Patents by Inventor Vladimir Voynov

Vladimir Voynov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BINDING MOLECULES FOR THE TREATMENT OF CANCER
    Publication number: 20240150480
    Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.
    Type: Application
    Filed: November 14, 2023
    Publication date: May 9, 2024
    Inventors: Klaus-Peter KUENKELE, Timothy FENN, Juan Manuel GARCIA-MARTINEZ, Jason HO, Christian KOESSL, Saurabh SEN, Vladimir VOYNOV, Andreas WERNITZNIG, Ertan ERYILMAZ, Rajkumar GANESAN, Abdulsalam SHAABAN
  • TRAILR2 CDH17 binding molecules for the treatment of cancer
    Patent number: 11851495
    Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: December 26, 2023
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Klaus-Peter Kuenkele, Timothy Fenn, Juan Manuel Garcia-Martinez, Jason Ho, Christian Koessl, Saurabh Sen, Vladimir Voynov, Andreas Wernitznig
  • BINDING MOLECULES FOR THE TREATMENT OF CANCER
    Publication number: 20210095038
    Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.
    Type: Application
    Filed: October 30, 2020
    Publication date: April 1, 2021
    Inventors: Klaus-Peter KUENKELE, Timothy FENN, Juan Manuel GARCIA-MARTINEZ, Jason HO, Christian KOESSL, Saurabh SEN, Vladimir VOYNOV, Andreas WERNITZNIG, Ertan ERYILMAZ, Rajkumar GANESAN, Abdulsalam SHAABAN
  • TRAILR2 CDH17 binding molecules for the treatment of cancer
    Patent number: 10858438
    Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: December 8, 2020
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Klaus-Peter Kuenkele, Timothy Fenn, Juan Manuel Garcia-Martinez, Jason Ho, Christian Koessl, Saurabh Sen, Vladimir Voynov, Andreas Wernitznig
  • Anti-TrkB antibodies
    Patent number: 10793634
    Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: October 6, 2020
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Rolf Herrmann, Remko Alexander Bakker, Sebastian Bandholtz, Peter Michael Benz, Michael Dziegelewski, Lore Florin, Cynthia Hess Kenny, Sarah Low, Holger Rosenbrock, Sanjaya Singh, Heiko Friedrich Stahl, Sathyadevi Venkataramani, Vladimir Voynov, Haiguang Xiao
  • ANTI-TRKB ANTIBODIES
    Publication number: 20180355046
    Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.
    Type: Application
    Filed: June 7, 2018
    Publication date: December 13, 2018
    Inventors: Rolf Herrmann, Remko Alexander Bakker, Sebastian Bandholtz, Peter Michael Benz, Michael Dziegelewski, Lore Florin, Cynthia Hess Kenny, Sarah Low, Holger Rosenbrock, Sanjaya Singh, Heiko Friedrich Stahl, Sathyadevi Venkataramani, Vladimir Voynov, Haiguang Xiao
  • BINDING MOLECULES FOR THE TREATMENT OF CANCER
    Publication number: 20180179287
    Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.
    Type: Application
    Filed: December 21, 2017
    Publication date: June 28, 2018
    Inventors: Klaus-Peter KUENKELE, Timothy FENN, Juan Manuel GARCIA-MARTINEZ, Jason HO, Christian KOESSL, Saurabh SEN, Vladimir VOYNOV, Andreas WERNITZNIG
  • Methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
    Patent number: 9922164
    Abstract: The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: March 20, 2018
    Assignees: Novartis AG, Massachusetts Institute of Technology
    Inventors: Naresh Chennamsetty, Bernhard Helk, Bernhardt Trout, Veysel Kayser, Vladimir Voynov
  • IMMUNOGLOBULINS WITH REDUCED AGGREGATION
    Publication number: 20170349650
    Abstract: The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such immunoglobulins particularly in the treatment and prevention of disease.
    Type: Application
    Filed: May 16, 2017
    Publication date: December 7, 2017
    Applicants: Novartis AG, Massachusetts Institute of Technology
    Inventors: Naresh CHENNAMSETTY, Bernhard HELK, Veysel KAYSER, Bernhardt TROUT, Vladimir VOYNOV
  • METHODS FOR IDENTIFICATION OF SITES FOR IGG CONJUGATION
    Publication number: 20170198007
    Abstract: The present disclosure relates to immunoglobulins and immunoglobulin conjugates with reduced oligomerization and efficient labeling and compositions, methods of generating such immunoglobulins and immunoglobulin conjugates and methods of using such immunoglobulin conjugates particularly in the treatment and prevention of disease.
    Type: Application
    Filed: March 27, 2017
    Publication date: July 13, 2017
    Applicants: Novartis AG, Massachusetts Institute of Technology
    Inventors: Naresh CHENNAMSETTY, Bernhard HELK, Veysel KAYSER, Bernhardt TROUT, Vladimir VOYNOV
  • Immunoglobulins with reduced aggregation
    Patent number: 9676841
    Abstract: The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such immunoglobulins particularly in the treatment and prevention of disease.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: June 13, 2017
    Assignees: Novartis AG, Massachusetts Institute of Technology
    Inventors: Naresh Chennamsetty, Bernhard Helk, Veysel Kayser, Bernhardt Trout, Vladimir Voynov
  • Methods for identification of sites for IgG conjugation
    Patent number: 9629925
    Abstract: The present disclosure relates to immunoglobulins and immunoglobulin conjugates with reduced oligomerization and efficient labeling and compositions, methods of generating such immunoglobulins and immunoglobulin conjugates and methods of using such immunoglobulin conjugates particularly in the treatment and prevention of disease.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: April 25, 2017
    Assignees: Novartis AG, Massachusetts Institute of Technology
    Inventors: Naresh Chennamsetty, Bernhard Helk, Veysel Kayser, Bernhardt Trout, Vladimir Voynov
  • METHODS TO IDENTIFY MACROMOLECULE BINDING AND AGGREGATION PRONE REGIONS IN PROTEINS AND USES THEREFOR
    Publication number: 20160364521
    Abstract: The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.
    Type: Application
    Filed: August 26, 2016
    Publication date: December 15, 2016
    Applicants: Novartis AG, Massachusetts Institute of Technology
    Inventors: Naresh CHENNAMSETTY, Bernhard HELK, Bernhardt TROUT, Veysel KAYSER, Vladimir VOYNOV
  • METHODS FOR IDENTIFICATION OF SITES FOR IGG CONJUGATION
    Publication number: 20150056220
    Abstract: The present disclosure relates to immunoglobulins and immunoglobulin conjugates with reduced oligomerization and efficient labeling and compositions, methods of generating such immunoglobulins and immunoglobulin conjugates and methods of using such immunoglobulin conjugates particularly in the treatment and prevention of disease.
    Type: Application
    Filed: August 1, 2014
    Publication date: February 26, 2015
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, NOVARTIS AG
    Inventors: Naresh CHENNAMSETTY, Bernhard HELK, Veysel KAYSER, Bernhardt TROUT, Vladimir VOYNOV
  • IMMUNOGLOBULINS WITH REDUCED AGGREGATION
    Publication number: 20140348820
    Abstract: The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such immunoglobulins particularly in the treatment and prevention of disease.
    Type: Application
    Filed: April 29, 2014
    Publication date: November 27, 2014
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, NOVARTIS AG
    Inventors: Naresh CHENNAMSETTY, Bernhard HELK, Veysel KAYSER, Bernhardt TROUT, Vladimir VOYNOV
  • Methods for identification of sites for IgG conjugation
    Patent number: 8834885
    Abstract: The present disclosure relates to immunoglobulins and immunoglobulin conjugates with reduced oligomerization and efficient labeling and compositions, methods of generating such immunoglobulins and immunoglobulin conjugates and methods of using such immunoglobulin conjugates particularly in the treatment and prevention of disease.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: September 16, 2014
    Assignees: Novartis AG, Massachusetts Institute of Technology
    Inventors: Naresh Chennamsetty, Bernhard Helk, Veysel Kayser, Bernhardt Trout, Vladimir Voynov
  • Immunoglobulins with reduced aggregation
    Patent number: 8747848
    Abstract: The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such immunoglobulins particularly in the treatment and prevention of disease.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: June 10, 2014
    Assignees: Novartis AG, Massachusetts Institute of Technology
    Inventors: Naresh Chennamsetty, Bernhard Helk, Veysel Kayser, Bernhardt Trout, Vladimir Voynov
  • IMMUNOGLOBULINS WITH REDUCED AGGREGATION
    Publication number: 20120003211
    Abstract: The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such immunoglobulins particularly in the treatment and prevention of disease.
    Type: Application
    Filed: June 19, 2009
    Publication date: January 5, 2012
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, NOVARTIS AG
    Inventors: Naresh Chennamsetty, Bernhard Helk, Veysel Kayser, Bernhardt Trout, Vladimir Voynov
  • METHODS TO IDENTIFY MACROMOLECULE BINDING AND AGGREGATION PRONE REGIONS IN PROTEINS AND USES THEREFOR
    Publication number: 20110257104
    Abstract: The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.
    Type: Application
    Filed: June 19, 2009
    Publication date: October 20, 2011
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, NOVARTIS AG
    Inventors: Naresh Chennamsetty, Bernhard Helk, Bernhardt Trout, Veysel Kayser, Vladimir Voynov