Patents by Inventor Vladimir Berezin

Vladimir Berezin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100040623
    Abstract: The present invention relates to peptide fragments derived from proteins of the S-100 family promoting neural cell survival, differentiation and proliferation. The invention further relates to pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.
    Type: Application
    Filed: December 20, 2006
    Publication date: February 18, 2010
    Inventors: Elisabeth Bock, Vladimir Berezin, Darya Kiryushko
  • Publication number: 20090305951
    Abstract: The present invention relates to a compound comprising the third Immunoglobulin (Ig3) module, and/or the fourth Immunoglobulin (Ig4) module, and/or the fifth immunoglobulin (Ig5) module, and/or the first Fibronectin III (Fn3,1) module, and/or the second Fibronectin III (Fn3,2) module of neural cell adhesion molecule (NCAM), or a fragment, or a variant thereof, capable of interacting with an Fibroblast Growth Factor (FGF) receptor and/or Adenosine-Tri-Phosphate (ATP) and/or L1, and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to a pharmaceutical composition comprising said compound, a process of producing a pharmaceutical composition and the use of said compound.
    Type: Application
    Filed: May 4, 2009
    Publication date: December 10, 2009
    Inventors: Vladislav V. Kiselyov, Galina Skladchikova, Vladimir Berezin, Elisabeth Bock
  • Publication number: 20090221506
    Abstract: The present invention relates to peptide fragments derived from the proteins belonging to the TGFbeta superfamily, pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory and/or inhibiting inflammatory response are beneficial for treatment.
    Type: Application
    Filed: August 15, 2006
    Publication date: September 3, 2009
    Applicant: Copenhagen University
    Inventors: Elisabeth Bock, Vladimir Berezin
  • Publication number: 20090202554
    Abstract: The present invention relates to a method for modulating the interaction between at least two proteins, wherein at least one of the two proteins is a functional cell-surface receptor and the other protein is the receptor ligand. The invention features a binding site of said functional cell-surface receptor on the receptor ligand and discloses a series of amino acid sequences, which are part of the structure of said binding site and/or involved in the interaction between the receptor and the ligand. Moreover, the present invention features methods for molecular design and screening of a candidate compound capable of modulating the interaction between the functional cell-surface receptor and receptor ligand through the described binding site, and provides a screening assay for identification of such a compound.
    Type: Application
    Filed: February 12, 2009
    Publication date: August 13, 2009
    Applicant: ENKAM PHARMACEUTICALS A/S
    Inventors: VLADIMIR BEREZIN, ELISABETH BOCK, MORTEN ALBRECHTSEN
  • Publication number: 20090197801
    Abstract: The present invention relates to peptide compounds that are capable of stimulating neuronal differentiation, neurite outgrowth and survival of neural cells, and enhancing synaptic plasticity, learning and memory, methods of treating diseases and conditions of nervous system by administration of compositions comprising said compounds. The compounds and compositions of the invention include peptide sequences that are derived from the sequence of human erythropoietin or proteins that are homologous of human erythropoietin.
    Type: Application
    Filed: May 8, 2006
    Publication date: August 6, 2009
    Inventors: Vladimir Berezin, Elisabeth Bock
  • Publication number: 20090105149
    Abstract: The present invention relates to new peptide compounds capable of binding to fibroblast growth factor receptor (FGFR), said compounds comprising two individual amino acid sequences, wherein at least one of the two amino acid sequences is capable of binding to FGFR. The invention discloses the amino acid sequences of the compounds and features pharmaceutical compositions comprising thereof. Invention also relates to uses of the compounds and pharmaceutical compositions comprising thereof for the treatment or prevention of different pathological conditions, wherein FGFR plays a role in pathology and/or recovery from the disease. New peptide compounds of the invention are obtainable by the ligand presenting assembly (LPA) method.
    Type: Application
    Filed: August 6, 2004
    Publication date: April 23, 2009
    Applicant: ENKAM PHARMACEUTICALS A/S
    Inventors: Morten Albrechtsen, Elisabeth Bock, Vladimir Berezin, Arne Valdemar Holm
  • Publication number: 20090092617
    Abstract: The invention relates to new peptide compounds capable of modulating cell proliferation, differentiation, survival and/or motility. The peptide compounds of the invention comprise short peptide fragments of the ErbB receptor and are capable of binding to ErbB and modulating activity of the receptor. The invention also relates to antibodies capable of binding to an epitope comprising a peptide sequence of the invention, pharmaceutical compositions comprising the peptide sequences and/or antibodies and uses thereof for treatment of conditions wherein modulating activity of ErbB is needed.
    Type: Application
    Filed: April 3, 2007
    Publication date: April 9, 2009
    Inventors: Elisabeth Bock, Vladimir Berezin, Gro Klitgaard Povlsen
  • Publication number: 20090074774
    Abstract: The present invention relates to new peptide compounds capable of direct binding to fibroblast growth factor receptor (FGFR) and activating said receptor. The compounds of the invention comprise peptide fragments of the neural cell adhesion molecule (NCAM) derived from the fibronectin type-III module 1 (F3, 1) of NCAM. Peptide sequences of the invention are capable of stimulating learning and memory and/or neurite outgrowth and/or neural cell survival. Peptide sequences and compounds comprising thereof, according to the invention, may be beneficially used for treatment and/or prevention of different pathological conditions wherein FGFR and/or NCAM play a role in pathology and/or recovery from disease. Accordingly, pharmaceutical compositions comprising the peptide sequences and compounds of the invention are also in the scope of protection.
    Type: Application
    Filed: June 17, 2005
    Publication date: March 19, 2009
    Inventors: Elisabeth Bock, Vladimir Berezin
  • Publication number: 20090074779
    Abstract: The present invention relates to peptide sequences capable of stimulating neuronal cell differentiation, neural cell survival and neuronal plasticity associated with memory and learning. The peptide sequences of the invention are derived from the proteins belonging to neurotrophic factors, such as NGF, NT3, NT4/5 and BDNF. The invention also relates to pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory are beneficial for treatment.
    Type: Application
    Filed: November 7, 2006
    Publication date: March 19, 2009
    Applicant: Copenhagen University
    Inventors: Elisabeth Bock, Vladimir Berezin
  • Publication number: 20080249004
    Abstract: The present invention relates to a method of modulating differentiation, adhesion and/or survival of the neural cell adhesion molecule (NCAM) presenting cells by providing compounds capable of modulating the interaction between the Ig1, Ig2 and/or Ig3 modules of NCAM. The invention provides candidate compounds capable of modulating the interaction between the Ig1, Ig2 and/or Ig3 modules of NCAM by using methods for screening and testing described in the application. The invention further relates to pharmaceutical compositions comprising compounds capable of modulating the interaction between the Ig1, Ig2 and/or Ig3 modules of NCAM and to use of the pharmaceutical compositions and compounds for the modulation of differentiation, adhesion and/or survival of NCAM presenting cells.
    Type: Application
    Filed: September 29, 2004
    Publication date: October 9, 2008
    Applicant: ENKAM Pharmaceuticals A/S
    Inventors: Elisabeth Bock, Vladimir Berezin, Vladyslav Soroka
  • Publication number: 20080226639
    Abstract: The invention relates to new peptide fragments capable of stimulating neurite outgrowth, stimulating of cell survival, stimulating neural plasticity associated with memory and learning, and modulating cell motility. The biological activity of the peptide fragments is associated with their capability of binding and activating a neurotrophin receptor of the Trk family. The peptide fragments of the invention comprise an amino acid motif which is essential for binding and activating a neurotrophin receptor of the Trk family. The invention also concerns pharmaceutical compositions comprising the compounds and uses thereof for prevention and/or treatment of conditions and/or diseases, wherein neurotrophing, Tkr receptors and/or NCAM play an important role, and wherein stimulating of neurite outgrowth, cell survival, neural plasticity associated with memory and learning, and/or modulating cell motility is beneficial for treatment.
    Type: Application
    Filed: June 10, 2005
    Publication date: September 18, 2008
    Applicant: Enkan Pharmaceuticals A/S
    Inventors: Elisabeth Bock, Vladimir Berezin
  • Publication number: 20080225150
    Abstract: A new kind of pixel is formed of two floating diffusions of different sizes and different conductivity type. The two floating diffusions have different image characteristics, and hence form a knee-shaped slope.
    Type: Application
    Filed: April 18, 2008
    Publication date: September 18, 2008
    Inventors: Vladimir Berezin, Eric R. Fossum
  • Patent number: 7402560
    Abstract: The invention provides novel compounds which are capable of stimulating the proliferation or/and the outgrowth from cells presenting the neural cell adhesion molecule (NCAM). Additionally, the invention relates to methods for treatment of normal, degenerated and damaged NCAM presenting cells.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: July 22, 2008
    Inventors: Lars Christian Ronn, Arne Holm, Marianne Olsen, Soren Ostergaard, Peter H. Jensen, Flemming M. Poulsen, Vladislav Soroka, Igor Ralets, Vladimir Berezin, Elisabeth Bock
  • Patent number: 7372490
    Abstract: A new kind of pixel is formed of two floating diffusions of different sizes and different conductivity type. The two floating diffusions have different image characteristics, and hence form a knee-shaped slope.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: May 13, 2008
    Assignee: Micron Technology, Inc.
    Inventors: Vladimir Berezin, Eric R. Fossum
  • Patent number: 7279670
    Abstract: A CMOS image sensor obtains color through the use of two or three superposed layers. Each pixel in the image sensor includes a plurality of superposed photosensitive p-n junctions with individual charge integration regions. The combination of each of the superposed layers provides increased sensitivity and resolution of a single chip color imager.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: October 9, 2007
    Assignee: Micron Technology, Inc.
    Inventor: Vladimir Berezin
  • Patent number: 7244646
    Abstract: A CMOS imager with two adjacent pixel active area regions without the presence of an intervening trench isolation region that typically separates two adjacent pixels and their associated photodiodes is provided. The shared active area region isolates the two adjacent photodiodes and provides good substrate to surface pinned layer contact without the presence of n? type dopant ions and due to the presence of p-type dopant ions. As a result, the size of the imager can be reduced and the photodiodes of the two adjacent pixels have increased capacitance.
    Type: Grant
    Filed: March 23, 2005
    Date of Patent: July 17, 2007
    Assignee: Micron Technology, Inc.
    Inventors: Inna Patrick, Vladimir Berezin
  • Patent number: 7230645
    Abstract: A method of operating a CMOS imager is presented wherein a reset transistor source/drain of a first pixel is biased with a first voltage source, a source follower transistor of a second pixel is biased with the same first voltage source, a reset transistor source/drain of the second pixel is biased with a second voltage source, and the first voltage source is dropped to ground during a reset of the second pixel.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: June 12, 2007
    Assignee: Micron Technology, Inc.
    Inventors: Vladimir Berezin, Alexander Krymski
  • Publication number: 20070116702
    Abstract: The present invention relates to compounds capable of stimulating survival of cells presenting the neural cell adhesion molecule (NCAM) or an NCAM-ligand (counter-receptor), such as neurons. Further, the present invention relates to the use of pharmaceutical compositions and medicaments in the treatment or protection of cells presenting NCAM or NCAM ligands. More particularly the invention describes the use of a compound comprising a peptide comprising at least 5 contiguous amino acid residues from an amino acid sequence of NCAM, a fragment thereof, or a variant thereof or a mimic thereof, for the preparation of a medicament for preventing cell death of cells presenting said NCAM or an NCAM ligand.
    Type: Application
    Filed: December 13, 2006
    Publication date: May 24, 2007
    Inventors: Vladimir Berezin, Elisabeth Bock, Lene Kohler
  • Publication number: 20070024727
    Abstract: An active pixel sensor includes mixed analog and digital signal integration on the same substrate. The analog part of the array forms the active pixel sensor, and the digital part of the array does digital integration of the signal.
    Type: Application
    Filed: September 29, 2006
    Publication date: February 1, 2007
    Inventor: Vladimir Berezin
  • Publication number: 20060281130
    Abstract: The present invention relates to a method for modulating the interaction between at least two proteins, wherein at least one of the two proteins is a functional cell-surface receptor and the other protein is the receptor ligand. The invention features a binding site of said functional cell-surface receptor on the receptor ligand and discloses a series of amino acid sequences, which are part of the structure of said binding site and/or involved in the interaction between the receptor and the ligand. Moreover, the present invention features methods for molecular design and screening of a candidate compound capable of modulating the interaction between the functional cell-surface receptor and receptor ligand through the described binding site, and provides a screening assay for identification of such a compound.
    Type: Application
    Filed: December 18, 2003
    Publication date: December 14, 2006
    Inventors: Elisabeth Bock, Vladimir Berezin, Morten Albrechtsen