis Dros
  • INHIBITORS OF VAP-1
    Publication number: 20230295140
    Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
    Type: Application
    Filed: May 24, 2023
    Publication date: September 21, 2023
    Inventors: Mark W. ORME, Edison S. ZUNIGA, Vladimir A. KUKSA, Russell Stuart CRAFT, Eduardo Moreno SAVEEDRA, Johannes Wilhelm Georg MEISSNER, Jacobus Antonius Joseph den HARTOG, Albert Cornelis DROS
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20230218549
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt’s Disease.
    Type: Application
    Filed: August 5, 2022
    Publication date: July 13, 2023
    Inventors: Ian L. SCOTT, Vladimir A. KUKSA, Mark W. ORME, Thomas L. LITTLE, JR., Anna GALL, Feng HONG
  • Alkoxy compounds for disease treatment
    Patent number: 11446261
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: September 20, 2022
    Assignee: Acucela Inc.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • INHIBITORS OF VAP-1
    Publication number: 20220024915
    Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
    Type: Application
    Filed: September 27, 2019
    Publication date: January 27, 2022
    Inventors: Mark W. ORME, Edison S. ZUNIGA, Vladimir A. KUKSA, Russell Stuart CRAFT, Eduardo Moreno SAVEEDRA, Johannes Wilhelm Georg MEISSNER, Jacobus Antonius Joseph den HARTOG, Albert Cornelis DROS
  • INHIBITORS OF VAP-1
    Publication number: 20210387975
    Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
    Type: Application
    Filed: September 27, 2019
    Publication date: December 16, 2021
    Inventors: Mark W. ORME, Edison S. ZUNIGA, Vladimir A. KUKSA, Russell Stuart CRAFT, Eduardo Moreno SAVEEDRA, Johannes Wilhelm Georg MEISSNER, Jacobus Antonius Joseph den HARTOG, Albert Cornelis DROS
  • Methods for the Treatment of Diabetic Retinopathy and other Ophthalmic Diseases
    Publication number: 20210171435
    Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
    Type: Application
    Filed: July 21, 2020
    Publication date: June 10, 2021
    Inventors: Claes Olof BAVIK, Susan Hayes HENRY, Ryo KUBOTA, Vladimir A. KUKSA
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20210077427
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: May 1, 2020
    Publication date: March 18, 2021
    Inventors: Ian L. SCOTT, Vladimir A. KUKSA, Mark W. ORME, Thomas L. LITTLE, Jr., Anna GALL, Feng HONG
  • Methods for the treatment of diabetic retinopathy and other ophthalmic diseases
    Patent number: 10730825
    Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: August 4, 2020
    Assignee: ACUCELA INC.
    Inventors: Claes Olof Bavik, Susan Hayes Henry, Ryo Kubota, Vladimir A. Kuksa
  • Alkoxy compounds for disease treatment
    Patent number: 10639286
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: May 5, 2020
    Assignee: ACUCELA INC.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20190183816
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: July 23, 2018
    Publication date: June 20, 2019
    Inventors: Ian L. SCOTT, Vladimir A. KUKSA, Mark W. ORME, Thomas L. LITTLE, JR., Anna GALL, Feng HONG
  • Alkoxy compounds for disease treatment
    Patent number: 10188615
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: January 29, 2019
    Assignee: ACUCELA INC.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • Methods for the Treatment of Diabetic Retinopathy and other Ophthalmic Diseases
    Publication number: 20180346407
    Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
    Type: Application
    Filed: April 30, 2018
    Publication date: December 6, 2018
    Inventors: Claes Olof BAVIK, Susan Hayes HENRY, Ryo KUBOTA, Vladimir A. KUKSA
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20180177746
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: August 8, 2017
    Publication date: June 28, 2018
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • Methods for the treatment of diabetic retinopathy and other ophthalmic diseases
    Patent number: 9957224
    Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: May 1, 2018
    Assignee: ACUCELA INC
    Inventors: Claes Olof Bavik, Susan Hayes Henry, Ryo Kubota, Vladimir A. Kuksa
  • Stabilized mutant opsin proteins
    Patent number: 9907762
    Abstract: Methods and compositions for stabilizing opsin protein, such as a Pro23His mutant opsin protein, in a vertebrate visual system, by administration of opsin-binding synthetic retinoids, are provided. The mutant opsin protein binds to the synthetic retinoid, which stabilizes the mutant opsin protein and/or ameliorates the effects of the mutant opsin protein on the vertebrate visual system.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: March 6, 2018
    Assignees: UNIVERSITY OF WASHINGTON, REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Krzysztof Palczewski, Shalesh Kaushal, Vladimir Kuksa, Syed M. Noorwez
  • Alkoxy compounds for disease treatment
    Patent number: 9737496
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: August 22, 2017
    Assignee: ACUCELA INC.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20170049722
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: September 8, 2016
    Publication date: February 23, 2017
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, JR., Anna Gall, Feng Hong
  • SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS
    Publication number: 20170022180
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: September 10, 2015
    Publication date: January 26, 2017
    Inventors: Vladimir A. Kuksa, Mark W. Orme, Feng Hong, Ryo Kubota