Patents by Inventor Vladimir Brusic

Vladimir Brusic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of conserved peptide blocks in homologous polypeptides
    Patent number: 9205144
    Abstract: Methods for identifying at least one conserved peptide block in three or more homologous polypeptides are provided and compositions comprising conserved peptides are provided. More particularly, methods for selecting conserved peptides in variable viral polypeptides for use in immunogenic compositions are provided.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: December 8, 2015
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Vladimir Brusic, Lars Ronn Olsen, Ellis L. Reinherz, Guanglan Zhang, Christian Simon
  • Oligonucleotide array for tissue typing
    Patent number: 8969254
    Abstract: Oligonucleotide-based microarrays for tissue typing (e.g., HLA tissue typing) are provided. More particularly, the microarrays are high resolution arrays useful for diagnostic evaluations and determining donor/recipient transplant compatibility.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: March 3, 2015
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Ellis L. Reinherz, Vladimir Brusic, Guanglan Zhang, Derin Benerci Keskin, David Deluca, Honghuang Lin
  • Identification of conserved peptide blocks in homologous polypeptides
    Publication number: 20130064843
    Abstract: Methods for identifying at least one conserved peptide block in three or more homologous polypeptides are provided and compositions comprising conserved peptides are provided. More particularly, methods for selecting conserved peptides in variable viral polypeptides for use in immunogenic compositions are provided.
    Type: Application
    Filed: June 4, 2012
    Publication date: March 14, 2013
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Vladimir Brusic, Lars Ronn Olsen, Ellis L. Reinherz, Guanglan Zhang, Christian Simon
  • Oligonucleotide Array For Tissue Typing
    Publication number: 20120264627
    Abstract: Oligonucleotide-based microarrays for tissue typing (e.g., HLA tissue typing) are provided. More particularly, the microarrays are high resolution arrays useful for diagnostic evaluations and determining donor/recipient transplant compatibility.
    Type: Application
    Filed: December 16, 2011
    Publication date: October 18, 2012
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Ellis L. Reinherz, Vladimir Brusic, Guanglan Zhang, Derin Benerci Keskin, David Deluca, Honghuang Lin
  • System and method for systematic prediction of ligand/receptor activity
    Publication number: 20050074809
    Abstract: Disclosed is a general system and method, for prediction of binding of peptide-like ligands (peptides) to peptide-like receptors (receptors). Specifically this invention uses non-linear prediction models (including, but not limited to, artificial neural networks), sequence data form ligands and their respective receptors, and known ligand-receptor binding affinities. The representation of ligand-receptor interaction used along with the binding affinity of said interaction is used to train a determining means in a form of a predictive model. Prediction of binding affinity of a novel (not used for training of a predictive model) ligand-receptor interaction, involving a peptide and a particular receptor, involves the combining of representations of both peptide and receptor and presenting that representation to a previously trained predictive model. The system and method can be used as a single predictive model for determination of ligand binding to an individual receptor, or to a group of related receptors.
    Type: Application
    Filed: March 10, 2001
    Publication date: April 7, 2005
    Inventor: Vladimir Brusic