Patents by Inventor Vladimir ZARNITSYN
Vladimir ZARNITSYN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230157869Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: January 19, 2023Publication date: May 25, 2023Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor ANDINO, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Patent number: 11596545Abstract: Devices, methods, and kits for ocular drug delivery are described herein. An apparatus can include a housing, an energy storage member, a barrel, and a hub. The housing contains the energy storage member. A proximal end portion of the barrel is coupled to a distal end portion of the housing. The barrel is configured to contain medicament and includes at least a portion of a piston and an elastomeric member. The piston is configured to move the elastomeric member within the barrel in response to a force produced by the energy storage member. The hub is coupled to a distal end portion of the barrel. An inner surface of the hub defines a nozzle through which the medicament flows when the elastomeric member moves within the barrel. The nozzle and the energy storage member are collectively configured to produce a fluid jet to access a target location within an eye.Type: GrantFiled: November 1, 2018Date of Patent: March 7, 2023Assignee: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor Andino, Thomas Edward Godfrey, Shelley Eckert Hancock, Samirkumar Patel, Keleigh Jo Mahn, Jesse Yoo, Vladimir Zarnitsyn
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Patent number: 11559428Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: July 12, 2019Date of Patent: January 24, 2023Assignee: Clearside Biomedical, Inc.Inventors: Rafael Victor Andino, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Publication number: 20210260047Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.Type: ApplicationFiled: May 7, 2021Publication date: August 26, 2021Inventors: Vladimir ZARNITSYN, Samirkumar PATEL, Daniel WHITE, Glenn NORONHA, Brian BURKE
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Publication number: 20210236336Abstract: A corneal injection needle is disclosed. The corneal injection needle includes a shaft, a housing, and a stop feature for controlling the depth of the needle penetration. The needle is capable of delivering precise amounts of injectable material to the cornea with low leakage rates to off-target areas and less corneal damage compared to conventional needles.Type: ApplicationFiled: May 9, 2019Publication date: August 5, 2021Inventors: Brian C. Gilger, Vladimir Zarnitsyn, Samirkumar Patel
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Publication number: 20200383965Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.Type: ApplicationFiled: January 8, 2020Publication date: December 10, 2020Inventors: Vladimir ZARNITSYN, Samirkumar PATEL, Daniel WHITE, Glenn NORONHA, Brian BURKE
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Patent number: 10722396Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: October 2, 2019Date of Patent: July 28, 2020Assignee: CLEARSIDE BIOMEDICAL., INC.Inventors: Rafael Victor Andino, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Patent number: 10555833Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: April 6, 2018Date of Patent: February 11, 2020Assignee: Clearside Biomedical, Inc.Inventors: Rafael Victor Andino, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Publication number: 20200030143Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: October 2, 2019Publication date: January 30, 2020Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor ANDINO, Vladimir ZARNITSYN, Jesse YOO, Christopher John BROOKS, Trent John KAHUTE, Justin William ARSENAULT, David Jackson TRETTIN, Andrew Kent BAUER, Stephanie Elaine LEWIS
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Patent number: 10517756Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: April 11, 2019Date of Patent: December 31, 2019Assignee: CLEARSIDE BIOMEDICAL, INCInventors: Rafael Victor Andino, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Publication number: 20190350755Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: July 12, 2019Publication date: November 21, 2019Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor ANDINO, Vladimir ZARNITSYN, Jesse YOO, Christopher John BROOKS, Trent John KAHUTE, Justin William ARSENAULT, David Jackson TRETTIN, Andrew Kent BAUER, Stephanie Elaine LEWIS
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Publication number: 20190307606Abstract: Devices, methods, and kits for ocular drug delivery are described herein. An apparatus can include a housing, an energy storage member, a barrel, and a hub. The housing contains the energy storage member. A proximal end portion of the barrel is coupled to a distal end portion of the housing. The barrel is configured to contain medicament and includes at least a portion of a piston and an elastomeric member. The piston is configured to move the elastomeric member within the barrel in response to a force produced by the energy storage member. The hub is coupled to a distal end portion of the barrel. An inner surface of the hub defines a nozzle through which the medicament flows when the elastomeric member moves within the barrel. The nozzle and the energy storage member are collectively configured to produce a fluid jet to access a target location within an eye.Type: ApplicationFiled: November 1, 2018Publication date: October 10, 2019Inventors: Rafael Victor ANDINO, Thomas Edward GODFREY, Shelley Eckert HANCOCK, Samirkumar PATEL, Keleigh Jo MAHN, Jesse YOO, Vladimir ZARNITSYN
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Publication number: 20190290485Abstract: Devices, methods, and kits for ocular drug delivery are described herein. In some embodiments, a method includes inserting a distal end portion of a puncture member into an eye to define a delivery passageway within the eye. The delivery passageway extends through ha sclera of the eye and a choroid of the eye. The delivery passageway is less than about 1.5 mm. The method further includes conveying a substance into a subretinal space within the eye via the distal end portion of the puncture member.Type: ApplicationFiled: June 13, 2019Publication date: September 26, 2019Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor ANDINO, Thomas Edward GODFREY, Shelley Eckert HANCOCK, Samirkumar PATEL, Keleigh Jo STRUDTHOFF, Jesse YOO, Vladimir ZARNITSYN
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Publication number: 20190240208Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.Type: ApplicationFiled: September 7, 2018Publication date: August 8, 2019Inventors: Vladimir ZARNITSYN, Samirkumar PATEL, Daniel WHITE, Glenn NORONHA, Brian BURKE
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Publication number: 20190231592Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: April 11, 2019Publication date: August 1, 2019Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor ANDINO, Vladimir ZARNITSYN, Jesse YOO, Christopher John BROOKS, Trent John KAHUTE, Justin William ARSENAULT, David Jackson TRETTIN, Andrew Kent BAUER, Stephanie Elaine LEWIS
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Publication number: 20190133933Abstract: The current disclosure relates to formulations and methods for reducing intraocular pressure (IOP) in the eye of a subject in need thereof. The disclosure also relates to formulations and methods for reducing intraocular pressure (IOP) related to glaucoma in a subject. The methods provided include non-surgically administering a non-pharmacologically active injectable formulation to the eye of the subject by using an apparatus that is suitable for delivering the formulations. The methods provided also include placing a solid implant into the eye of the subject to create a controlled space in the suprachoroidal space (SCS) or the supraciliary space of the eye of the subject in need thereof. The present disclosure further comprises facilitating and improving the aqueous outflows in the eye through the trabecular meshwork outflow pathway and/or uveoscleral outflow pathway and thereby decreasing the intraocular pressure.Type: ApplicationFiled: May 1, 2017Publication date: May 9, 2019Inventors: Richard BECKMAN, Jesse YOO, Rafael Victor ANDINO, Glenn NORONHA, Samirkumar PATEL, Donna TARABORELLI, Vladimir ZARNITSYN
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Patent number: 10188550Abstract: A cartridge, including a first member that defines an inner volume and a second member disposed therein, is disposed in a housing. A first reservoir is disposed in the inner volume in a position distal to the second member. The first member is partially disposed in a second reservoir, defined by the housing. The second member is configured to be moved from a first position, in which the first reservoir contains a drug and the second reservoir is fluidically isolated from the inner volume, toward a second position, in which the first reservoir and the second reservoir are in fluid communication with the inner volume, such that the second reservoir receives a volume of the drug from the first reservoir. The first member and the second member are collectively moved relative to the second reservoir to expel the volume of the drug from the second reservoir.Type: GrantFiled: May 30, 2014Date of Patent: January 29, 2019Assignee: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor Andino, Samirkumar R. Patel, Vladimir Zarnitsyn, Christopher John Brooks
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Publication number: 20180333297Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: April 6, 2018Publication date: November 22, 2018Applicant: Clearside Biomedical, Inc.Inventors: Rafael Victor ANDINO, Vladimir ZARNITSYN, Jesse YOO, Christopher John BROOKS, Trent John KAHUTE, Justin William ARSENAULT, David Jackson TRETTIN, Andrew Kent BAUER, Stephanie Elaine LEWIS
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Publication number: 20180325884Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.Type: ApplicationFiled: July 20, 2018Publication date: November 15, 2018Inventors: Vladimir ZARNITSYN, Samirkumar PATEL, Daniel WHITE, Glenn NORONHA, Brian BURKE
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Patent number: 9956114Abstract: An apparatus includes a microneedle that defines a lumen therethrough. The microneedle has a proximal end portion a distal end portion and a hub portion between the proximal end portion and the distal end portion. The proximal end portion is configured to be coupled to a medicament container, such as, for example a syringe. The portion of the lumen within the proximal end portion has a first diameter. The distal end portion is configured to pierce a target tissue. The portion of the lumen within the distal end portion has a second diameter smaller than the first diameter. The hub portion includes a surface configured to contact the target tissue when the distal end portion is disposed with the target tissue.Type: GrantFiled: December 19, 2016Date of Patent: May 1, 2018Assignee: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor Andino, Christopher John Brooks, Vladimir Zarnitsyn, Harrison J. White