Patents by Inventor Vladimir N. Kokryakov
Vladimir N. Kokryakov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040152638Abstract: Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin.Type: ApplicationFiled: July 24, 2003Publication date: August 5, 2004Applicant: The Regents of the University of CaliforniaInventors: Robert I. Lehrer, Sylvia S.L. Harwig, Vladimir N. Kokryakov
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Patent number: 6653442Abstract: Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin.Type: GrantFiled: August 30, 1999Date of Patent: November 25, 2003Assignee: IntraBiotics Pharmaceuticals, Inc.Inventors: Conway C. Chang, Chee L. Gu, Jie Chen, Deborah A. Steinberg, Robert I. Lehrer, Sylvia S. L. Harwig, Vladimir N. Kokryakov
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Publication number: 20030100483Abstract: Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin.Type: ApplicationFiled: March 30, 2000Publication date: May 29, 2003Inventors: Robert I. Lehrer, Sylvia S.L. Harwig, Vladimir N. Kokryakov
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Patent number: 6159936Abstract: Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin. These compounds, in one embodiment, are of the formula:A.sub.1 --A.sub.2 --A.sub.3 --A.sub.4 --A.sub.5 --A.sub.6 --A.sub.7 --A.sub.8 --A.sub.9 --A.sub.10 --A.sub.11 --A.sub.12 --A.sub.13 --A.sub.14 --A.sub.15 --A.sub.16 --(A.sub.17 --A.sub.18) (1)and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, which is either in the optionally --SH stablizied linear or in a cystine-bridged formwherein each of A.sub.1 and A.sub.9 is independently a basic amino acid;each of A.sub.2 and A.sub.3 is independently a small amino acid;each of A.sub.5, A.sub.7, A.sub.12, A.sub.14 and A.sub.16 is independently a hydrophobic amino acid;A.sub.Type: GrantFiled: August 3, 1998Date of Patent: December 12, 2000Assignee: The Regents of the University of CaliforniaInventors: Robert I. Lehrer, Sylvia S. L. Harwig, Vladimir N. Kokryakov
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Patent number: 5889152Abstract: Peptide-based compounds containing multiple proline residues are useful as preservatives and in preventing, treating, or ameliorating microbial infection, especially Gram-negative bacterial infection in animals and plants, in treating conditions characterized by the presence of LPS. These compounds are of the formula ##STR1## including the N-terminal acylated and/or C-terminal amidated or esterified forms thereofwherein each of A.sub.1, A.sub.5, A.sub.10, A.sub.14 and A.sub.20 is independently Ala, Gly or Ser;each of A.sub.2, A.sub.4, A.sub.7, A.sub.9, A.sub.11, A.sub.12, A.sub.13, A.sub.16, A.sub.17, A.sub.19 and A.sub.22 is independently a hydrophobic amino acid selected from the group consisting of Ile, Leu, Val, Phe and Met;each of A.sub.3 and A.sub.8 is independently a neutral polar amino acid selected from Asn and Gln or is a hydrophobic amino acid selected from the group consisting of Ile, Leu, Val, Phe and Met;each of A.sub.6, A.sub.18 and A.sub.Type: GrantFiled: June 7, 1995Date of Patent: March 30, 1999Assignee: Regents of the University of CaliforniaInventors: Vladimir N. Kokryakov, Sylvia S.L. Harwig, Robert I. Lehrer
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Patent number: 5804558Abstract: Peptide-based compounds containing four invariant cycteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin. These compounds, in one embodiment, are of the formula: ##STR1## and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, which is either in the optionally -SH stabilized linear or in a cystine-bridged formwherein each of A.sub.1 and A.sub.9 is independently a basic amino acid;each of A.sub.2 and A.sub.3 is independently a small amino acid;each of A.sub.5, A.sub.7, A.sub.12, A.sub.14 and A.sub.16 is independently a hydrophobic amino acid;A.sub.4 is a basic or a small amino acid;A.sub.10 is a basic or a small amino acid or is proline;A.sub.11 is a basic or a hydrophobic amino acid;A.sub.Type: GrantFiled: July 7, 1995Date of Patent: September 8, 1998Assignee: University of CaliforniaInventors: Robert I. Lehrer, Sylvia S. L. Harwig, Vladimir N. Kokryakov
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Patent number: 5804553Abstract: Peptide-based compounds containing multiple proline residues are useful as preservatives and in preventing, treating, or ameliorating microbial infection, especially Gram-negative bacterial infection in animals and plants, in treating conditions characterized by the presence of LPS. These compounds are of the formula ##STR1## including the N-terminal acylated and/or C-terminal amidated or esterified forms thereofwherein each of A.sub.1, A.sub.5, A.sub.10, A.sub.14 and A.sub.20 is independently Ala, Gly or Ser;each of A.sub.2, A.sub.4, A.sub.7, A.sub.9, A.sub.11, A.sub.12, A.sub.13, A.sub.16, A.sub.17, A.sub.19 and A.sub.22 is independently a hydrophobic amino acid selected from the group consisting of Ile, Leu, Val, Phe and Met;each of A.sub.3 and A.sub.8 is independently a neutral polar amino acid selected from Asn and Gln or is a hydrophobic amino acid selected from the group consisting of Ile, Leu, Val, Phe and Met;each of A.sub.6, A.sub.18 and A.sub.Type: GrantFiled: April 5, 1994Date of Patent: September 8, 1998Assignee: University of CaliforniaInventors: Vladimir N. Kokryakov, Sylvia S. L. Harwig, Robert I. Lehrer
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Patent number: 5693486Abstract: Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced, are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin. These compounds, in one embodiment, are of the formula:A.sub.1 -A.sub.2 -A.sub.3 -A.sub.4 -A.sub.5 -C-A.sub.7 -C-A.sub.9 -A.sub.10 -A.sub.11 -A.sub.12 -C-A.sub.14 -C-A.sub.16 -(A.sub.17 -A.sub.18)(1)(SEQ ID NO:1)and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, either in optionally --SH stabilized linear or in cystine-bridged formwherein A.sub.1, A.sub.9, A.sub.10, and A.sub.11 are basic amino acids;A.sub.2 and A.sub.3 are small amino acids;A.sub.5, A.sub.7, A.sub.12, A.sub.14 and A.sub.16 are hydrophobic amino acids; andA.sub.4 is a basic or a small amino acid;A.sub.Type: GrantFiled: January 13, 1994Date of Patent: December 2, 1997Assignee: IntraBioticsInventors: Robert I. Lehrer, Vladimir N. Kokryakov, Sylvia S. L. Harwig
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Patent number: 5635594Abstract: Peptide-based compounds containing six invariant cysteine residues are useful as preservatives and in preventing, treating, or ameliorating microbial infection in animals and plants. These compounds are of the formulas: ##STR1## wherein each B.sub.i is a basic amino acid and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, either in optionally --SH stabilized linear or in cystine-bridged form.Type: GrantFiled: March 11, 1994Date of Patent: June 3, 1997Assignee: University of California, Los AngelesInventors: Robert I. Lehrer, Vladimir N. Kokryakov, Sylvia S. L. Harwig
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Patent number: 5633229Abstract: Peptide-based compounds containing multiple proline residues are useful as preservatives and in preventing, treating, or ameliorating microbial infection, especially Gram-negative bacterial infection in animals and plants, in treating conditions characterized by the presence of LPS. These compounds are of the formula ##STR1## including the N-terminal acylated and/or C-terminal amidated or esterified forms thereofwherein each of A.sub.1, A.sub.5, A.sub.1O, A.sub.14 and A.sub.20 is independently Ala, Gly or Ser;each of A.sub.2, A.sub.4, A.sub.7, A.sub.9, A.sub.11, A.sub.12, A.sub.13, A.sub.16, A.sub.17, A.sub.19 and A.sub.22 is independently a hydrophobic amino acid selected from the group consisting of Ile, Leu, Val, Phe and Met;each of A.sub.3 and A.sub.8 is independently a neutral polar amino acid selected from Asn and Gln or is a hydrophobic amino acid selected from the group consisting of Ile, Leu, Val, Phe and Met;each of A.sub.6, A.sub.18 and A.sub.Type: GrantFiled: June 7, 1995Date of Patent: May 27, 1997Assignee: University of CaliforniaInventors: Vladimir N. Kokryakov, Sylvia S. L. Harwig, Robert I. Lehrer
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Patent number: 5464823Abstract: Peptide-based compounds containing four invariant cysteine residues which have been oxidized to obtain two intramolecular disulfide bonds are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants. These compounds, in one embodiment, are of the formula:A.sub.1 -A.sub.2 -A.sub.3 -A.sub.4 -A.sub.5 -C-A.sub.7 -C-A.sub.9 -A.sub.10 -A.sub.11 -A.sub.12 -C-A.sub.14 -C-A.sub.16 -(A.sub.17 -A.sub.18)(1) (SEQ ID NO:4)and the N-terminal acylated, C-terminal amidated or esterified and the cystine-bridged forms thereofwherein A.sub.1, A.sub.9, A.sub.10 and A.sub.11 are basic amino acids;A.sub.2 and A.sub.3 are small amino acids;A.sub.5, A.sub.7, A.sub.12, A.sub.14 and A.sub.16 are hydrophobic amino acids; andA.sub.4 is a basic or a small amino acid;A.sub.17 is not present or, if present, is a small amino acid;A.sub.18 is not present or, if present, is a basic amino acid.Type: GrantFiled: July 26, 1993Date of Patent: November 7, 1995Assignee: The Regents of the University of CaliforniaInventors: Robert I. Lehrer, Vladimir N. Kokryakov, Sylvia S. L. Harwig