Patents by Inventor Vladimir Podust
Vladimir Podust has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240091315Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.Type: ApplicationFiled: March 13, 2023Publication date: March 21, 2024Inventors: Volker Schellenberger, Vladimir Podust, Chia-Wei Wang, Bryant McLaughlin, Bee-Cheng Sim, Sheng Ding, Chen Gu
-
Publication number: 20210322518Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.Type: ApplicationFiled: October 29, 2020Publication date: October 21, 2021Inventors: Volker Schellenberger, Vladimir Podust, Chia-Wei Wang, Bryant McLaughlin, Bee-Cheng Sim, Sheng Ding, Chen Gu
-
Publication number: 20210181207Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.Type: ApplicationFiled: December 14, 2020Publication date: June 17, 2021Applicants: ASPIRA WOMEN'S HEALTH INC., THE JOHNS HOPKINS UNIVERSITYInventors: ERIC THOMAS FUNG, ENRIQUE DALMASSO, VLADIMIR PODUST, ZHENG WANG, Zhen Zhang
-
Patent number: 10953073Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.Type: GrantFiled: September 17, 2018Date of Patent: March 23, 2021Assignee: Amunix Pharmaceuticals, Inc.Inventors: Volker Schellenberger, Vladimir Podust, Chia-Wei Wang, Bryant McLaughlin, Bee-Cheng Sim, Sheng Ding, Chen Gu
-
Publication number: 20200385469Abstract: The present invention relates to activatable recombinant polypeptide compositions comprising a cleavage release segment. In some instances, the activatable recombinant polypeptide compositions include an XTEN linked to binding moieties by cleavable release segments that, when cleaved, the binding moieties are capable of binding together effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable activatable recombinant compositions.Type: ApplicationFiled: December 20, 2018Publication date: December 10, 2020Inventors: Fan YANG, Volker SCHELLENBERGER, Vladimir PODUST, Bee-Cheng SIM, Desiree THAYER, John BEABER
-
Publication number: 20190083577Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.Type: ApplicationFiled: September 17, 2018Publication date: March 21, 2019Inventors: Volker Schellenberger, Vladimir Podust, Chia-Wei Wang, Bryant MCLAUGHLIN, Bee-Cheng Sim, Sheng Ding, Chen Gu
-
Patent number: 10172953Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.Type: GrantFiled: February 27, 2013Date of Patent: January 8, 2019Assignee: Amunix Operating Inc.Inventors: Volker Schellenberger, Vladimir Podust, Chia-Wei Wang, Bryant McLaughlin, Bee-Cheng Sim, Sheng Ding, Chen Gu
-
Publication number: 20150037359Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.Type: ApplicationFiled: February 27, 2013Publication date: February 5, 2015Applicant: AMUNIX OPERATING, INC.Inventors: Volker Schellenberger, Vladimir Podust, Chia-Wei Wang, Bryant McLaughlin, Bee-Cheng Sim, Sheng Ding, Chen Gu
-
Patent number: 8221984Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, it has been found that the biomarkers set forth in Table 1 are biomarkers for ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.Type: GrantFiled: March 27, 2008Date of Patent: July 17, 2012Assignees: Vermillion, Inc., Board of Regents, The University of Texas SystemInventors: Eric T. Fung, Robert Bast, Vladimir Podust, Charlotte Clarke
-
Publication number: 20120172356Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Chagas disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with Chagas disease or non-infected. The biomarkers can be detected by SELDI mass spectrometry.Type: ApplicationFiled: October 25, 2011Publication date: July 5, 2012Applicant: MCGILL UNIVERSITYInventors: Momar NDAO, Brian WARD, Hongshan LI, Vladimir PODUST, Rebecca CAFFREY, Terrance William SPITHILL, Regis PERICHON
-
Patent number: 8206934Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry, immunoassay, or other means.Type: GrantFiled: September 11, 2009Date of Patent: June 26, 2012Assignee: Vermillion, Inc.Inventors: Eric Thomas Fung, Tai-Tung Yip, Vladimir Podust, Mats Brannstrom, Karin Sundfeldt, Bjorg Kristjansdottir
-
Patent number: 8043825Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Chagas disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with Chagas disease or non-infected. The biomarkers can be detected by SELDI mass spectrometry.Type: GrantFiled: December 6, 2004Date of Patent: October 25, 2011Assignee: McGill UniversityInventors: Momar Ndao, Brian Ward, Rebecca Caffrey, Terence William Spithill, Hongshan Li, Vladimir Podust, Regis Perichon
-
Publication number: 20110129920Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's or non-Alzheimer's dementia or normal. The biomarkers can be detected by SELDI mass spectrometry. In addition, the invention provides appropriate treatment interventions and methods for measuring response to treatment. Certain biomarkers of the invention may also be suitable for employment as radio-labeled ligands in non-invasive imaging techniques such as Positron Emission Tomography (PET).Type: ApplicationFiled: July 28, 2010Publication date: June 2, 2011Applicant: Vermillion, Inc.Inventors: Huw Alun Davies, James McGuire, Anja Hviid Simonsen, Kaj Blennow, Vladimir Podust
-
Patent number: 7794948Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's or non-Alzheimer's dementia or normal. The biomarkers can be detected by SELDI mass spectrometry. In addition, the invention provides appropriate treatment interventions and methods for measuring response to treatment. Certain biomarkers of the invention may also be suitable for employment as radio-labeled ligands in non-invasive imaging techniques such as Positron Emission Tomography (PET).Type: GrantFiled: November 6, 2004Date of Patent: September 14, 2010Assignee: Vermilllion, Inc.Inventors: Huw Alun Davies, James McGuire, Anja Hviid Simonsen, Kaj Blennow, Vladimir Podust
-
Patent number: 7749716Abstract: The present invention provides a neurosecretory protein VGF peptide useful in qualifying Alzheimer's disease status in a patient. In particular, this peptide and modified forms thereof may be used to classify a subject sample as Alzheimer's disease or non-Alzheimer's disease. The peptide biomarker can be detected by SELDI mass spectrometry.Type: GrantFiled: June 13, 2006Date of Patent: July 6, 2010Assignee: Vermilllion, Inc.Inventors: Huw Alun Davies, Kaj Blennow, James McGuire, Vladimir Podust, Anja Hviid Simonsen
-
Publication number: 20100047847Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry, immunoassay, or other means.Type: ApplicationFiled: September 11, 2009Publication date: February 25, 2010Applicants: Vermillion, Inc., Sahlgrenska Academy at Goeteborg UniversityInventors: Eric T. Fung, Tai-Tung Yip, Vladimir Podust, Mats Brannstrom, Karin Sundfeldt, Bjorg Kristjansdottir
-
Publication number: 20090170208Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, it has been found that the biomarkers set forth in Table 1 are biomarkers for ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.Type: ApplicationFiled: March 27, 2008Publication date: July 2, 2009Applicants: Vermillion, Inc., The Board of Regents, The University of Texas SystemInventors: Eric T. Fung, Robert Bast, Vladimir Podust, Charlotte Clarke
-
Publication number: 20080274481Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry, immunoassay, or other means.Type: ApplicationFiled: March 27, 2008Publication date: November 6, 2008Applicants: Vermillion, Inc., Sahlgrenska Academy at Goeteborg UniversityInventors: Eric T. Fung, Tai-Tung Yip, Vladimir Podust, Mats Brannstrom, Karin Sundfeldt, Bjorg Kristjansdottir
-
Publication number: 20070015221Abstract: The present invention provides a neurosecretory protein VGF peptide useful in qualifying Alzheimer's disease status in a patient. In particular, this peptide and modified forms thereof may be used to classify a subject sample as Alzheimer's disease or non-Alzheimer's disease. The peptide biomarker can be detected by SELDI mass spectrometry.Type: ApplicationFiled: June 13, 2006Publication date: January 18, 2007Applicant: Ciphergen Biosystems, Inc.Inventors: Huw Davies, Kaj Blennow, James McGuire, Vladimir Podust, Anja Simonsen
-
Publication number: 20050260691Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Chagas disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with Chagas disease or non-infected. The biomarkers can be detected by SELDI mass spectrometry.Type: ApplicationFiled: December 6, 2004Publication date: November 24, 2005Applicant: Ciphergen Biosystems, Inc.Inventors: Momar Ndao, Brian Ward, Rebecca Caffrey, Terence Spithill, Hongshan Li, Vladimir Podust, Regis Perichon