Patents by Inventor Vladimir N. Smirnov

Vladimir N. Smirnov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of cold welding
    Patent number: 4756465
    Abstract: A method of cold welding of workpieces formed as axially symmetric bodies of rotation, wherein the workpieces are pressed into each other by applying an axial stress to at least one of the workpieces, and the workpieces are imparted a relative turn in a plane perpendicular to the direction of the axial stress.
    Type: Grant
    Filed: September 9, 1986
    Date of Patent: July 12, 1988
    Assignee: Latviisky Gosudarstvenny Institut
    Inventors: Anatoly S. Pranch, Pavel I. Gursky, Vasily I. Averkin, Petr S. Neminuschy, Vladimir N. Smirnov, Evgeny A. Baranov, Dmitry V. Leontiev, Jury I. Goroshkov, Vladimir N. Lozinsky
  • Hexapeptide
    Patent number: 4698419
    Abstract: A novel hexapeptide having the following structure:Phe-Ala-Gly-Phe-Gly-Arg.The hexapeptide according to the present invention has a hepatoprotective effect.
    Type: Grant
    Filed: February 5, 1986
    Date of Patent: October 6, 1987
    Assignee: Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskikh Nauk SSSR
    Inventors: Evgeny I. Chazov, Vladimir N. Smirnov, Valentin A. Vinogradov, Vladimir M. Polonsky, Valentina A. Tischenko, Mikhail I. Titov, Zhanna D. Bespalova, Boris L. Pekelis
  • Hexapeptide
    Patent number: 4695622
    Abstract: A novel hexapeptide having the following structure:Tyr-Ala-Gly-Phe-Leu-Arg.The hexapeptide according to the present invention possesses an antipancreonecrotic activity.
    Type: Grant
    Filed: February 5, 1986
    Date of Patent: September 22, 1987
    Assignee: Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskikh Nauk SSSR
    Inventors: Evgeny I. Chazov, Vladimir N. Smirnov, Valentin A. Vinogradov, Mikhail I. Titov, Vladimir A. Penin, Alexandr K. Giorgadze, Galina P. Titova, Zhanna D. Bespalova, Boris L. Pekelis, Nikolai K. Permyakov, Sergei I. Emelyanov, Alexandr A. Dzhikia
  • Pharmaceutical preparation for the treatment of peptic ulcer
    Patent number: 4565805
    Abstract: A pharmaceutical preparation or the treatment of peptic ulcer comprising an active principle, notably a peptide of the following structure:Tyr-D-Ala-Gly-Phe-Leu-Argand a pharmaceutically acceptable vehicle.
    Type: Grant
    Filed: July 20, 1984
    Date of Patent: January 21, 1986
    Inventors: Vladimir N. Smirnov, Mikhail I. Titov, Zhanna D. Bespalova, Andrei A. Azmuko, Tatyana R. Sax, Oleg S. Medvedev, Nadezhda I. Rozhanskaya, Vsevolod G. Smagin, Valentin A. Vinogradov, Vladimir M. Polonsky, Sergei A. Bulgakov, Vladimir N. Ivanov
  • Urokinase derivatives covalently bound to fibrinogen
    Patent number: 4564596
    Abstract: Urokinase derivatives comprise urokinase covalently bonded with fibrinogen or urokinase covalently bonded with fibrinogen through an aliphatic diamine and correspond to the general formula: ##STR1## wherein P is fibrinogen, E is urokinase, R is absent or stands for ##STR2## wherein n is 1-12, with a molecular mass of from 360,000 to 440,000 D, a content of protein of 10 to 30% by mass, an esterase catalytic activity of 30-60%.These derivatives have an increased affinity to fibrin and feature a prolonged fibrinolytic effect.
    Type: Grant
    Filed: January 3, 1985
    Date of Patent: January 14, 1986
    Inventors: Alexandr V. Maximenko, Elena G. Tischenko, Vladimir P. Torchilin, Vladimir N. Smirnov, Evgeny I. Chazov
  • Dextran derivative of fibrinolysin
    Patent number: 4446316
    Abstract: A method of preparing a polysaccharide derivative of fibrinolysin which comprises reacting fibrinolysin with dextran dialdehyde having a molecular mass of from 20,000 to 110,000 at a pH of from 8.0 to 9.5 and at a temperature within the range of from 5.degree. to 30.degree. C. with the formation of a covalent bond; the resulting fibrinolysin derivative is reduced with sodium borohydride and isolated.
    Type: Grant
    Filed: December 9, 1981
    Date of Patent: May 1, 1984
    Assignee: Vsesojuzny Kardiologichesky Nauchny Tsentr
    Inventors: Evgeny I. Chazov, Vladimir N. Smirnov, Vladimir P. Torchilin, Igor M. Tereshin, Boris V. Moskvichev, Grigory M. Grinberg, Agris Z. Skuya, Gersh I. Kleiner
  • Heat-resistant water soluble urokinase derivative
    Patent number: 4349630
    Abstract: A heat-resistant water soluble derivative of urokinase is prepared which comprises urokinase covalently bonded to a copolymer of acrylamide and acrylic acid having a molecular weight of 10,000 to 200,000 and a content of acrylic acid of 1% to 2%. The derivative contains 15% to 35% urokinase and has an esterase and amidolytic activity of from 10% to 80%.
    Type: Grant
    Filed: August 27, 1980
    Date of Patent: September 14, 1982
    Inventors: Alexandr V. Maximenko, Vladimir P. Torchilin, Vladimir N. Smirnov, Evgeny I. Chazov
  • Method and apparatus for producing visible image of object
    Patent number: 4257269
    Abstract: A method for producing a visible image of an object is disclosed in which a fermental plate is illuminated with ultrasonic waves and a latent image of the object is therefore produced therein which is developed using a solution of chromogenic substrates, comprising, for example, hydrogen peroxide and a water-soluble aromatic amine. An apparatus to practice the disclosed method comprises an ultrasonic generator to generate ultrasonic waves illuminating the object, a fermental plate to receive and convert the ultrasonic waves passed through the object to a visible image, and a tray filled with a developer to develop the latent image of the object in the fermental plate.
    Type: Grant
    Filed: July 20, 1978
    Date of Patent: March 24, 1981
    Assignee: Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskikh Nauk SSSR
    Inventors: Ilia V. Berezin, Viktor S. Goldmakher, Alexandr M. Klibanov, Karel Martinek, Alexandr A. Mishin, Gennady P. Samokhin, Vladimir N. Smirnov, Vladimir P. Torchilin, Evgeny I. Chazov