Patents by Inventor Vojtech Pujman

Vojtech Pujman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4661297
    Abstract: Basic ethers of 7-oxo-7H-benzo(c) fluorene have been shown to evidence a pronounced antineoplastic and immunosuppressive effect in mammals suffering from leukemia. The technique for preparing the described ethers and the addition salts thereof with pharmaceutically acceptable organic and inorganic acids involves the aminoalkylation of 5-hydroxy-7-oxo-7H-benzo(c) fluorene and its corresponding nuclear substituted derivatives on the hydroxylic oxygen atom.
    Type: Grant
    Filed: September 14, 1982
    Date of Patent: April 28, 1987
    Assignee: SPOFA, spojene podniky pro zdravotnickou vyrobu
    Inventors: Jiri Krepelka, Iva Vancurova, Karel Rezabek, Milan Melka, Vojtech Pujman, Stanislava Pokorna, Ruzena Reichlova, Slavjanka Cernochova
  • Patent number: 4237270
    Abstract: 5-Carboxyalkyl-2-iminobarbituric and 5-carboxyalkyl-2-thioxobarbituric acids and derivatives thereof are prepared either by condensation of a triester of a tricarboxylic acid with a thio or imino diamide to yield an ester which is saponified, the desired compound being obtained by liberation with a mineral acid from an ammoniacal medium containing the saponified ester. Alternatively, free tricarboxylic acids may be substituted for the triesters. The compounds described herein have evidenced a therapeutic effect in animals having transplanted tumors, and have inhibited tumor growth and lengthened the life of animals and humans.
    Type: Grant
    Filed: April 20, 1978
    Date of Patent: December 2, 1980
    Assignee: SPOFA, United Pharmaceutical Works
    Inventors: Miroslav Semonsky, Rudolf Kotva, Antonin Cerny, Jiri Krepelka, Vojtech Pujman, Oskar Andrysek, Hana Vesela, deceased