Abstract: A device for treatment of the Peyronie's disease, containing a hollow cylindrical body placed in the bed of a fixed base plate for precision positioning of the penis with respect to the center of the plaque in its subcutaneous tissue, wherein adjacent to the cylindrical body is the face of the shock wave generator firmly connected to a supporting rigid navigation frame with the possibility of travel in three mutually orthogonal directions and three rotations in three mutually perpendicular planes to ensure the localization of the highest shock wave energy level in the second focal point of the shock wave generator which is identical to the position of the center of the plaque, and the space between the inner and outer walls of the cylindrical body is filled with degassed water with a temperature close to the patient's temperature.