Abstract: Described herein are liposomes that can be capable of targeting within blood vessels to an intended tissue area presenting at least one vascular inflammatory marker and enhancing imaging contrast therein. Described herein are aspects of a targeting liposome that can carry antibodies against at least one vascular inflammatory marker and a contrast agent to an intended tissue area presenting the at least one vascular inflammatory marker whereby the liposomes can be capable of anchoring to the intended vascular inflammation site and enhancing imaging contrast of it. Also described herein are methods of using the targeting liposomes for anchoring the liposomes to vascular inflammation and imaging vascular inflammation.