Patents by Inventor Vladimir Grinevich

Vladimir Grinevich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • -pyridino containing compounds for the use in the treatment of CNS pathologies
    Patent number: 8546415
    Abstract: N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: October 1, 2013
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Linda P. Dwoskin, Joshua Ayers, Vladimir Grinevich, Sangeetha Sumithran
  • BIS-PYRINDINO CONTAINING COMPOUNDS FOR THE USE IN THE TREATMENT OF CNS PATHOLOGIES
    Publication number: 20100152237
    Abstract: N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.
    Type: Application
    Filed: February 26, 2010
    Publication date: June 17, 2010
    Applicant: University of Kentucky Research Foundation
    Inventors: Peter A. CROOKS, Linda P. Dwoskin, Joshua Ayers, Vladimir Grinevich, Sangeetha Sumithran
  • Composition and pharmacology of novel alpha6-containing nicotinic acetylcholine receptors
    Publication number: 20090068642
    Abstract: Nicotinic acetylcholine receptors (nAChRs) comprising the ?6 receptor subunit; nucleic acids, including vectors, comprising subunit incoding sequences; cells expressing the nAChRs of the invention; and methods of screening compounds are provided.
    Type: Application
    Filed: March 23, 2006
    Publication date: March 12, 2009
    Inventors: Merouane Bencherif, Ronald J. Lukas, Sharon Rae Letchworth, Vladimir Grinevich
  • Bis-pyridino containing compounds for the use in the treatment of CNS pathologies
    Publication number: 20080287490
    Abstract: N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.
    Type: Application
    Filed: July 17, 2008
    Publication date: November 20, 2008
    Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Peter A. Crooks, Linda P. Dwoskin, Joshua Ayers, Vladimir Grinevich, Sangeetha Sumithran
  • Bis-pyridino containing compounds for the use in the treatment of CNS pathologies
    Publication number: 20050261334
    Abstract: N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.
    Type: Application
    Filed: January 3, 2005
    Publication date: November 24, 2005
    Inventors: Peter Crooks, Linda Dwoskin, Joshua Ayers, Vladimir Grinevich, Sangeetha Sumithran
  • Method for the evaluation of the efficiency of a therapeutic action upon the human organism
    Publication number: 20050047997
    Abstract: The present invention pertains to the field of medicine and more precisely relates to a method for diagnosing the action of medical preparations as well as medicating, psycho-corrective, mechanical and physiotherapeutic actions applied on the organism of a patient. This invention may be used in the field of pharmacy as well as in the practice in therapy institutes. After a preliminary study, the method of the present invention comprises selecting a research group and monitoring a group including patients of the same sex and approximately the same age. The patients are applied the therapy to be studied and a monitoring is carried out before drawing the conclusions about efficiency according to the treatment of the disease or the recovery and/or the prevention of a pathological symptom occurrence.
    Type: Application
    Filed: January 12, 2004
    Publication date: March 3, 2005
    Inventor: Vladimir Grinevich