Patents by Inventor Vladimir S. Trubetskoy

Vladimir S. Trubetskoy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of RNA function by delivery of inhibitors to animal cells
    Publication number: 20030143204
    Abstract: Described is a process for delivering an inhibitor directed against an expressible nucleic acid sequence in a mammal to inhibit RNA function. An RNA function inhibiting sequence that is specific to the expressible nucleic acid sequence in the mammal is made and inserted into a blood vessel in the mammal. The inhibitor is delivered to a cell wherein expression of the nucleic acid sequence is inhibited.
    Type: Application
    Filed: July 1, 2002
    Publication date: July 31, 2003
    Inventors: David L. Lewis, James E. Hagstrom, Hans Herweijer, Aaron G. Loomis, Sean D. Monahan, Vladimir S. Trubetskoy, Jon A. Wolff
  • Compositions and methods for drug delivery using pH sensitive molecules
    Publication number: 20030026841
    Abstract: An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
    Type: Application
    Filed: March 11, 2002
    Publication date: February 6, 2003
    Inventors: Vladimir S. Trubetskoy, James E. Hagstrom, Vladimir G. Budker, Jon A. Wolff, David B. Rozema, Sean D. Monahan
  • pH-titratable polyampholytes for delivering polyions to a cell
    Publication number: 20030008009
    Abstract: A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
    Type: Application
    Filed: March 11, 2002
    Publication date: January 9, 2003
    Inventors: Vladimir S. Trubetskoy, James E. Hagstrom, Vladimir G. Budker, Jon A. Wolff, David B. Rozema, Sean D. Monahan
  • Methods for genetic immunization
    Publication number: 20020165183
    Abstract: The present invention relates to methods for delivering a genetic immunogen, comprising a nucleic acid capable of expressing an antigen, optionally complexed with a polymer. The nucleic acid is delivered to the host via an intravascular, oral, buccal, dermal, nasal, or rectal route, where the complex transfects lymphoid tissues resulting in expression of an encoded antigen and induction of an antigen-specific immune response.
    Type: Application
    Filed: November 13, 2001
    Publication date: November 7, 2002
    Inventors: Hans Herweijer, Jon A. Wolff, Aaron G. Loomis, Vladimir S. Trubetskoy, Mary Kay Bates
  • Polyampholytes for delivering polyions to a cell
    Publication number: 20020164315
    Abstract: An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
    Type: Application
    Filed: May 10, 2002
    Publication date: November 7, 2002
    Inventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy
  • Process of making a compound by forming a polymer from a template drug
    Publication number: 20020165184
    Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
    Type: Application
    Filed: November 16, 2001
    Publication date: November 7, 2002
    Inventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy, Paul M. Slattum, Lisa J. Hanson
  • Formation of polyampholytes in the presence of a polyion
    Publication number: 20020160515
    Abstract: A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
    Type: Application
    Filed: March 11, 2002
    Publication date: October 31, 2002
    Inventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy
  • Process of making a compound by forming a polymer from a template drug
    Publication number: 20020085989
    Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
    Type: Application
    Filed: December 5, 2001
    Publication date: July 4, 2002
    Inventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy, Paul M. Slattum, Lisa J. Hanson
  • Process of making a compound by forming a polymer from a template drug
    Publication number: 20020061287
    Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
    Type: Application
    Filed: December 5, 2001
    Publication date: May 23, 2002
    Inventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy, Paul M. Slattum, Lisa J. Hanson
  • Polyampholytes for delivering polyions to a cell
    Patent number: 6383811
    Abstract: An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
    Type: Grant
    Filed: January 2, 2001
    Date of Patent: May 7, 2002
    Assignee: Mirus Corporation
    Inventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy
  • Process of making a compound by forming a polymer from a template drug
    Patent number: 6339067
    Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
    Type: Grant
    Filed: December 30, 1997
    Date of Patent: January 15, 2002
    Assignee: Mirus Corporation
    Inventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy, Paul M. Slattum, Lisa J. Hanson
  • Polyampholytes for delivering polyions to a cell
    Publication number: 20010024829
    Abstract: An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
    Type: Application
    Filed: January 2, 2001
    Publication date: September 27, 2001
    Inventors: Jon A. Wolff, James E. Hagstrom, Vladimir S. Trubetskoy, Vladimir G. Budker
  • Chelating polymers for labeling of proteins
    Patent number: 6203775
    Abstract: A method of labelling a protein with a metal involving chelating a metal to a compound, with a molecular weight of at least 1,000, and a reactive group capable of forming a covalent bond with a target protein, and conjugating the metallically-labelled compound to a protein.
    Type: Grant
    Filed: March 19, 1993
    Date of Patent: March 20, 2001
    Assignee: The General Hospital Corporation
    Inventors: Vladimir P. Torchilin, Vladimir S. Trubetskoy
  • Process of making a compound by forming a polymer from a template drug
    Patent number: 6126964
    Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
    Type: Grant
    Filed: January 3, 1997
    Date of Patent: October 3, 2000
    Assignee: Mirus Corporation
    Inventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy, Paul M. Slattum, Lisa J. Hanson
  • Amphipathic polychelating compounds and method of use
    Patent number: 5756069
    Abstract: An amphipathic polychelating compound including a hydrophilic polymeric moiety having a main backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of the polymeric moiety, and a plurality of chelating agents linked to the side groups of the polymeric moiety. The polychelating compounds are bound to liposomes or micelles for use as diagnostic and therapeutic agents.
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: May 26, 1998
    Inventors: Vladimir P. Torchilin, Vladimir S. Trubetskoy, Gerald L. Wolf
  • Targeted co-polymers for radiographic imaging
    Patent number: 5746998
    Abstract: A radiographic imaging agent including a plurality of block copolymers forming a micelle, the block copolymers including a hydrophilic polymer linked to a hydrophobic polymer, and the hydrophobic polymer including a backbone incorporating radiopaque molecules via covalent bonds.
    Type: Grant
    Filed: August 8, 1996
    Date of Patent: May 5, 1998
    Assignee: The General Hospital Corporation
    Inventors: Vladimir P. Torchilin, Vladimir S. Trubetskoy, Gerald L. Wolf, G. Scott Gazelle
  • Composotions and methods for radiographic imaging
    Patent number: 5567410
    Abstract: A radiographic imaging agent including a plurality of block copolymers forming a micelle, the block copolymers including a hydrophilic polymer linked to a hydrophobic polymer, and the hydrophobic polymer including a backbone incorporating radiopaque molecules via covalent bonds.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: October 22, 1996
    Assignee: The General Hospital Corporation
    Inventors: Vladimir P. Torchilin, Vladimir S. Trubetskoy, Gerald L. Wolf, G. Scott Gazelle
  • Amphipathic polychelating compounds and methods of use
    Patent number: 5534241
    Abstract: An amphipathic polychelating compound including a hydrophilic polymeric moiety having a main backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of the polymeric moiety, and a plurality of chelating agents linked to the side groups of the polymeric moiety. The polychelating compounds are bound to liposomes or micelles for use as diagnostic and therapeutic agents.
    Type: Grant
    Filed: July 23, 1993
    Date of Patent: July 9, 1996
    Inventors: Vladimir P. Torchilin, Vladimir S. Trubetskoy, Gerald L. Wolf