Patents by Inventor Vladimir Baranov
Vladimir Baranov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220288246Abstract: A new class of mass-tag polymers is provided, which include enriched metal isotopes such as zirconium and hafnium mass tags. The chemistry of these new mass tags are different from that of lanthanide mass tags, and opens up new mass channels that can be used in mass cytometry. These polymers may be used for mass cytometry, therapeutic delivery of a radioactive isotope, or screening of a therapeutic isotope. Aspects include a kit, method of making, and method of using a polymer, isotopic composition, or both. A kit may include a polymer. The polymer may include pendant groups that chelate an enriched isotope, such as zirconium and/or hafnium. The kit may include an isotopic composition comprising an enriched zirconium or hafnium isotope. Polymers may be conjugated to a biologically active material. Aspects may also include making a kit. Aspects include use of a kit, such as for mass cytometry.Type: ApplicationFiled: August 7, 2020Publication date: September 15, 2022Applicants: Fluidigm Canada Inc., THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Peng Liu, Daniel Majonis, Vladimir Baranov, Mitchel A. Winnik, Hyungjun Cho
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Publication number: 20220155308Abstract: A lyophilized antibody panel is disclosed for interrogation using elemental analysis. The antibody panel includes multiple antibodies each element-tagged or element-labelled with one or more isotopes such that each different antibody is isotopically distinguishable from the other antibodies. Each element tag can include one or more unique isotopes or unique combinations of isotopes. The set of element-tagged antibodies can be lyophilized in admixture. Thus, the lyophilized element-tagged antibody panel can be easily and efficiently resuspended and mixed with a sample prior to interrogation with an elemental analyzer, such as a mass spectrometer. This lyophilized element-tagged antibody panel can provide the benefits of an element-tagged assay while also being easy to use and remaining stable for long durations.Type: ApplicationFiled: March 27, 2020Publication date: May 19, 2022Applicant: Fluidigm Canada Inc.Inventors: Stephen K.H. Li, Daniel Majonis, Vladimir Baranov, Olga Ornatsky, Bedilu Allo, Dmitry Bandura, Colin Thom, Greg Stelzer, Alexander Loboda
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Patent number: 11220956Abstract: The disclosure relates to a method for detecting belt slip of a belt drive driving a generator of an internal combustion engine, said belt drive having a belt tensioner that can be adjusted in operation and adjusts the pre-tensioning force of the belt according to the detected belt slip. According to said method, the rotational speed profile of the crankshaft is recorded during an angular window of the crankshaft of m·360 degrees and an average value of the crankshaft rotational speed is formed from said rotational speed profile; temporally independently from the recording of the rotational speed profile of the crankshaft, the rotational speed course of the generator shaft is recorded during an angular window of the generator shaft of n·u?1·360 degrees and an average value of the generator shaft rotational speed is formed from said rotational speed profile.Type: GrantFiled: April 10, 2018Date of Patent: January 11, 2022Assignee: Schaeffler Technologies AG & Co. KGInventors: Martin Heckel, Arno Bächstädt, Christian Hoffmann, Massimo Abrate, Vladimir Baranov
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Publication number: 20210356376Abstract: This disclosure relates to reagents and their use for elemental imaging mass spectrometry of biological samples.Type: ApplicationFiled: September 9, 2019Publication date: November 18, 2021Applicants: Fluidigm Canada Inc., The Governing Council of the University of TorontoInventors: Taunia Closson, Vladimir Baranov, Mitchell A. Winnik
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Publication number: 20210239707Abstract: Embodiments of the present invention relate to reagents and their use for elemental imaging mass spectrometry of biological samples. The embodiments comprising methods for quantifying one or more analytes within a sample, comprising the steps of: (a) providing the sample, wherein the one or more analytes are immobilized to a sample carrier, wherein the sample has been labelled with one or more mass tags comprising one or more labelling atoms, (b) performing mass cytometry on the sample to determine the level of the one or more labelling atoms, wherein the level of the one or more labelling atoms corresponds to the copy number of the one or more analytes.Type: ApplicationFiled: April 26, 2019Publication date: August 5, 2021Applicant: Fluidigm Canada Inc.Inventors: Alexander V. Loboda, Olga Ornatsky, Vladimir Baranov, Nikita Zabinyakov, Anastasia Mavropoulos, Daniel Majonis, Bedilu Allo, Taunia Closson
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Publication number: 20200362062Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: May 5, 2020Publication date: November 19, 2020Inventors: MITCHELL A. WINNIK, MARK NITZ, VLADIMIR BARANOV, XUDONG LOU
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Patent number: 10752707Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: July 9, 2019Date of Patent: August 25, 2020Assignee: FLUIDIGM CANADA INC.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
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Patent number: 10669358Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: July 27, 2018Date of Patent: June 2, 2020Assignee: FLUIDIGM CANADA INC.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
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Publication number: 20200056536Abstract: The disclosure relates to a method for detecting belt slip of a belt drive driving a generator of an internal combustion engine, said belt drive having a belt tensioner that can be adjusted in operation and adjusts the pre-tensioning force of the belt according to the detected belt slip. According to said method, the rotational speed profile of the crankshaft is recorded during an angular window of the crankshaft of m·360 degrees and an average value of the crankshaft rotational speed is formed from said rotational speed profile; temporally independently from the recording of the rotational speed profile of the crankshaft, the rotational speed course of the generator shaft is recorded during an angular window of the generator shaft of n·u?1·360 degrees and an average value of the generator shaft rotational speed is formed from said rotational speed profile.Type: ApplicationFiled: April 10, 2018Publication date: February 20, 2020Applicant: Schaeffler Technologies AG & Co. KGInventors: Martin Heckel, Arno Bächstädt, Christian Hoffmann, Massimo Abrate, Vladimir Baranov
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Publication number: 20190353576Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.Type: ApplicationFiled: June 5, 2019Publication date: November 21, 2019Inventor: Vladimir Baranov
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Publication number: 20190345272Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: July 9, 2019Publication date: November 14, 2019Inventors: MITCHELL A. WINNIK, MARK NITZ, VLADIMIR BARANOV, XUDONG LOU
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Publication number: 20190317082Abstract: Analyzing samples injected into an inductively coupled plasma source can be improved by one or more of a stabilizing solution mixable with a sample prior to injection and a heated injector. The stabilizing solution can minimize the difference in osmotic pressure between the solution and the cells with a relatively low amount of dissolved solids (e.g., at or below about 0.2%). The stabilizing solution can contain a salt (e.g., ammonium nitrate) present in concentrations of at least 5 mM. The injector can be heated before and/or during injection. In some cases, heat from adjacent parts can be channeled into the injector to improve heating of the injector. An injector heated to sufficient temperatures can minimize solute buildup and can extend the usable time between cleanings. These improvements can be especially useful in elemental analysis, such as inductively coupled plasma mass spectrometry or inductively coupled plasma optical emission spectrometry.Type: ApplicationFiled: April 12, 2019Publication date: October 17, 2019Applicant: Fluidigm Canada Inc.Inventors: Vladimir Baranov, Alexander Loboda, Michael Sullivan
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Publication number: 20190094121Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.Type: ApplicationFiled: September 20, 2018Publication date: March 28, 2019Inventor: Vladimir Baranov
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Publication number: 20190077890Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: July 27, 2018Publication date: March 14, 2019Applicant: FLUIDIGM CANADA INC.Inventors: MITCHELL A. WINNIK, MARK NITZ, VLADIMIR BARANOV, XUDONG LOU
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Patent number: 10107734Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.Type: GrantFiled: August 8, 2016Date of Patent: October 23, 2018Assignee: Fluidigm Canada Inc.Inventor: Vladimir Baranov
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Patent number: 10072104Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: October 5, 2015Date of Patent: September 11, 2018Assignee: Fluidigm Canada Inc.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
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Patent number: 9915198Abstract: A belt pulley arrangement for a belt drive to drive auxiliary units of a motor vehicle, having a belt pulley for introducing a torque that can be provided via a flexible drive means, an output shaft for driving an auxiliary unit, in particular a cooling water pump, and an electric machine for the transmission of torque between the belt pulley and the output shaft, wherein the electric machine has a rotor connected to the belt pulley and a stator connected to the output shaft. As a result of the power flow between the belt pulley and the output shaft, which can be influenced by the electric machine, it is not necessary to design the auxiliary unit that is attached via the output shaft for the least beneficial operating point, so that the auxiliary unit can be dimensioned smaller and a reduction in the installation space for motor vehicle components, in particular the installation space for auxiliary units of a motor vehicle that can be driven via the belt drive, is made possible.Type: GrantFiled: August 5, 2013Date of Patent: March 13, 2018Assignee: Schaeffler Technologies AG & Co., KGInventors: Oliver Dippold, Vladimir Baranov, Ralf Wagner, Bernd Hartmann, Laszlo Man
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Publication number: 20170089821Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.Type: ApplicationFiled: August 8, 2016Publication date: March 30, 2017Inventor: Vladimir Baranov
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Patent number: 9435787Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.Type: GrantFiled: January 20, 2016Date of Patent: September 6, 2016Assignee: Fluidigm Canada Inc.Inventor: Vladimir Baranov
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Publication number: 20160131635Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.Type: ApplicationFiled: January 20, 2016Publication date: May 12, 2016Inventor: Vladimir Baranov