Abstract: Systems, devices, and methods for determining a distance between a distal end of an endoscope and a target during an endoscopic procedure are disclosed. A surgical laser feedback control system comprises a feedback analyzer and a controller. The feedback analyzer can receive at least two reflected signals from a target in response to electromagnetic radiation directed at the target. The at least two reflected signals correspond to respective different distances between a distal end of a device of a surgical laser system and the target. The feedback analyzer can determine a distance between the distal end of the device of the surgical laser system and the target based on the at least two reflected signals. The controller can generate a control signal to the surgical laser system to perform a predetermined operation based on the determined distance.

Abstract: A line scanner assembly includes a cam with a cam surface, where the cam rotatable about a cam axis of rotation and includes a first ferromagnetic material. A mirror with a planar surface is configured to tilt about a mirror axis of rotation. A follower is attached to the mirror and has a second ferromagnetic material, where the first magnetic material and/or the second magnetic material includes a permanent magnet and where the follower maintains contact with the cam due to a magnetic attraction between the first ferromagnetic material and the second ferromagnetic material.

Abstract: A ring optical resonator and one or more input optical waveguides are arranged on a substrate, and are arranged and positioned to establish evanescent optical coupling between them. The ring optical resonator, the substrate, or both include one or more nonlinear optical materials. To detect an electromagnetic signal at frequency ?EM incident on the resonator, an input optical signal at frequency ?IN propagates along the waveguide and around the resonator. The incident electromagnetic signal and the input optical signal generate one or more sideband optical signals at corresponding optical sideband frequencies ?SF=?IN+?EM or ?DF=?IN??EM. To generate an electromagnetic signal to propagate away from the resonator, input optical signals at frequencies ?IN1 and ?IN2 propagate along one or more waveguides and around the resonator and generate the electromagnetic signal incident at frequency ?EM=|?IN1??IN2|.

Abstract: A microneedle has a proximal end portion and a distal end portion and defines a lumen. The proximal end portion is configured to be coupled to a cartridge to place the lumen in fluid communication with the cartridge. The proximal end portion includes a base surface that is configured to be placed in contact with a surface of a target tissue. The distal end portion of the microneedle includes a beveled surface. The beveled surface defines a tip angle of less than about 20 degrees and a ratio of a bevel height to a bevel width of less than about 2.5.

Abstract: A ring optical resonator and one or more input optical waveguides are arranged on a substrate, and are arranged and positioned to establish evanescent optical coupling between them. The ring optical resonator, the substrate, or both include one or more nonlinear optical materials. To detect an electromagnetic signal at frequency ?EM incident on the resonator, an input optical signal at frequency ?IN propagates along the waveguide and around the resonator. The incident electromagnetic signal and the input optical signal generate one or more sideband optical signals at corresponding optical sideband frequencies ?SF=?IN+?EM or ?DF=?IN??EM. To generate an electromagnetic signal to propagate away from the resonator, input optical signals at frequencies ?IN1 and ?IN2 propagate along one or more waveguides and around the resonator and generate the electromagnetic signal incident at frequency ?EM=|?IN1??IN2|.

Abstract: A linearly polarized upconverting optical signal at optical frequency ?OPT and a propagating input signal at frequency ?GHz are combined by an input beam combiner to copropagate through a nonlinear optical medium and generate upconverted optical signals at one or both sum or difference frequencies ?SUM=?OPT+?GHz or ?DIFF=?OPT??GHz. The orthogonally polarized upconverting and upconverted optical signals are separated by a polarizer, and the upconverted optical signal is preferentially transmitted to a detection system by an optical filter. The input signal is modulated to encode transmitted information, and that modulation is imparted onto the upconverted optical signal. The detection system includes one or more photodetectors, receives the upconverted optical signal, and generates therefrom electrical signals that are modulated to encode the transmitted information.

Abstract: The present disclosure refers to a method for producing a laminated holographic display comprising the following steps; providing a display precursor, wherein the display precursor comprises a first glass layer, a second glass layer, an unrecorded photopolymer film layer, which is arranged between the first glass layer and the second glass layer, and a polymer film layer, which is arranged between the unrecorded photopolymer film layer and the second glass layer, wherein the providing step is performed in the absence of ambient light; laminating the display precursor to obtain a display laminate, wherein the laminating step is performed in the absence of ambient light; and recording a hologram in the display laminate by applying a light beam to the unrecorded photopolymer film layer of the display laminate to obtain a recorded photopolymer film layer comprising the hologram, wherein the recording step is performed in the absence of ambient light.

Abstract: The invention is directed to methods for diagnosis and differentiation of neurodegenerative diseases (NDs), by quantifying miRNAs in bodily fluids.

Abstract: A linearly polarized upconverting optical signal at optical frequency ?OPT and a propagating input signal at frequency ?GHz are combined by an input beam combiner to copropagate through a nonlinear optical medium and generate upconverted optical signals at one or both sum or difference frequencies ?SUM=?OPT+?GHz or ?DIFF=?OPT??GHz. The orthogonally polarized upconverting and upconverted optical signals are separated by a polarizer, and the upconverted optical signal is preferentially transmitted to a detection system by an optical filter. The input signal is modulated to encode transmitted information, and that modulation is imparted onto the upconverted optical signal. The detection system includes one or more photodetectors, receives the upconverted optical signal, and generates therefrom electrical signals that are modulated to encode the transmitted information.

Abstract: The invention is directed to methods for early diagnosis, progression and treatment monitoring of Parkinson's disease (PD) and its differentiation from other neurodegenerative diseases by quantifying brain-enriched miRNA in bodily fluids.

Abstract: Unlike the existing powered air-purifying respirators (PAPR) that are bulky, heavy, and expensive the invention offers a light-weighted inexpensive portable PAPR consisted of a single piece secured on user's head. The respirator is for use in contaminated environment including one with highly contagious viruses such as SARS-CoV-2 that causes COVID-19. A clear visor of the respirator protects eyes, nose, and mouth. The rest of the user's head protected with a soft airtight cover. A small fan or fans pump air through the filters. Because the fan capacity exceeds airflow required for breathing, air pressure under the cover is slightly higher than ambient pressure. It protects the visor and user glasses from fogging and prevents leaks through any looseness. A special port allows use of equipment and devices as a stethoscope for medics or oxygen supply for patients.

Abstract: The invention provides methods for diagnosis and monitoring of Rett syndrome and other neurodevelopmental disorders by quantitative analysis of miRNAs in bodily fluids.

Abstract: The subject of this invention is a laterally unconstrained magnetic joint and application of said joint in tip-tilt and piston-tip-tilt optical mounts. The laterally unconstrained magnetic joint in its basic embodiment comprises two interfacing parts: one having a flat surface interfacing a convex surface of the other, wherein one or both parts are made from permanent magnets that are magnetized along the axis of the joint, and the other of the said parts is made from a ferromagnetic material thus creating magnetic force attraction between the two parts. The resulting lack of lateral mechanical constraint between the two parts of the joint is utilized in tip-tilt mounts by decoupling an adjustor and/or actuator from the payload resulting in a simple, uniform design, while magnetic force provides retention sufficient for a wide variety of applications.

Abstract: The present invention is directed to methods for detection, treatment monitoring, and slowing of aging by quantifying miRNAs in bodily fluids.

Abstract: A power tong is provided for rotating a pipe, the power tong comprising: a frame having a pair of arcuate front portions defining a throat for receiving the pipe; a ring gear mounted for rotation on the arcuate front portions about a center of rotation, the ring gear having an opening that is alignable with the throat; and a cage plate assembly mounted for rotation on the ring gear on a bearing arrangement that includes roller bearings and a bushing sliding segment on each side of the throat. Taking the throat as having a center line that defines a zero circumferential position within the power tong, the bearing sliding segments may be located within 90 degrees of the throat center line.

Abstract: A laterally unconstrained magnetic joint has a first component comprising a permanent magnet material; and a second component comprising a permanent magnet or ferromagnetic material, where the first component and the second component are magnetically attracted to each other, and where the first component and the second component interface via continuous interface surfaces of different curvature that form and maintain point contact throughout a range of angular and lateral actuation. Movement of the first component is laterally unconstrained with respect to the second component. One or more such magnetic joints can be used in a mount for a payload, such as an wide angle optical mount with three degrees of freedom. The mount may include linear actuators to position the payload.

Abstract: Systems and methods for driving a pixel of a liquid crystal pixel array with a driving circuit are provided. An exemplary method includes: providing a data signal (Dm) to a storage element via the first transistor (T1); and providing a ramping voltage signal (VRAMP) to a gate of a second transistor (T2) of the driving circuit to control the on-off status of the second transistor (T2); wherein the ramping voltage signal (VRAMP) is based on data stored at the storage element; and wherein a duration of an on-state of the second transistor (T2) corresponds to a transmitting state for the pixel.

Abstract: A standing helix ferroelectric liquid crystal display cell includes: two transparent substrates (102A, 102B); a ferroelectric liquid crystal layer (104) comprising ferroelectric liquid crystals in a standing helix configuration, the ferroelectric liquid crystal layer (104) being disposed between the two transparent substrates (102A, 102B), the ferroelectric liquid crystals having a helix axis perpendicular to the two substrates (102A, 102B) and chiral smectic liquid crystal helix pitch shorter than a wavelength of a polarized light normally impinging at least one of the two transparent substrates (102A, 102B); and inter-digital electrodes (105), disposed in plane with the two transparent substrates (102A, 102B), configured to apply an electric field to the ferroelectric liquid crystal layer (104) that provides a driving voltage below a critical voltage for helix unwinding.

Abstract: The present disclosure refers to a method (200) for producing a laminated holographic display (100) comprising the following steps; providing (201) a display precursor (100-1), wherein the display precursor (100-1) comprises a first glass layer (113), a second glass layer (115), an unrecorded photopolymer film layer (117, 117-1), which is arranged between the first glass layer (113) and the second glass layer (115), and a polymer film layer (119), which is arranged between the unrecorded photopolymer film layer (117, 117-1) and the second glass layer (115), wherein the providing step (201) is performed in the absence of ambient light; laminating (203) the display precursor (100-1) to obtain a display laminate (100-2), wherein the laminating step (203) is performed in the absence of ambient light; and recording (205) a hologram (111) in the display laminate (100-2) by applying a light beam to the unrecorded photopolymer film layer (117, 117-1) of the display laminate (100-2) to obtain a recorded photopolymer f

Abstract: The invention is directed to methods for diagnosis and differentiation of neurodegenerative diseases (NDs), by quantifying miRNAs in bodily fluids.