Patents by Inventor Vladimir V. Martin

Vladimir V. Martin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heavy Metal Binding Compounds and Their Method of Use
    Publication number: 20100167333
    Abstract: The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of heavy metal ions in a sample.
    Type: Application
    Filed: December 11, 2009
    Publication date: July 1, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Kyle R. Gee, Jolene Bradford, Vladimir V. Martin
  • CROWN ETHER DERIVATIVES
    Publication number: 20100047821
    Abstract: The invention describes crown ether chelators, including crown ethers having the formula:
    Type: Application
    Filed: August 24, 2009
    Publication date: February 25, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Kyle R. Gee, Vladimir V. Martin
  • Crown ether derivatives
    Patent number: 7579463
    Abstract: The invention describes crown ether chelators, including crown ethers having the formula:
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: August 25, 2009
    Assignee: Life Technologies Corporation
    Inventors: Kyle R. Gee, Vladimir V. Martin
  • Heavy metal binding compounds and their method of use
    Patent number: 7521577
    Abstract: The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of heavy metal ions in a sample.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: April 21, 2009
    Assignee: Molecular Probes, Inc.
    Inventors: Kyle R. Gee, Jolene Bradford, Vladimir V. Martin
  • Compositions and methods for detection and isolation of phosphorylated molecules
    Patent number: 7445894
    Abstract: The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and a metal ion wherein the metal ion simultaneously interacts with an exposed phosphate group on a target molecule and the metal chelating moiety of the phosphate-binding compound forming a bridge between the phosphate-binding compound and a phosphorylated target molecule resulting in a ternary complex. The binding solution of the present invention finds use in binding and detecting immobilized and solubilized phosphorylated target molecules, isolation of phosphorylated target molecules from a complex mixture and aiding in proteomic analysis wherein kinase and phosphatase substrates and enzymes can be identified.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: November 4, 2008
    Assignee: Molecular Probes, Inc.
    Inventors: Brian Agnew, Kyle R. Gee, Vladimir V. Martin
  • Crown ether derivatives
    Patent number: 7129346
    Abstract: The invention describes crown ether chelators, including crown ethers having the formula and aza-substituted and thia-substituted analogs thereof. These crown ethers may be substituted by a dye moiety, a chemically reactive group, a conjugated substance, or a combination thereof. Chelators that are substituted by fluorescent dyes are particularly useful as indicators for metal cations, particularly Na+ and K+ ions, and particularly where binding of the target ion results in a change in the fluorescence properties of the indicator that can be correlated with the ion concentration. Methods are provided for utilizing reactive groups on the chelators for conjugation to dyes, lipids and polymers and methods for enhancing entry of the indicators into living cells.
    Type: Grant
    Filed: August 4, 2003
    Date of Patent: October 31, 2006
    Assignee: Molecular Probes, Inc.
    Inventors: Kyle R. Gee, Vladimir V. Martin
  • Crown ether derivatives
    Patent number: 6962992
    Abstract: The invention describes crown ether chelators, including crown ethers having the formula and aza-substituted and thia-substituted analogs thereof. These crown ethers are substituted by a dye moiety, a chemically reactive group, a conjugated substance, or a combination thereof. Chelators that are substituted by fluorescent dyes are particularly useful as indicators for metal cations, particularly Na+ and K+ ions, and particularly where binding of the target ion results in a change in the fluorescence properties of the indicator that can be correlated with the ion concentration. Methods are provided for utilizing reactive groups on the chelators for conjugation to dyes, lipids and polymers and methods for enhancing entry of the indicators into living cells.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: November 8, 2005
    Assignee: Molecullar Probes, Inc.
    Inventors: Vladimir V. Martin, Kyle R. Gee, Richard P. Haugland, Zhenjun Diwu
  • Crown ether derivatives
    Publication number: 20040096978
    Abstract: The invention describes crown ether chelators, including crown ethers having the formula 1
    Type: Application
    Filed: August 4, 2003
    Publication date: May 20, 2004
    Inventors: Vladimir V. Martin, Kyle Gee
  • Crown ether derivatives
    Publication number: 20020164616
    Abstract: The invention describes crown ether chelators, including crown ethers having the formula 1
    Type: Application
    Filed: December 19, 2001
    Publication date: November 7, 2002
    Applicant: Molecular Probes, Inc.
    Inventors: Vladimir V. Martin, Kyle R. Gee, Richard P. Haugland, Zhenjun Diwu