Patents by Inventor Vladimir Subbotin

Vladimir Subbotin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Delivery of molecules and complexes to mammalian cells in vivo
    Patent number: 7589059
    Abstract: Disclosed is a system for providing in vivo delivery of molecules or complexes to extravascular mammalian cells using an intravascular administration route. The molecules or complexes are inserted in an injection solution into a mammalian vasculature. Insertion of the injection solution at an appropriate rate transiently increases the volume of extravascular fluid in the tissue thereby facilitating delivery of the molecule to the cell.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: September 15, 2009
    Assignee: Roche Madison Inc.
    Inventors: Jon A. Wolff, Vladimir G. Budker, Hans Herweijer, James E. Hagstrom, Sean D. Monahan, Julia Hegge, Vladimir Subbotin
  • Reversible Hydrophobic Modification of Drugs for Improved Delivery to Cells
    Publication number: 20090074885
    Abstract: Described are drug formulations that increase regional delivery of the drugs to cells. Methods for reversibly increasing the hydrophobicity of a drug through hydrolytically labile attachment of a hydrophobic moiety and methods for delivering the modified drug to cells are described. Hydrophobic modification increases drug delivery, while lability minimizes entry of the drug into non-target cells.
    Type: Application
    Filed: October 29, 2008
    Publication date: March 19, 2009
    Applicant: Roche Madison Inc.
    Inventors: Sean D. Monahan, Vladimir Subbotin, Zane C. Neal, Vladimir G. Budker, Tatyana Budker
  • Devices and processes for distribution of genetic material to mammalian limb
    Patent number: 7214369
    Abstract: A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from ischemia. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution is enhanced by combining injection of a solution containing the polynucleotide with the use of an externally applied cuff.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: May 8, 2007
    Assignee: Mirus Bio Corporation
    Inventors: Jon A. Wolff, Vladimir G. Budker, James E. Hagstrom, Julia Hegge, Vladimir Subbotin
  • Direct DNA delivery to bone cells
    Publication number: 20060115462
    Abstract: An method is described that enables in vivo delivery of polynucleotides to cells of a mammalian bone limb. The method involves the injection of polynucleotides in a large volume into the lumen of the bone.
    Type: Application
    Filed: November 23, 2005
    Publication date: June 1, 2006
    Inventors: Vladimir Subbotin, Julia Hegge
  • Delivery by labile hydrophobic modification of drugs
    Publication number: 20050054612
    Abstract: Described are drug formulations that increase regional delivery of the drugs to cells. Methods for reversibly increasing the hydrophobicity of a drug through hydrolytic ally labile attachment of a hydrophobic moiety and methods for delivering the modified drug to cells is described. Hydrophobic modification increases drug delivery, while lability minimizes entry of the drug into non-target cells.
    Type: Application
    Filed: August 30, 2004
    Publication date: March 10, 2005
    Inventors: Sean Monahan, Vladimir Budker, Zane Neal, Vladimir Subbotin
  • Devices and processes for distribution of genetic material to mammalian limb
    Publication number: 20040224879
    Abstract: A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from ischemia. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution is enhanced by combining injection of a solution containing the polynucleotide with the use of an externally applied cuff.
    Type: Application
    Filed: May 5, 2003
    Publication date: November 11, 2004
    Inventors: Jon A. Wolff, Vladimir G. Budker, James E. Hagstrom, Julia Hegge, Vladimir Subbotin
  • Covalent modification of RNA for in vitro and in vivo delivery
    Publication number: 20040167090
    Abstract: The post-synthetic modification of RNA for the delivery of the RNA to a mammalian cell is described. The modifications enhance resistant of the RNA to nuclease digestion and delivery of the RNA to the cell whether the RNA is delivered alone or in combination with a transfection agent. Activity of the RNA in the cell is maintained.
    Type: Application
    Filed: February 19, 2004
    Publication date: August 26, 2004
    Inventors: Sean D. Monahan, Vladimir G. Budker, Lisa Nader, Vladimir Subbotin, Jon A. Wolff
  • Delivery of molecules and complexes to mammalian cells in vivo
    Publication number: 20040023850
    Abstract: Disclosed is a system for providing in vivo delivery of molecules or complexes to extravascular mammalian cells using an intravascular administration route. The molecules or complexes are inserted in an injection solution into a mammalian vasculature. Insertion of the injection solution at an appropriate rate transiently increases the volume of extravascular fluid in the tissue thereby facilitating delivery of the molecule to the cell.
    Type: Application
    Filed: July 28, 2003
    Publication date: February 5, 2004
    Inventors: Jon A. Wolff, Vladimir G. Budker, Hans Herweijer, James E. Hagstrom, Sean D. Monahan, Julia Hegge, Vladimir Subbotin
  • Device and methods for bile duct access and targeted delivery of fluid to liver and pancreas
    Publication number: 20030229318
    Abstract: A device for bile duct access and targeted delivery of fluid to the liver and pancreas and methods of use are described. The device allows improved delivery of fluid without causing damage the bile duct or surrounding tissues.
    Type: Application
    Filed: June 6, 2003
    Publication date: December 11, 2003
    Inventor: Vladimir Subbotin