Abstract: The invention relates to oncology. The object of this invention is to provide reliable malignant tumor treatment methods, to reduce toxicity of the method and to enhance the role of immunity during the rehabilitation period. The above objects are to be achieved as follows. A method for combined treatment of malignant tumors comprises administering a sensitizing agent and exposing a malignant tumor to wave irradiation, wherein ultrasonic radiation is used as a wave irradiation.