Patents by Inventor Vladimir Noskov

Vladimir Noskov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rapid generation of long synthetic centromeric tandem repeats for mammalian artificial chromosome formation
    Patent number: 9139849
    Abstract: Methods are described for construction of long synthetic arrays of DNA repeats, such as alphoid repeats or other repeat sequences. The methods include concatamerization of DNA into short repeats (for instance using rolling circle amplification or directional in vitro ligation), followed by assembling the short repeats into long arrays by homologous recombination during transformation into microbe cells. These methods can be described generally as Recombinational Amplification of Repeats (RAR). The long arrays are engineered centromere-like regions that allow one to construct mammalian artificial chromosomes with a predefined centromeric region structure. Artificial chromosomes, including human artificial chromosomes with a regulated centromere, and methods of their use are also provided.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: September 22, 2015
    Assignees: The United States of America as Represented by the Government of the Department of Health and Human Services, The University Court of the University of Edinburgh
    Inventors: Vladimir L. Larionov, William C. Earnshaw, Reto Gassman, Stefanie Kandels-Lewis, Hiroshi Masumoto, Megumi Nakano, Vladimir Noskov, Natalay Y. Kouprina, Carl J. Barrett, Stefano Cardinale
  • RAPID GENERATION OF LONG SYNTHETIC CENTROMERIC TANDEM REPEATS FOR MAMMALIAN ARTIFICIAL CHROMOSOME FORMATION
    Publication number: 20090136924
    Abstract: Methods are described for construction of long synthetic arrays of DNA repeats, such as alphoid repeats or other repeat sequences. The methods include concatamerization of DNA into short repeats (for instance using rolling circle amplification or directional in vitro ligation), followed by assembling the short repeats into long arrays by homologous recombination during transformation into microbe cells. These methods can be described generally as Recombinational Amplification of Repeats (RAR). The long arrays are engineered centromere-like regions that allow one to construct mammalian artificial chromosomes with a predefined centromeric region structure.
    Type: Application
    Filed: April 8, 2006
    Publication date: May 28, 2009
    Inventors: Vladimir L. Larionov, William C. Earnshaw, Reto Gassman, Stefanie Kandels-Lewis, Hiroshi Masumoto, Megumi Nakano, Stefano Cardinale, Carl J Barrett, Vladimir Noskov, Natalay Y. Kouprina
  • Tandem repeat markers
    Publication number: 20040248289
    Abstract: Disclosed is a vector comprising a marker sequence, a hook capable of attaching the vector to a target molecule, and a vector diagnostic sequence having the same sequence as a target diagnostic sequence contained in the target molecule, wherein the marker, hook, and vector diagnostic sequence are arranged (5′) to (3′) such that the marker would be in between the vector diagnostic sequence and the target diagnostic sequence after the vector and the target molecule are attached via the hook. Also provided is a method of attaching two nucleic acid molecules together, comprising mixing a target molecule and the vector together under conditions that promote the attachment of the target molecule and the vector.
    Type: Application
    Filed: July 26, 2004
    Publication date: December 9, 2004
    Inventors: Vladimir Noskov, Vladimir Larionov, Natalay Kouprina, J. Carl Barrett