Abstract: A computer-assisted method that includes: receiving data encoding parameters defining a study plan of a clinical trial with more than one participant clinical sites; adding a first cohort to the study plan; adding a second cohort to the study plan, the second cohort having no overlapping patient with the first cohort; subsequent to onset of the clinical trial, receiving de-identified information encoding attributes of participant human subjects at each of the clinical sites; parsing the received de-identified information to map the participant human subjects to a particular cohort of the study plan; in response to receiving update information encoding attributes of the participant human subjects at each of the clinical sites, longitudinally tracking the de-identified participant human subjects as mapped to corresponding cohorts of the study plan while the clinical trial progresses at the clinical sites; and providing analytics of the cohorts of the study plan.