Patents by Inventor Vladimir N. Potaman

Vladimir N. Potaman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SELF REPLICATING RNA FOR INDUCING SOMATIC DIFFERENTIATION OF UNMODIFIED ADULT STEM CELLS
    Publication number: 20200399609
    Abstract: A self-replicating RNA for inducing somatic differentiation of unmodified adult stem cells is described. Methods of differentiating unmodified adult stem cells into functional beta-like cells are also described, as well as compositions, tissues and devices containing such cells. The method requires inducing sequential expression of PDX1 before NGN3, and NGN3 before MAFA in these stem cells to form reprogrammed beta-cells. Self-replicating RNAs are provided and introduced into the adult stem cells to induce the sequential expression. Methods of treating diabetes are also provided, comprising obtaining stem cells, preferably from a patient with diabetes, inducing sequential expression of PDX1>NGN3>MAFA, in said stem cells to form reprogrammed beta-cells, and introducing said reprogrammed beta-cells into a pancreas of said patient.
    Type: Application
    Filed: August 31, 2020
    Publication date: December 24, 2020
    Inventors: Eckhard U. ALT, Tahereh KARIMI, Vladimir N. Potaman
  • Ets2 and Mesp1 generate cardiac progenitors from fibroblasts
    Patent number: 9109232
    Abstract: A method for modulating cell differentiation capabilities using heterologous gene expression. Some embodiments of the invention relate to a method for inducing a cardiac progenitor cell by delivering a reprogramming factor to the cell, wherein the reprogramming factor comprises ETS2 or a combination of ETS2 and Mesp1.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: August 18, 2015
    Assignees: University of Houston, Texas Heart Institute, The Texas A&M University System
    Inventors: Robert J. Schwartz, Vladimir N. Potaman, Jose Francisco Islas
  • ETS2 AND MESP1 GENERATE CARDIAC PROGENITORS FROM FIBROBLASTS
    Publication number: 20140004604
    Abstract: A method for modulating cell differentiation capabilities using heterologous gene expression. Some embodiments of the invention relate to a method for inducing a cardiac progenitor cell by delivering a reprogramming factor to the cell, wherein the reprogramming factor comprises ETS2 or a combination of ETS2 and Mesp1.
    Type: Application
    Filed: June 12, 2013
    Publication date: January 2, 2014
    Applicants: University of Houston, The Texas A&M University System, Texas Heart Institute
    Inventors: Robert J. Schwartz, Vladimir N. Potaman, Jose Francisco Islas
  • ETS2 and MESP1 generate cardiac progenitors from fibroblasts
    Patent number: 8486701
    Abstract: A method for modulating cell differentiation capabilities using heterologous gene expression. Some embodiments of the invention relate to a method for inducing a cardiac progenitor cell by delivering a reprogramming factor to the cell, wherein the reprogramming factor comprises ETS2 or a combination of ETS2 and Mesp1.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: July 16, 2013
    Assignees: University of Houston, Texas Heart Institute, The Texas A&M University System
    Inventors: Robert J. Schwartz, Vladimir N. Potaman, Jose Francisco Islas
  • ETS2 AND MESP1 GENERATE CARDIAC PROGENITORS FROM FIBROBLASTS
    Publication number: 20110223670
    Abstract: A method for modulating cell differentiation capabilities using heterologous gene expression. Some embodiments of the invention relate to a method for inducing a cardiac progenitor cell by delivering a reprogramming factor to the cell, wherein the reprogramming factor comprises ETS2 or a combination of ETS2 and Mesp1.
    Type: Application
    Filed: March 4, 2011
    Publication date: September 15, 2011
    Applicants: Texas Heart Institute, University of Houston, The Texas A&M University System
    Inventors: Robert J. Schwartz, Vladimir N. Potaman, Jose Francisco Islas