Patents by Inventor Vladimir Petrow

Vladimir Petrow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5661141
    Abstract: The present invention provides compounds and methods of inducing a variety of therapeutic responses in a subject in need of such treatment. The method includes administering a compound of Formula (I) ##STR1## wherein R.sub.1 -R.sub.7 are as defined in the specification; and wherein said compound of Formula (I) is ethylenically unsaturated at a set of locations selected from the group consisting of (a) between C.sub.4 and C.sub.5 ; (b) both between C.sub.3 and C.sub.4 and between C.sub.5 and C.sub.6 ; (c) between C.sub.5 and C.sub.6 ; (d) both between C.sub.4 and C.sub.5 and between C.sub.6 and C.sub.7 ; (e) both between C.sub.3 and C.sub.4 between C.sub.5 and C.sub.6 and between C.sub.7 and C.sub.8 ; (f) both between C.sub.4 and C.sub.5 and between C.sub.7 and C.sub.8 ; and (g) both between C.sub.5 and C.sub.6 and between C.sub.7 and C.sub.8.The compounds of Formula (I) are administered in an amount effective to induce the desired therapeutic response.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: August 26, 1997
    Inventor: Vladimir Petrow
  • Patent number: 5646136
    Abstract: Methods for treating angiogenesis, tumors, and ocular hypertension with steroids are disclosed herein. The steroids have angiostatic activity with reduced glucocorticoid activity.
    Type: Grant
    Filed: January 4, 1994
    Date of Patent: July 8, 1997
    Assignee: Duke University
    Inventors: Vladimir Petrow, Alan D. Proia
  • Patent number: 4396615
    Abstract: A method of treating androgen-related disorders in an animal which comprises administering to the animal dihydrotestosterone level decreasing amounts of a compound of formula (I): ##STR1## wherein R is H or F; R.sup.1 is selected from the group consisting of --H; straight or branched chain lower alkyl; hydroxyl; --OCOR.sup.3 ; and O--(C.sub.1 -C.sub.6 alkyl); wherein R.sup.3 is --H, C.sub.1 -C.sub.10 straight or branched chain alkyl group, phenyl, phenyl alkylene having straight or branched chain C.sub.1 -C.sub.6 alkylene, C.sub.5 -C.sub.10 cycloalkyl or C.sub.6 -C.sub.10 cycloalkyl alkylene; R.sup.2 is H.sub.2, methylene, ethylidene, .alpha.-CH.sub.3 (H), .beta.-CH.sub.3 (H), .alpha.-(OH)(H) or the acetonide derived from the 16.alpha.,17.alpha.-dihydroxy derivative, and n is 1 or 2.
    Type: Grant
    Filed: June 24, 1981
    Date of Patent: August 2, 1983
    Assignee: Duke University
    Inventors: Vladimir Petrow, Leon Lack
  • Patent number: 4317818
    Abstract: Compounds of the following general formula are useful in treating prostatic carcinoma: ##STR1## wherein R is --CHO or --CH.sub.2 OR.sub.1 ; each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R.sub.3 is hydrogen; or R.sub.2 and R.sub.3 together form a double bond between the 17-position carbon atom and the oxygen atom.
    Type: Grant
    Filed: May 28, 1980
    Date of Patent: March 2, 1982
    Assignee: Richardson-Merrell Inc.
    Inventors: Harvey D. Benson, Joyce F. Grunwell, John O. Johnston, Vladimir Petrow
  • Patent number: 4239681
    Abstract: Derivatives of androst-4-en-19-ol are useful for enhancing libido and related psychic attitudes.
    Type: Grant
    Filed: April 15, 1974
    Date of Patent: December 16, 1980
    Assignee: Richardson-Merrell Inc.
    Inventors: Joyce F. Grunwell, Vladimir Petrow
  • Patent number: 4139617
    Abstract: The present invention concerns derivatives of 19-oxygenated-androst-5-enes which are useful in the enhancement of libido and related psychic attitudes.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: February 13, 1979
    Assignee: Richardson-Merrell Inc.
    Inventors: Joyce F. Grunwell, Vladimir Petrow
  • Patent number: 4096254
    Abstract: Compounds of the following general formula are useful in treating the symptoms of menopause and osteoporosis: ##STR1## wherein R is --CHO or --CH.sub.2 OR.sub.1 ; each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R.sub.3 is hydrogen; or R.sub.2 and R.sub.3 together form a double bond between the 17-position carbon atom and the oxygen atom.
    Type: Grant
    Filed: February 22, 1977
    Date of Patent: June 20, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Harvey D. Benson, Joyce Francis Grunwell, John O'Neal Johnston, Vladimir Petrow
  • Patent number: 4087524
    Abstract: Derivatives of androst-4-en-19-ol are described which are useful in enhancing the libido and related psychic attitudes in primates.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: May 2, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Joyce F. Grunwell, Vladimir Petrow
  • Patent number: 4078060
    Abstract: Compounds of the following general formula are useful in inducing an estrogenic response in a patient in need thereof: ##STR1## wherein R is --CHO or --CH.sub.2 OR.sub.1 ; each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R.sub.3 is hydrogen; or R.sub.2 and R.sub.3 together form a double bond between the 17-position carbon atom and the oxygen atom.
    Type: Grant
    Filed: May 10, 1976
    Date of Patent: March 7, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Harvey D. Benson, Joyce Francis Grunwell, John O'Neal Johnston, Vladimir Petrow
  • Patent number: 4078061
    Abstract: Compounds of the following general formula are useful in treating acne: ##STR1## wherein R is --CHO or --CH.sub.2 OR.sub.1 ; each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R.sub.3 is hydrogen; or R.sub.2 and R.sub.3 together form a double bond between the 17- position carbon atom and the oxygen atom.
    Type: Grant
    Filed: May 10, 1976
    Date of Patent: March 7, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Harvey D. Benson, Joyce Francis Grunwell, John O'Neal Johnston, Vladimir Petrow
  • Patent number: 4071624
    Abstract: The present invention concerns androst-4-en-19-ones which are useful in the enhancement of libido and related pyschic attitudes.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: January 31, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Joyce F. Grunwell, Vladimir Petrow
  • Patent number: 4071625
    Abstract: Derivatives of 19-oxygenated-5.alpha.-androstanes are described which are useful in enhancing the libido and related psychic attitudes in mammals.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: January 31, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Joyce F. Grunwell, Vladimir Petrow
  • Patent number: 4055641
    Abstract: Compounds of the following general formula are useful in treating benign prostatic hypertrophy: ##STR1## wherein R is --CHO or --CH.sub.2 OR.sub.1 ; each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R.sub.3 is hydrogen; or R.sub.2 and R.sub.3 together form a double bond between the 17-position carbon atom and the oxygen atom.
    Type: Grant
    Filed: May 10, 1976
    Date of Patent: October 25, 1977
    Assignee: Richardson-Merrell Inc.
    Inventors: Harvey D. Benson, Joyce Francis Grunwell, John O'Neal Johnston, Vladimir Petrow
  • Patent number: 4054651
    Abstract: A method of contraception which comprises administering a compound of the following general formula: ##STR1## wherein R is --CHO or --CH.sub.2 OR.sub.1 ; each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R.sub.3 is hydrogen; or R.sub.2 and R.sub.3 together form a double bond between the 17-position carbon atom and the oxygen atom either alone or in combination with a progestogen.
    Type: Grant
    Filed: May 10, 1976
    Date of Patent: October 18, 1977
    Assignee: Richardson-Merrell Inc.
    Inventors: Harvey D. Benson, Joyce Francis Grunwell, John O'Neal Johnston, Vladimir Petrow
  • Patent number: 4022769
    Abstract: The present invention concerns derivatives of androst-4-en-19-one which are useful in the enhancement of libido and related psychic attitudes.
    Type: Grant
    Filed: May 13, 1974
    Date of Patent: May 10, 1977
    Assignee: Richardson-Merrell Inc.
    Inventors: Joyce F. Grunwell, Vladimir Petrow
  • Patent number: 4013762
    Abstract: A method of promoting the growth of ruminants and poultry without concommitant adrogenizing effects using the following compound: ##STR1## wherein R is --CHO or --CH.sub.2 OR.sub.1 ; each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R.sub.3 is hydrogen; or R.sub.2 and R.sub.3 together form a double bond between the 17- position carbon atom and the oxygen atom.
    Type: Grant
    Filed: May 10, 1976
    Date of Patent: March 22, 1977
    Assignee: Richardson-Merrell Inc.
    Inventors: Harvey D. Benson, Joyce Francis Grunwell, John O'Neal Johnston, Vladimir Petrow
  • Patent number: 3988447
    Abstract: The invention relates to pharmaceutical preparation containing a 17a-acyloxy-6-methyl-16-methylene-pregna-4,6-diene-3,20-dione compound as an active ingredient, and to the use of such preparations for the palliative treatment and control of certain types of neoplasmin conditions.
    Type: Grant
    Filed: October 15, 1963
    Date of Patent: October 26, 1976
    Assignee: The British Drug Houses Ltd.
    Inventor: Vladimir Petrow