Patents by Inventor Vladimir Bogin

Vladimir Bogin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10869916
    Abstract: Disclosed are methods, compositions of matter, and protocols useful for the induction of a therapeutic immune modulatory response through administration of exosomes derived from a stem cell source. In one embodiment, said stem cell source is endometrial regenerative cells. Specifically, in one embodiment stem cell derived exosomes are used as a method of treating an autoimmune condition such as rheumatoid arthritis, multiple sclerosis, or systemic lupus erythromatosis.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: December 22, 2020
    Assignee: XON Cells, Inc.
    Inventors: Thomas Ichim, Vladimir Bogin
  • Publication number: 20180369351
    Abstract: Disclosed are methods, compositions of matter, and protocols useful for the induction of a therapeutic immune modulatory response through administration of exosomes derived from a stem cell source. In one embodiment, said stem cell source is endometrial regenerative cells. Specifically, in one embodiment stem cell derived exosomes are used as a method of treating an autoimmune condition such as rheumatoid arthritis, multiple sclerosis, or systemic lupus erythromatosis.
    Type: Application
    Filed: June 22, 2018
    Publication date: December 27, 2018
    Applicant: XON Cells, Inc.
    Inventors: Thomas ICHIM, Vladimir BOGIN
  • Publication number: 20170100438
    Abstract: Disclosed are compositions of matter, therapeutic protocols, and immunization means to induce an active immune response to vasculature feeding glioma or other brain neoplasia. In one embodiment the invention provides administration of placental derived endothelial cells at concentrations of 10 million to 50 million administered in a manner to stimulate immunity toward blood vessels supplying glioma or other brain neoplastic malignancies. The invention provides means of blocking augmenting efficacy of immunotherapy, chemotherapy, and radiotherapy.
    Type: Application
    Filed: October 7, 2016
    Publication date: April 13, 2017
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Santosh Kesari, Vladimir Bogin
  • Publication number: 20170095545
    Abstract: Disclosed are compositions of matter, methods, and protocols useful for treatment of cancer through induction of anti-angiogenic immune responses by vaccination together with immune modulation triggered by checkpoint inhibitors. The invention provides placenta, placental endothelial, placental fibroblasts, and mixtures thereof as immunogens, whose anti-angiogenic activity is augmented by utilization of checkpoint inhibitors. Means of differentiating tumor cells directly into endothelial or endothelial-like cells and utilizing said cells as immunogens for the purpose of inducing immunity against blood vessels feeding tumors. In one embodiment CTLA4 blockade is performed in combination with an immunogen capable of triggering immunity towards tumor endothelial cells. In another embodiment blockade of the PD1-PD1 ligand pathway is performed in combination with induction of anti-angiogenic immune response.
    Type: Application
    Filed: May 7, 2016
    Publication date: April 6, 2017
    Applicant: Batu Biologics, Inc.
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Vladimir Bogin
  • Publication number: 20170021002
    Abstract: Disclosed are protocols, procedures and therapeutic compositions useful for augmentation of immunity to cancer and cancer associated endothelial cells by treatment with histone deacetylase (HDAC) inhibitors capable of augmenting stimulatory and costimulatory molecules on said cancer vaccines. Additionally, the invention teaches specific concentrations of HDAC inhibitors useful for stimulation of in vivo immunity to tumor and tumor endothelial cell targeting vaccines.
    Type: Application
    Filed: May 18, 2016
    Publication date: January 26, 2017
    Applicant: Batu Biologics, Inc.
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Vladimir Bogin, Boris Minev
  • Publication number: 20160361399
    Abstract: Disclosed are methods, compositions of matter, and protocols useful for the induction of a therapeutic immune modulatory response through administration of exosomes derived from a stem cell source. In one embodiment, said stem cell source is endometrial regenerative cells. Specifically, in one embodiment stem cell derived exosomes are used as a method of treating an autoimmune condition such as rheumatoid arthritis, multiple sclerosis, or systemic lupus erythromatosis.
    Type: Application
    Filed: August 4, 2016
    Publication date: December 15, 2016
    Applicant: XON Cells, Inc.
    Inventors: Thomas ICHIM, Vladimir BOGIN
  • Publication number: 20160340650
    Abstract: Neutrophil extracellular traps (NETS) are webs of DNA held together with immunogenic peptides, released by neutrophils subsequent to activation. NETS are the most potent stimulator of dendritic cells, monocytes and T cells given their ability to activate TLR3, TLR4, TLR7 and TLR9. The use of NETS for in vivo stimulation of immunity in a therapeutic sense has not been utilized due to fear of anti-DNA antibody formation and subsequent development of systemic lupus erythromatosis. The current invention provides means of safely generating NETS in vitro through peripheral blood utilizing clinically safe means such as yeast-derived component zymosan, isolating said NETS, utilizing said NETS to in vitro activate cytokine production from PBMC in vitro, and concentrating said cytokines. Cytokines generated by this methodology have superior ability to stimulate NK cells in vitro as compared to isolated NK stimulatory cytokines.
    Type: Application
    Filed: May 23, 2016
    Publication date: November 24, 2016
    Applicant: Batu Biologics, Inc.
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Vladimir Bogin
  • Patent number: 9427450
    Abstract: Disclosed are methods, compositions of matter, and protocols useful for the induction of a therapeutic immune modulatory response through administration of exosomes derived from a stem cell source. In one embodiment, said stem cell source is endometrial regenerative cells. Specifically, in one embodiment stem cell derived exosomes are used as a method of treating an autoimmune condition such as rheumatoid arthritis, multiple sclerosis, or systemic lupus erythromatosis.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: August 30, 2016
    Assignee: XON Cells, Inc.
    Inventors: Thomas Ichim, Vladimir Bogin
  • Publication number: 20150331998
    Abstract: Methods and apparatus, including computer program products, for a medical information access portal. A system includes a provider server including an electronic medical record (EMR) database, a hospital server including a hospital information system database, and a host server including a medical information access portal, the medical information access portal configured to exchange patient data between the EMR database of the provider server and the hospital information system database of the hospital server.
    Type: Application
    Filed: May 18, 2015
    Publication date: November 19, 2015
    Inventors: Nathan Rozenfeld, Vladimir Bogin
  • Publication number: 20130273011
    Abstract: Disclosed are stem cells and nanoparticles derived from said stem cells, useful for the treatment of acute radiation syndrome (ARS) and other inflammatory conditions. In one embodiment, Endometrial Regenerative Cells (ERC) are administered to patients having been exposed to radiation to augment recovery of endogenous hematopoietic stem cells. In another embodiment, exosomes, nanoparticles that are generated by various stem cells are used as a drug for treatment of inflammatory conditions.
    Type: Application
    Filed: April 17, 2013
    Publication date: October 17, 2013
    Applicant: Medistem, Inc.
    Inventors: Thomas Ichim, Vladimir Bogin, Amit Patel