Patents by Inventor Vladimir Joukov

Vladimir Joukov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
    Patent number: 6361946
    Abstract: Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: March 26, 2002
    Assignees: Licentia Ltd, Ludwig Institute for Cancer Research
    Inventors: Kari Alitalo, Vladimir Joukov
  • Receptor ligand
    Patent number: 6245530
    Abstract: Provided are ligands for the receptor tyrosine kinase, Flt4. Also provided are cDNAs and vectors encoding the ligands, pharmaceutical compositions and diagnostic reagents.
    Type: Grant
    Filed: January 12, 1996
    Date of Patent: June 12, 2001
    Assignees: Ludwig Institute for Cancer Research, Helsinki University Licensing, Ltd. OY
    Inventors: Kari Alitalo, Vladimir Joukov
  • FIt4 ligand and methods of use
    Patent number: 6221839
    Abstract: Provided are ligands for the receptor tyrosine kinase, Flt4. Also provided are cDNAs and vectors encoding the ligand, pharmaceutical compositions and diagnostic reagents.
    Type: Grant
    Filed: August 1, 1995
    Date of Patent: April 24, 2001
    Assignees: Helsinki University Licensing Ltd. Oy, Ludwig Institute for Cancer Research
    Inventors: Kari Alitalo, Vladimir Joukov
  • Vascular endothelial growth factor C (VEGF-C) .DELTA.Cys.sub.156 protein and gene, and uses thereof
    Patent number: 6130071
    Abstract: Provided are purified and isolated VEGF-C cysteine deletion variants that bind to Flt4 receptor tyrosine kinase (VEGFR-3) but demonstrate reduced binding (relative to VEGF-C) to kdr receptor tyrosine kinase (VEGFR-2); polynucleotides encoding the polypeptide; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the foregoing.
    Type: Grant
    Filed: February 5, 1997
    Date of Patent: October 10, 2000
    Assignee: Helsinki University Licensing, Ltd.
    Inventors: Kari Alitalo, Vladimir Joukov