Patents by Inventor Vladislav M. SANDLER

Vladislav M. SANDLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Post-natal hematopoeitic endothelial cells and their isolation and use
    Patent number: 10570373
    Abstract: Provided herein are methods of isolation and identification of post-natal hemogenic endothelial cells. Further provided are substantially purified populations of post-natal hemogenic endothelial cells, compositions of post-natal hemogenic endothelial cells, and methods to utilize hemogenic endothelial cells to regenerate the hematopoietic system in a subject.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: February 25, 2020
    Assignee: Cornell University
    Inventor: Vladislav M. Sandler
  • Reprogramming of human endothelium into hematopoietic multi-lineage progenitors by defined factors
    Patent number: 10113149
    Abstract: The invention is directed to generation of hematopoietic multi-lineage progenitors (HMLPs) from endothelial cells (ECs) by effecting forced expression of certain transcription factors in the ECs and culturing the ECs in serum free media in the presence of endothelial feeder cells. The HMLPs generated in accordance with this invention can produce erythroid, lymphoid, myeloid, and megakaryocyte cells. These generated HMLPs can be used in therapeutic treatment of disorders including hematopoietic conditions.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: October 30, 2018
    Assignee: CORNELL UNIVERSITY
    Inventors: Vladislav M. Sandler, Shahin Raffi
  • POST-NATAL HEMATOPOEITIC ENDOTHELIAL CELLS AND THEIR ISOLATION AND USE
    Publication number: 20160251622
    Abstract: Provided herein are methods of isolation and identification of post-natal hemogenic endothelial cells. Further provided are substantially purified populations of post-natal hemogenic endothelial cells, compositions of post-natal hemogenic endothelial cells, and methods to utilize hemogenic endothelial cells to regenerate the hematopoietic system in a subject.
    Type: Application
    Filed: November 13, 2014
    Publication date: September 1, 2016
    Applicant: CORNELL UNIVERSITY
    Inventor: Vladislav M. SANDLER
  • REPROGRAMMING OF HUMAN ENDOTHELIUM INTO HEMATOPOIETIC MULTI-LINEAGE PROGENITORS BY DEFINED FACTORS
    Publication number: 20150361398
    Abstract: The invention is directed to generation of hematopoietic multi-lineage progenitors (HMLPs) from endothelial cells (ECs) by effecting forced expression of certain transcription factors in the ECs and culturing the ECs in serum free media in the presence of endothelial feeder cells. The HMLPs generated in accordance with this invention can produce erythroid, lymphoid, myeloid, and megakaryocyte cells. These generated HMLPs can be used in therapeutic treatment of disorders including hematopoietic conditions.
    Type: Application
    Filed: January 15, 2014
    Publication date: December 17, 2015
    Applicant: CORMELL UNIVERSITY
    Inventors: Vladislav M. SANDLER, Shahin RAFFI