Patents by Inventor Vladimir Coric

Vladimir Coric has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF RILUZOLE PRODRUGS TO TREAT ALZHEIMER'S DISEASE
    Publication number: 20240082340
    Abstract: Disclosed are methods of treating a patient afflicted with Alzheimer's Disease of mild-to-moderate severity by administering to the patient a riluzole prodrug. Pharmaceutical compositions and kits including the riluzole prodrugs are also disclosed.
    Type: Application
    Filed: January 17, 2022
    Publication date: March 14, 2024
    Inventors: Vladimir CORIC, Robert BERMAN
  • USE OF RILUZOLE PRODRUGS TO TREAT ATAXIAS
    Publication number: 20230390252
    Abstract: Disclosed are methods of treating ataxia by administering to a patient in need thereof a riluzole prodrug such as troriluzole. Pharmaceutical compositions and kits including the riluzole prodrugs are also disclosed.
    Type: Application
    Filed: July 17, 2023
    Publication date: December 7, 2023
    Inventors: Vladimir CORIC, Robert BERMAN, Melissa BEINER, Gilbert L'Italien
  • USE OF RILUZOLE PRODRUGS TO TREAT ATAXIAS
    Publication number: 20230355592
    Abstract: Disclosed are methods of treating ataxia by administering to a patient in need thereof a riluzole prodrug such as troriluzole. Pharmaceutical compositions and kits including the riluzole prodrugs are also disclosed.
    Type: Application
    Filed: July 17, 2023
    Publication date: November 9, 2023
    Inventors: Vladimir CORIC, Robert BERMAN, Melissa BEINER, Gilbert L'Italien
  • PREVENTATIVE TREATMENT OF MIGRAINE
    Publication number: 20230321066
    Abstract: Disclosed are methods of for the preventative treatment of migraine, by administering to a patient in need thereof rimegepant or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising rimegepant and kits including the pharmaceutical compositions and instructions are also disclosed.
    Type: Application
    Filed: March 29, 2021
    Publication date: October 12, 2023
    Inventors: Robert CROOP, Vladimir CORIC
  • USE OF RILUZOLE, RILUZOLE PRODRUGS OR RILUZOLE ANALOGS WITH IMMUNOTHERAPIES TO TREAT CANCERS
    Publication number: 20230310595
    Abstract: Disclosed are methods of treating cancer using a combination of an immunotherapeutic agent, such as, for example, a PD-1, PD-L1 or CTLA-4 checkpoint inhibitor, and a glutamate modulating agent such as riluzole or trigriluzole. Pharmaceutical compositions including the immunotherapeutic agents and glutamate modulating agents are also disclosed.
    Type: Application
    Filed: August 1, 2022
    Publication date: October 5, 2023
    Inventor: Vladimir CORIC
  • DUAL TREATMENT OF MIGRAINE
    Publication number: 20230285380
    Abstract: Disclosed is a method of treating migraine in a patient, wherein the method includes administering a CGRP antagonist that is effective for treating acute migraine and prevention of migraine. Also disclosed is a method of prevention of migraine in a patient, wherein the method includes administering a CGRP antagonist that is effective for prevention of migraine and treating acute migraine.
    Type: Application
    Filed: June 11, 2022
    Publication date: September 14, 2023
    Inventors: Vladimir CORIC, Charles M. CONWAY, Robert CROOP, Marianne FROST
  • METHODS OF TREATING PULMONARY INJURY WITH CGRP INHIBITORS
    Publication number: 20230285390
    Abstract: Provided is a method for treating COVID-19 in a patient in need of such treatment, wherein the method includes administration to the patient of a therapeutically effective amount of CGRP inhibitor. Also provided is a pharmaceutical composition for treating COVID-19 in a patient in need of such treatment, wherein the pharmaceutical composition includes a therapeutically effective amount of CGRP inhibitor.
    Type: Application
    Filed: March 22, 2021
    Publication date: September 14, 2023
    Inventors: St John Donnie McGrath, Vladimir CORIC, Charles M. CONWAY, Reese M. Caldwell, Steven M. SCHNITTMAN
  • COMPOSITIONS AND METHODS FOR TREATING OBSESSIVE-COMPULSIVE DISORDER
    Publication number: 20230181541
    Abstract: Disclosed herein is a method for treating obsessive-compulsive disorder in a patient in need thereof by administering to the patient a dosage form including an effective amount of troriluzole.
    Type: Application
    Filed: June 24, 2021
    Publication date: June 15, 2023
    Inventors: Vladimir CORIC, Robert BERMAN, Loren AGUIAR
  • Sublingual formulation of riluzole
    Patent number: 11660267
    Abstract: Disclosed is sublingual administration of riluzole. In particular, a method for treating a neuropsychiatric disorder or symptom by administering a sublingual formulation of riluzole is provided. In addition, a method of relieving or reducing oral pain using the sublingual formulation of riluzole is disclosed.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: May 30, 2023
    Assignee: Biohaven Therapeutics Ltd.
    Inventors: Vladimir Coric, Robert Berman, Ronald S. Vladyka, Amgad Saleh, Danny Yu
  • ORAL FAST-DISPERSING DOSAGE FORM OF RIMEGEPANT
    Publication number: 20230108049
    Abstract: Provided is a fast-dispersing dosage form for oral delivery, wherein the fast-dispersing dosage form includes a rimegepant. Also provided is a method for delivering rimegepant to a subject, wherein the method includes orally administering to the subject a fast-dispersing dosage form including rimegepant.
    Type: Application
    Filed: February 26, 2021
    Publication date: April 6, 2023
    Inventors: Vladimir CORIC, Marianne FROST, Robert CROOP, Charles M. CONWAY
  • Glutamate agents in the treatment of mental disorders
    Patent number: 11554117
    Abstract: Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate modulator to an individual in need thereof. Also provided are methods of enhancing the activity of a serotonin reuptake inhibitor (SRI) comprising co-administering a glutamate modulator and a serotonin reuptake inhibitor. Pharmaceutical composition comprising a serotonin reuptake inhibitor and a glutamate modulator are also provided.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: January 17, 2023
    Assignee: YALE UNIVERSITY
    Inventors: Vladimir Coric, John H. Krystal, Gerard Sanacora
  • INTRANASAL PHARMACEUTICAL COMPOSITIONS OF CGRP INHIBITORS
    Publication number: 20220401439
    Abstract: Provided is pharmaceutical composition for intranasal delivery, wherein the pharmaceutical composition includes a therapeutically active ingredient including a CGRP inhibitor. Also provided is a method for delivering a CGRP inhibitor to a subject, wherein the method includes intranasally administering to the subject a composition including a therapeutically active component including a CGRP inhibitor.
    Type: Application
    Filed: December 17, 2020
    Publication date: December 22, 2022
    Inventors: Vladimir CORIC, Charles M. CONWAY, Robert CROOP, Rajesh KUMAR
  • Use of riluzole, riluzole prodrugs or riluzole analogs with immunotherapies to treat cancers
    Patent number: 11400155
    Abstract: Disclosed are methods of treating cancer using a combination of an immunotherapeutic agent, such as, for example, a PD-1, PD-L1 or CTLA-4 checkpoint inhibitor, and a glutamate modulating agent such as riluzole or trigriluzole. Pharmaceutical compositions including the immunotherapeutic agents and glutamate modulating agents are also disclosed.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: August 2, 2022
    Assignee: Biohaven Therapeutics Ltd.
    Inventor: Vladimir Coric
  • USE OF RILUZOLE ORAL DISINTIGRATING TABLETS FOR TREATING DISEASES
    Publication number: 20220218673
    Abstract: Disclosed are methods of treating a disease in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of riluzole, or a pharmaceutically acceptable salt thereof, in the form of an oral solid molded fast-dispersing dosage form. Pharmaceutical compositions and kits are also disclosed.
    Type: Application
    Filed: May 26, 2019
    Publication date: July 14, 2022
    Inventors: Vladimir Coric, Robert Berman, Irfan Qureshi
  • RIMEGEPANT FOR CGRP RELATED DISORDERS
    Publication number: 20220168295
    Abstract: Disclosed are methods of treating CGRP related disorders, e.g., migraine, by administering to a patient in need thereof rimegepant or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising rimegepant and kits including the pharmaceutical compositions and instructions are also disclosed.
    Type: Application
    Filed: August 8, 2021
    Publication date: June 2, 2022
    Inventors: Vladimir Coric, Robert Croop
  • CGRP ANTAGONISTS FOR TREATING MIGRAINE BREAKTHROUGH
    Publication number: 20210338654
    Abstract: Disclosed are methods of treating breakthrough migraine in patients using breakthrough CGRP antagonists. Also disclosed are methods for the prophylactic treatment of migraine.
    Type: Application
    Filed: January 19, 2020
    Publication date: November 4, 2021
    Inventors: Vladimir Coric, Robert Croop
  • USE OF RILUZOLE ORAL DISINTIGRATING TABLETS FOR TREATING DISEASES
    Publication number: 20210315865
    Abstract: Disclosed are methods of treating a disease in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of riluzole, or a pharmaceutically acceptable salt or prodrug thereof, in the form of an oral solid molded fast-dispersing dosage form. Pharmaceutical compositions and kits are also disclosed.
    Type: Application
    Filed: August 15, 2019
    Publication date: October 14, 2021
    Inventor: Vladimir Coric
  • USE OF RILUZOLE PRODRUGS TO TREAT ALZHEIMER'S DISEASE
    Publication number: 20210290599
    Abstract: Disclosed are methods of treating Alzheimer's Disease by administering to a patient in need thereof a riluzole prodrug such as troriluzole. Pharmaceutical compositions and kits including the riluzole prodrugs are also disclosed.
    Type: Application
    Filed: July 20, 2019
    Publication date: September 23, 2021
    Inventors: Vladimir Coric, Robert Berman, Irfan Qureshi
  • GLUTAMATE AGENTS IN THE TREATMENT OF MENTAL DISORDERS
    Publication number: 20210294011
    Abstract: Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate modulator to an individual in need thereof. Also provided are methods of enhancing the activity of a serotonin reuptake inhibitor (SRI) comprising co-administering a glutamate modulator and a serotonin reuptake inhibitor. Pharmaceutical composition comprising a serotonin reuptake inhibitor and a glutamate modulator are also provided.
    Type: Application
    Filed: June 4, 2021
    Publication date: September 23, 2021
    Inventors: Vladimir Coric, John H. Krystal, Gerard Sanacora
  • Rimegepant for CGRP related disorders
    Patent number: 11083724
    Abstract: Disclosed are methods of treating CGRP related disorders, e.g., migraine, by administering to a patient in need thereof rimegepant or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising rimegepant and kits including the pharmaceutical compositions and instructions are also disclosed.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: August 10, 2021
    Assignee: Biohaven Pharmaceutical Ireland DAC
    Inventors: Vladimir Coric, Robert Croop