Patents by Inventor Vladimir Gerzanich

Vladimir Gerzanich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING LUNG INJURY
    Publication number: 20230165880
    Abstract: The present invention provides methods of reducing lung injury in a subject in need thereof, comprising administering to the subject an effective amount of an agent that inhibits the activity of SUR1.
    Type: Application
    Filed: April 23, 2021
    Publication date: June 1, 2023
    Inventors: J. Marc Simard, Vladimir Gerzanich, Caron M. Hong
  • COMPOSITIONS AND METHODS FOR TREATING PAIN
    Publication number: 20210046094
    Abstract: The present invention provides a method of treating pain in a subject in need thereof, comprising administering to the subject an effective amount of an agent that inhibits the activity of an NCCa-ATP channel
    Type: Application
    Filed: February 27, 2019
    Publication date: February 18, 2021
    Inventors: J. Marc Simard, Vladimir Gerzanich
  • METHODS FOR ANTAGONISTS OF A NON-SELECTIVE CATION CHANNEL IN NEURAL CELLS
    Publication number: 20190111137
    Abstract: The present invention is directed to a combination of therapeutic compounds and treatment methods and kits using the combination. In particular, one of the combination affects the NCCa-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system. Exemplary SUR1 and/or TRPM4 antagonists that inhibit the NCCa-ATP channel may be employed in the combination. The combination therapy also employs one or more of a non-selective cation channel blocker and/or an antagonist of VEFG, NOS, MMP, or thrombin. Exemplary indications for the combination therapy includes the prevention, diminution, and/or treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury, for example.
    Type: Application
    Filed: May 8, 2018
    Publication date: April 18, 2019
    Inventors: J. Marc Simard, Vladimir Gerzanich
  • ANTAGONISTS OF A NON-SELECTIVE CATION CHANNEL IN NEURAL CELLS
    Publication number: 20100092469
    Abstract: The present invention is directed to a combination of therapeutic compounds and treatment methods and kits using the combination. In particular, one of the combination affects the NCca-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system. Exemplary SUR1 and/or TRPM4 antagonists that inhibit the NCca-ATP channel may be employed in the combination. The combination therapy also employs one or more of a non-selective cation channel blocker and/or an antagonist of VEFG, NOS, MMP, or thrombin. Exemplary indications for the combination therapy includes the prevention, diminution, and/or treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury, for example.
    Type: Application
    Filed: February 8, 2008
    Publication date: April 15, 2010
    Inventors: J. Marc Simard, Vladimir Gerzanich