Patents by Inventor Vladimir Kepe

Vladimir Kepe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIODEGRADABLE ADHESIVE WITH RADIOISOTOPES
    Publication number: 20220040499
    Abstract: A radioactive biodegradable adhesive system can include a first component and a second component. The second component can include a radioactive material. The first component and the second component are configured to polymerize to form a radioactive bolus. A method for treating a patient in need of brachytherapy can include providing the radioactive biodegradable adhesive system. The first component and the second component can be applied to a predetermined location to form the radioactive bolus at the predetermined location.
    Type: Application
    Filed: August 10, 2021
    Publication date: February 10, 2022
    Inventors: Charles Martin, III, Vladimir Kepe
  • Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease
    Patent number: 8845999
    Abstract: Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with 18F, 123I, or 124I, or free hexoses radiolabeled with 18F, 123I, or 124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.
    Type: Grant
    Filed: May 23, 2006
    Date of Patent: September 30, 2014
    Assignee: The Regents of the University of California
    Inventors: Ernest M. Wright, Jorge R. Barrio, Bruce A. Hirayama, Vladimir Kepe
  • In vivo imaging of sulfotransferases
    Patent number: 8372380
    Abstract: Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled with 18F, 123I, 124I, 125I, or 11C. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: February 12, 2013
    Assignee: The Regents of the University of California
    Inventors: Jorge R. Barrio, Vladimir Kepe, Gary W. Small, Nagichettiar Satyamurthy
  • IN VIVO IMAGING OF SULFOTRANSFERASES
    Publication number: 20100135906
    Abstract: Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled with 18F, 123I, 124I, 125I, or 11C. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.
    Type: Application
    Filed: March 31, 2008
    Publication date: June 3, 2010
    Inventors: Jorge R. Barrio, Vladimir Kepe, Small W. Gary, Nagichettiar Satyamurthy
  • TRACERS FOR MONITORING THE ACTIVITY OF SODIUM/GLUCOSE COTRANSPORTERS IN HEALTH AND DISEASE
    Publication number: 20100008856
    Abstract: Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C1 preferred conformation, radio-labeled with 18F, 123I, or 124I, or free hexoses radiolabeled with 18F, 123I, or 124I. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.
    Type: Application
    Filed: May 23, 2006
    Publication date: January 14, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ernest M. Wright, Jorge R. Barrio, Bruce A. Hirayama, Vladimir Kepe
  • Method for Detecting Alzheimer's Disease and other Forms of Dementia, and Measuring Their Progression
    Publication number: 20070218002
    Abstract: The invention provides a method for detecting or monitoring Alzheimer's disease and other forms of dementia using positron emission tomography (PET) or single-photon emission computed tomagraphy (SPECT) and radiolabeled, serotonin 5-HT1A receptor-specific tracers (such as [F-18]MPPF, [F-18]FCWAY, [C-11]WAY-100635, and other radiolabeled compounds having agonistic or antagonistic effect on serotonin receptors), for detection or monitoring of pathological changes (i.e., neuronal cell loss) associated with dementia.
    Type: Application
    Filed: May 9, 2005
    Publication date: September 20, 2007
    Inventors: Jorge Barrio, Vladimir Kepe, Gary Small
  • Methods for binding agents to b-amyloid plaques
    Publication number: 20070053831
    Abstract: A method for labeling structures, such as ?-amyloid plaques and neurofibrillary tangles, in vivo or in vitro, is provided and comprises contacting brain tissue with one or more compounds, preferably radiolabeled for detection by positron emission tomography (PET).
    Type: Application
    Filed: May 20, 2004
    Publication date: March 8, 2007
    Inventors: Jorge Barrio, Andre Petric, Nagichettiar Satyamurthy, Vladimir Kepe, Gary Small