Abstract: Modular, miniaturized cardiovascular sensors, systems, methods, and wearable devices for the non-obtrusive evaluation, monitoring, and high-fidelity mapping of cardiac mechanical and electromechanical forces and central arterial blood pressure are presented herein. The sensor manufacturing process is also presented. Using accelerometers, the sensors register body-surface (preferably torso-surface) movements and vibrations generated by cardiac forces. The sensors may contain single-use or reusable components, which may be exchanged to fit different body sizes, shapes, and anatomical locations; they may be incorporated into clothing, bands, straps, and other wearable arrangements. The invention presents a practical, noninvasive solution for electromechanical mapping of the heart, which is useful for a wide range of healthcare applications, including the remote monitoring of heart failure status and the guidance of cardiac resynchronization therapy.

Abstract: A system and method adapted for at least one health-related application selected from physiological monitoring, defibrillation, and pacing in the presence of electromagnetic interference (EMI) using the time-domain features of EMI patterns and physiological waveforms. The invention enables EMI detection and identification in a plurality of signals, including various physiological signals, which may contain both physiological information and EMI-generated artifacts. The system utilizes adaptive and versatile modular architecture with a set of modules for various filtering, conditioning, processing, and wireless transmission functions, which can be assembled in different configurations for different settings. In some preferred embodiments, the method and system of this invention are incorporated into (or attached to) an external cardiac defibrillator/monitor or cardiac pacing device.

Abstract: Method and system for evaluating arterial pressure waves, vascular properties, as well as for diagnostic, physiological and pharmacological testing using various combinations of the following data acquisition and processing steps (some of the steps are optional): 1. Perturbing arterial pressure from its steady state. 2. Measuring the dynamics of at least one parameter related to the passage of arterial pressure waves along blood vessels. 3. Characterizing the magnitude and functional relation of changes in parameters described above in relation to changes in blood pressure during its displacement from and/or return to the steady state. 4. Classifying (comparing) the individual functional relation described above with a databank of parameters/functional relations for different states of vasomotor activity.

Abstract: This accessory adapts external cardiac defibrillation systems to enable safe defibrillation, pacing, and cardioversion inside the MRI bore with minimal effect on MR image quality. Commercially available external defibrillators are not designed to work in the MRI environment. An MR-compatible defibrillator is needed to safely perform cardiovascular MRI, in particular MR-guided interventional cardiovascular procedures, such as cardiac electrophysiology studies and cardiac catheterization. This accessory includes nonmagnetic defibrillator housing with MRI safety features, provides interface for MRI-compatible physiological monitoring, and optimizes defibrillator operation for the MRI environment. The accessory may include MRI-compatible modules for monitoring/recording electrocardiogram, blood pressure, pulse oximetry, and other physiological signals. It may also include a wireless transmitter and at least one module for electrical energy generation and/or stimulation.

Abstract: A wireless monitoring system that provides reliable wireless data transmission during patient table (bed) movement. The system makes use of at least one wireless antenna linked to the patient table to provide substantially continuous, unobstructed communication regardless of the patient table's position and the movement of medical personnel around the table. The system also utilizes adaptive filtering of electromagnetic interference, signal conditioning, and detection of cardiac-activity waveforms, providing means for adjusting signal-processing parameters to the specific features of electromagnetic interference and cardiac waveforms.

Abstract: A system and method adapted for at least one health-related application selected from physiological monitoring, defibrillation, and pacing in the presence of electromagnetic interference (EMI) using the time-domain features of EMI patterns and physiological waveforms. The invention enables EMI detection and identification in a plurality of signals, including various physiological signals, which may contain both physiological information and EMI-generated artifacts. The system utilizes adaptive and versatile modular architecture with a set of modules for various filtering, conditioning, processing, and wireless transmission functions, which can be assembled in different configurations for different settings. In some preferred embodiments, the method and system of this invention are incorporated into (or attached to) an external cardiac defibrillator/monitor or cardiac pacing device.

Abstract: This accessory adapts external cardiac defibrillation systems to enable safe defibrillation, pacing, and cardioversion inside the MRI bore with minimal effect on MR image quality. Commercially available external defibrillators are not designed to work in the MRI environment. An MR-compatible defibrillator is needed to safely perform cardiovascular MRI, in particular MR-guided interventional cardiovascular procedures, such as cardiac electrophysiology studies and cardiac catheterization. This accessory includes nonmagnetic defibrillator housing with MRI safety features, provides interface for MRI-compatible physiological monitoring, and optimizes defibrillator operation for the MRI environment. The accessory may include MRI-compatible modules for monitoring/recording electrocardiogram, blood pressure, pulse oximetry, and other physiological signals. It may also include a wireless transmitter and at least one module for electrical energy generation and/or stimulation.

Abstract: Apparatus and methods for dynamical tracking of movement of cells and cell groups within cell populations using magnetic resonance imaging are provided.

Abstract: Method and system for evaluating arterial pressure waves, vascular properties, as well as for diagnostic, physiological and pharmacological testing using various combinations of the following data acquisition and processing steps (some of the steps are optional): 1. Perturbing arterial pressure from its steady state. 2. Measuring the dynamics of at least one parameter related to the passage of arterial pressure waves along blood vessels. 3. Characterizing the magnitude and functional relation of changes in parameters described above in relation to changes in blood pressure during its displacement from and/or return to the steady state. 4. Classifying (comparing) the individual functional relation described above with a databank of parameters/functional relations for different states of vasomotor activity.

Abstract: Modular, miniaturized cardiovascular sensors, systems, methods, and wearable devices for the non-obtrusive evaluation, monitoring, and high-fidelity mapping of cardiac mechanical and electromechanical forces and central arterial blood pressure are presented herein. The sensor manufacturing process is also presented. Using accelerometers, the sensors register body-surface (preferably torso-surface) movements and vibrations generated by cardiac forces. The sensors may contain single-use or reusable components, which may be exchanged to fit different body sizes, shapes, and anatomical locations; they may be incorporated into clothing, bands, straps, and other wearable arrangements. The invention presents a practical, noninvasive solution for electromechanical mapping of the heart, which is useful for a wide range of healthcare applications, including the remote monitoring of heart failure status and the guidance of cardiac resynchronization therapy.

Abstract: Method and system for evaluating arterial pressure waves, vascular properties, as well as for diagnostic, physiological and pharmacological testing using various combinations of the following data acquisition and processing steps (some of the steps are optional): 1. Perturbing arterial pressure from its steady state. 2. Measuring the dynamics of at least one parameter related to the passage of arterial pressure waves along blood vessels. 3. Characterizing the magnitude and functional relation of changes in parameters described above in relation to changes in blood pressure during its displacement from and/or return to the steady state. 4. Classifying (comparing) the individual functional relation described above with a databank of parameters/functional relations for different states of vasomotor activity.

Abstract: A wireless monitoring system that provides reliable wireless data transmission during patient table (bed) movement. The system makes use of at least one wireless antenna linked to the patient table to provide substantially continuous, unobstructed communication regardless of the patient table's position and the movement of medical personnel around the table. The system also utilizes adaptive filtering of electromagnetic interference, signal conditioning, and detection of cardiac-activity waveforms, providing means for adjusting signal-processing parameters to the specific features of electromagnetic interference and cardiac waveforms.

Abstract: This multipurpose, modular system provides diagnostic-quality, wireless, multichannel monitoring in diverse settings, including interventional procedures guided by X-ray and MRI, with variable electromagnetic interference (EMI) and eliminates the need for multiple detachments/reattachments of patient cables when the patient is moved from one room/procedure to another. The system includes: 1) multiple filterbanks (filtering procedures) for recording both diagnostic-quality (broad-band) signals in the absence of EMI and narrow-band signals in the presence of EMI, with subsequent reconstruction of diagnostic-quality signals from the narrow-band signals; 2) filtering of EMI, using a priori and adaptive criteria about differences between the EMI and physiological signals' characteristics; 3) filtering of the magneto-hydrodynamic effect, using physiological measurements at different distances from the magnet (i.e.

Abstract: Apparatus and methods for dynamical tracking of movement of cells and cell groups within cell populations using magnetic resonance imaging are provided.

Abstract: This multipurpose, modular system provides diagnostic-quality, wireless, multichannel monitoring in diverse settings, including interventional procedures guided by X-ray and MRI, with variable electromagnetic interference (EMI) and eliminates the need for multiple detachments/reattachments of patient cables when the patient is moved from one room/procedure to another. The system includes: 1) multiple filterbanks (filtering procedures) for recording both diagnostic-quality (broad-band) signals in the absence of EMI and narrow-band signals in the presence of EMI, with subsequent reconstruction of diagnostic-quality signals from the narrow-band signals; 2) filtering of EMI, using a priori and adaptive criteria about differences between the EMI and physiological signals' characteristics; 3) filtering of the magneto-hydrodynamic effect, using physiological measurements at different distances from the magnet (i.e.

Abstract: Adaptive system for medical monitoring distributes data processing among computing devices connected to a network to optimize usage of computational resources, network communication speed and user experience. Data processing is distributed into several levels with bi-directional communication between the levels (computing devices) to coordinate and adjust data compression, filtering, and analysis, as well as the size of buffered data available for transmission and/or receiving.

Abstract: Method and system for noncontact electrophysiologic imaging of the heart. The methods may employ the magnetization and its relaxation-based measurements, sensitive or specifically sensitized to the properties of cardiac electrical activity, to determine the spatio-temporal distribution of cardiac electromagnetic field and cardiac electrical potentials, and to display such spatio-temporal distribution (image) for assisting in the identification of the regions with abnormal cardiac electrical activity. In one embodiment, the system uses external magnets, gradient magnetic fields and radio-frequency waves, such as those commonly used for MRI, to generate the magnetic resonance. The system synchronizes scanning to the cardiac cycle using a measure of cardiac activity (e.g.

Abstract: Method and system for evaluating arterial pressure waves, vascular properties, as well as for diagnostic, physiological and pharmacological testing using various combinations of the following data acquisition and processing steps (some of the steps are optional): 1. Perturbing arterial pressure from its steady state. 2. Measuring the dynamics of at least one parameter related to the passage of arterial pressure waves along blood vessels. 3. Characterizing the magnitude and functional relation of changes in parameters described above in relation to changes in blood pressure during its displacement from and/or return to the steady state. 4. Classifying (comparing) the individual functional relation described above with a databank of parameters/functional relations for different states of vasomotor activity.

Abstract: Method and system for the analysis and source localization of the dynamical patterns in medical and health data, and linking such dynamical patterns with the individual's genetic and/or molecular data. The invention makes use of optimally positioned sensors (sensor arrays) providing input data for signal processing, time-series analysis, pattern recognition and mathematical modeling to facilitate dynamical tracking of systemic arterial pressure without a pressure cuff, local vascular activity, electrocardiographic (ECG), respiratory, physical, muscular, gastrointestinal and neural activity, temperature and other physiological/health data. The invention also facilitates separation of local signals (such as local aneurisms or local vascular activity) from non-local, central or systemic patterns (e.g. systemic blood pressure).

Abstract: Adaptive system for medical monitoring distributes data processing among computing devices connected to a network to optimize usage of computational resources, network communication speed and user experience. Data processing is distributed into several levels with bi-directional communication between the levels (computing devices) to coordinate and adjust data compression, filtering, and analysis, as well as the size of buffered data available for transmission and/or receiving.