Patents by Inventor Vladimir Leo Gilman
Vladimir Leo Gilman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9982262Abstract: The invention generally relates to isolated nucleic acid ligands that are neutral under physiological conditions.Type: GrantFiled: August 3, 2017Date of Patent: May 29, 2018Assignee: VIVONICS, INC.Inventor: Vladimir Leo Gilman
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Publication number: 20170327826Abstract: The invention generally relates to isolated nucleic acid ligands that are neutral under physiological conditions.Type: ApplicationFiled: August 3, 2017Publication date: November 16, 2017Inventor: Vladimir Leo Gilman
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Patent number: 9725724Abstract: The invention generally relates to isolated nucleic acid ligands that are neutral under physiological conditions.Type: GrantFiled: May 15, 2014Date of Patent: August 8, 2017Assignee: Vivonics, Inc.Inventor: Vladimir Leo Gilman
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Patent number: 9303263Abstract: The invention generally relates to aptamers that bind CD271. In certain aspects, the invention provides an isolated nucleic acid ligand that binds to CD271, in which the nucleic acid ligand includes the nucleotide sequence of SEQ ID NO: 1 or the nucleotide sequence of SEQ ID NO: 2.Type: GrantFiled: February 28, 2014Date of Patent: April 5, 2016Assignee: VIVONICS, INC.Inventor: Vladimir Leo Gilman
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Publication number: 20150376619Abstract: The invention generally relates to aptamers that bind CD271. In certain aspects, the invention provides an isolated nucleic acid ligand that binds to CD271, in which the nucleic acid ligand includes the nucleotide sequence of SEQ ID NO: 1 or the nucleotide sequence of SEQ ID NO: 2.Type: ApplicationFiled: February 28, 2014Publication date: December 31, 2015Applicant: VIVONICS, INC.Inventor: Vladimir Leo Gilman
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Publication number: 20150330978Abstract: Morpholino ligands that have high specificity for targets, such as proteins, and that bind their targets through non Watson-Crick base pairing, are described. The use of such morpholino ligands for targeted delivery of loads, such as drugs or labels, are disclosed.Type: ApplicationFiled: May 15, 2014Publication date: November 19, 2015Applicant: VIVONICS, INC.Inventor: Vladimir Leo Gilman
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Patent number: 9085773Abstract: The present invention generally relates to methods for identifying nucleic acid ligands of a target molecule. In certain embodiments, the invention provides methods for identifying a nucleic acid ligand of a target molecule from a candidate mixture of nucleic acids, including contacting at least one target molecule with a candidate mixture of nucleic acids, in which the nucleic acids have different affinities for the target molecule, and separating in a single step nucleic acids that bind the target molecule with greatest affinity from nucleic acids that bind the target molecule with a lesser affinity and nucleic acids that do not bind the target molecule, thereby identifying the nucleic acid ligand of the target molecule.Type: GrantFiled: May 7, 2013Date of Patent: July 21, 2015Assignee: Vivonics, Inc.Inventor: Vladimir Leo Gilman
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Patent number: 9068982Abstract: The invention generally relates to nucleic acid ligands that specifically bind to infectious prions, and methods of diagnosing a transmissible spongiform encephalopathy disease in a subject. In certain embodiments, the invention provides an isolated nucleic acid ligand that binds to an infectious prion. In other embodiments, the invention provides a method for diagnosing a transmissible spongiform encephalopathy disease in a subject including obtaining a tissue or body fluid sample from a subject, contacting the tissue or body fluid with a nucleic acid ligand that binds to an infectious prion, thereby detecting the infectious prion in the sample, and diagnosing the transmissible spongiform encephalopathy disease based on results of the contacting step.Type: GrantFiled: January 13, 2011Date of Patent: June 30, 2015Assignee: Vivonics, Inc.Inventor: Vladimir Leo Gilman
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Publication number: 20140377744Abstract: The invention generally relates to nucleic acid ligands that specifically bind to infectious prions, and methods of diagnosing a transmissible spongiform encephalopathy disease in a subject. In certain embodiments, the invention provides an isolated nucleic acid ligand that binds to an infectious prion. In other embodiments, the invention provides a method for diagnosing a transmissible spongiform encephalopathy disease in a subject including obtaining a tissue or body fluid sample from a subject, contacting the tissue or body fluid with a nucleic acid ligand that binds to an infectious prion, thereby detecting the infectious prion in the sample, and diagnosing the transmissible spongiform encephalopathy disease based on results of the contacting step.Type: ApplicationFiled: August 15, 2014Publication date: December 25, 2014Inventor: Vladimir Leo Gilman
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Publication number: 20140343264Abstract: The invention generally relates to isolated nucleic acid ligands that are neutral under physiological conditions.Type: ApplicationFiled: May 15, 2014Publication date: November 20, 2014Applicant: Vivonics, Inc.Inventor: Vladimir Leo Gilman
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Patent number: 8841429Abstract: The invention generally relates to nucleic acid ligands that specifically bind to infectious prions, and methods of diagnosing a transmissible spongiform encephalopathy disease in a subject. In certain embodiments, the invention provides an isolated nucleic acid ligand that binds to an infectious prion. In other embodiments, the invention provides a method for diagnosing a transmissible spongiform encephalopathy disease in a subject including obtaining a tissue or body fluid sample from a subject, contacting the tissue or body fluid with a nucleic acid ligand that binds to an infectious prion, thereby detecting the infectious prion in the sample, and diagnosing the transmissible spongiform encephalopathy disease based on results of the contacting step.Type: GrantFiled: November 3, 2009Date of Patent: September 23, 2014Assignee: Vivonics, Inc.Inventor: Vladimir Leo Gilman
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Publication number: 20130273551Abstract: The present invention generally relates to methods for identifying nucleic acid ligands of a target molecule. In certain embodiments, the invention provides methods for identifying a nucleic acid ligand of a target molecule from a candidate mixture of nucleic acids, including contacting at least one target molecule with a candidate mixture of nucleic acids, in which the nucleic acids have different affinities for the target molecule, and separating in a single step nucleic acids that bind the target molecule with greatest affinity from nucleic acids that bind the target molecule with a lesser affinity and nucleic acids that do not bind the target molecule, thereby identifying the nucleic acid ligand of the target molecule.Type: ApplicationFiled: May 7, 2013Publication date: October 17, 2013Inventor: Vladimir Leo Gilman
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Patent number: 8460899Abstract: The present invention generally relates to methods for identifying nucleic acid ligands of a target molecule. In certain embodiments, the invention provides methods for identifying a nucleic acid ligand of a target molecule from a candidate mixture of nucleic acids, including contacting at least one target molecule with a candidate mixture of nucleic acids, in which the nucleic acids have different affinities for the target molecule, and separating in a single step nucleic acids that bind the target molecule with greatest affinity from nucleic acids that bind the target molecule with a lesser affinity and nucleic acids that do not bind the target molecule, thereby identifying the nucleic acid ligand of the target molecule.Type: GrantFiled: June 29, 2012Date of Patent: June 11, 2013Assignee: Vivonics, Inc.Inventor: Vladimir Leo Gilman
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Publication number: 20120301890Abstract: The present invention generally relates to methods for identifying nucleic acid ligands of a target molecule. In certain embodiments, the invention provides methods for identifying a nucleic acid ligand of a target molecule from a candidate mixture of nucleic acids, including contacting at least one target molecule with a candidate mixture of nucleic acids, in which the nucleic acids have different affinities for the target molecule, and separating in a single step nucleic acids that bind the target molecule with greatest affinity from nucleic acids that bind the target molecule with a lesser affinity and nucleic acids that do not bind the target molecule, thereby identifying the nucleic acid ligand of the target molecule.Type: ApplicationFiled: June 29, 2012Publication date: November 29, 2012Applicant: INFOSCITEX CORPORATIONInventor: Vladimir Leo Gilman
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Patent number: 8236570Abstract: The present invention generally relates to methods for identifying nucleic acid ligands of a target molecule. In certain embodiments, the invention provides methods for identifying a nucleic acid ligand of a target molecule from a candidate mixture of nucleic acids, including contacting at least one target molecule with a candidate mixture of nucleic acids, in which the nucleic acids have different affinities for the target molecule, and separating in a single step nucleic acids that bind the target molecule with greatest affinity from nucleic acids that bind the target molecule with a lesser affinity and nucleic acids that do not bind the target molecule, thereby identifying the nucleic acid ligand of the target molecule.Type: GrantFiled: November 3, 2009Date of Patent: August 7, 2012Assignee: InfoscitexInventor: Vladimir Leo Gilman
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Publication number: 20110136111Abstract: The invention generally relates to nucleic acid ligands that specifically bind to infectious prions, and methods of diagnosing a transmissible spongiform encephalopathy disease in a subject. In certain embodiments, the invention provides an isolated nucleic acid ligand that binds to an infectious prion. In other embodiments, the invention provides a method for diagnosing a transmissible spongiform encephalopathy disease in a subject including obtaining a tissue or body fluid sample from a subject, contacting the tissue or body fluid with a nucleic acid ligand that binds to an infectious prion, thereby detecting the infectious prion in the sample, and diagnosing the transmissible spongiform encephalopathy disease based on results of the contacting step.Type: ApplicationFiled: January 13, 2011Publication date: June 9, 2011Applicant: INFOSCITEX CORPORATIONInventor: Vladimir Leo Gilman
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Publication number: 20110104668Abstract: The invention generally relates to nucleic acid ligands that specifically bind to infectious prions, and methods of diagnosing a transmissible spongiform encephalopathy disease in a subject. In certain embodiments, the invention provides an isolated nucleic acid ligand that binds to an infectious prion. In other embodiments, the invention provides a method for diagnosing a transmissible spongiform encephalopathy disease in a subject including obtaining a tissue or body fluid sample from a subject, contacting the tissue or body fluid with a nucleic acid ligand that binds to an infectious prion, thereby detecting the infectious prion in the sample, and diagnosing the transmissible spongiform encephalopathy disease based on results of the contacting step.Type: ApplicationFiled: November 3, 2009Publication date: May 5, 2011Applicant: INFOSCITEX CORPORATIONInventor: Vladimir Leo Gilman
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Publication number: 20110104667Abstract: The present invention generally relates to methods for identifying nucleic acid ligands of a target molecule. In certain embodiments, the invention provides methods for identifying a nucleic acid ligand of a target molecule from a candidate mixture of nucleic acids, including contacting at least one target molecule with a candidate mixture of nucleic acids, in which the nucleic acids have different affinities for the target molecule, and separating in a single step nucleic acids that bind the target molecule with greatest affinity from nucleic acids that bind the target molecule with a lesser affinity and nucleic acids that do not bind the target molecule, thereby identifying the nucleic acid ligand of the target molecule.Type: ApplicationFiled: November 3, 2009Publication date: May 5, 2011Applicant: INFOSCITEX CORPORATIONInventor: Vladimir Leo Gilman